Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marc Valentine"'
Autor:
Kaitly J. Woodard, Phillip A. Doerfler, Kalin D. Mayberry, Akshay Sharma, Rachel Levine, Jonathan Yen, Virginia Valentine, Lance E. Palmer, Marc Valentine, Mitchell J. Weiss
Publikováno v:
Disease Models & Mechanisms. 15
We characterized the human β-like globin transgenes in two mouse models of sickle cell disease (SCD) and tested a genome-editing strategy to induce red blood cell fetal hemoglobin (HbF; α2γ2). Berkeley SCD mice contain four to 22 randomly arranged
Autor:
Heather L. Mulder, Peter Vogel, Steven Henikoff, Marcin Kamiński, Richard K. Wilson, Jinghui Zhang, Anang A. Shelat, James R. Downing, Marc Valentine, Yanling Liu, Xin Zhou, Yiping Fan, Armita Bahrami, Arlene Naranjo, Collin Van Ryn, Rani E. George, Sara M. Federico, Beisi Xu, Jongrye Jeon, Seungjae Lee, Xiang Chen, Elizabeth Stewart, John Easton, Donald Yergeau, Shondra M. Pruett-Miller, Jay F. Sarthy, Michael P. Meers, Maged Zeineldin, Michael A. Dyer, Lyra Griffiths, Michael R. Clay, Jackie L. Norrie, Elaine R. Mardis, Rosa Nguyen, Alberto S. Pappo, Michael D. Hogarty, Jianrong Wu
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Aggressive cancers often have activating mutations in growth-controlling oncogenes and inactivating mutations in tumor-suppressor genes. In neuroblastoma, amplification of the MYCN oncogene and inactivation of the ATRX tumor-suppressor gene correlate
Autor:
Daniel J. Hiler, Issam Aldiri, Marc Valentine, Abbas Shirinifard, Michael A. Dyer, Suresh Thiagarajan, Xin Zhou, Dianna A. Johnson, Xiang Chen, Jiakun Zhang, Lu Wang, Lyra Griffiths, Andras Sablauer, Marie E. Barabas, Beisi Xu, Sharon Frase
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2601-2614 (2018)
Cell reports
Cell reports
SUMMARY Diverse cell types can be reprogrammed into pluripotent stem cells by ectopic expression of Oct4 (Pou5f1), Klf4, Sox3, and Myc. Many of these induced pluripotent stem cells (iPSCs) retain memory, in terms of DNA methylation and histone modifi
Autor:
Xiang Chen, John Easton, Issam Al Diri, Daniel Putnam, Michael A. Dyer, Lyra Griffiths, Beisi Xu, Marc Valentine, Dianna A. Johnson, Shondra Miller, Marybeth S. Lupo, Sharon Frase, Jackie L. Norrie, Jiakun Zhang, Ying Shao, Xin Zhou, Victoria Honnell, Valerie Stewart
Publikováno v:
Neuron
More than 8,000 genes are turned on or off as progenitor cells produce the 7 classes of retinal cell types during development. Thousands of enhancers are also active in the developing retinae, many having features of cell- and developmental stage-spe
Autor:
Philip C. Wong, Fen-Biao Gao, Nam Chul Kim, Rodrigo Lopez-Gonzalez, Brian D. Freibaum, Bruce L. Miller, Leonard Petrucelli, Nisha M. Badders, Hong Joo Kim, J. Paul Taylor, Sandra Almeida, Marc Valentine, Kyung-Ha Lee, Yubing Lu
Publikováno v:
Nature, vol 525, iss 7567
The GGGGCC (G4C2) repeat expansion in a noncoding region of C9orf72 is the most common cause of sporadic and familial forms of amyotrophic lateral sclerosis and frontotemporal dementia. The basis for pathogenesis is unknown. To elucidate the conseque
Autor:
Vaibhav Sahai, Jerold E. Rehg, Lesa Begley, David Escobar, Marc Valentine, Peter J. McKinnon, Jianming Ye, Ming Yi Chiang, Beatriz Sosa-Pineda, Leena Paul, Yiannis Drosos, Virginia Valentine, Kathryn Roys
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Germline mutations in ATM (encoding the DNA-damage signaling kinase, ataxia-telangiectasia-mutated) increase Familial Pancreatic Cancer (FPC) susceptibility, and ATM somatic mutations have been identified in resected human pancreatic tumors. Here we
Autor:
Katherine A. High, Scott Jackson, Junfang Zhou, Cecilia Rosales, Simon N. Waddington, Deepak Raj, Susan Sleep, Amit C. Nathwani, Federico Mingozzi, Yunyu Spence, Arthur W. Nienhuis, Sushmita Nawathe, James A. Allay, John Coleman, Andrew M. Davidoff, Robert E. Donahue, John T. Gray, Jenny McIntosh, Ghasem Rastegarlari, Marc Valentine, Roderick T. Bronson, M. Beth McCarville, Devhrut Nathwani, Catherine Y.C. Ng
Publikováno v:
Molecular Therapy. 19:876-885
Adeno-associated virus vectors (AAV) show promise for liver-targeted gene therapy. In this study, we examined the long-term consequences of a single intravenous administration of a self-complementary AAV vector (scAAV2/ 8-LP1-hFIXco) encoding a codon
Autor:
Marc Valentine, Paul E. Mead, Andrea P. Subhawong, Emin Kuliyev, Taylor D. Archer, Joanne R. Doherty, Donald Yergeau, Haiqing Zhu, Michelle R. Johnson Hamlet, Clair M. Kelley
Publikováno v:
Developmental Dynamics. 238:1727-1743
Transposon-based integration systems have been widely used for genetic manipulation of invertebrate and plant model systems. In the past decade, these powerful tools have begun to be used in vertebrates for transgenesis, insertional mutagenesis, and
Autor:
Christopher Calabrese, Jerold E. Rehg, Marc Valentine, Tamar Uziel, Martine F. Roussel, Charles J. Sherr, Frederique Zindy, Richard J. Gilbertson, Olivier Ayrault
Publikováno v:
Cancer Research. 67:2676-2684
Mice lacking p53 and one or two alleles of the cyclin D–dependent kinase inhibitor p18Ink4c are prone to medulloblastoma development. The tumor frequency is increased by exposing postnatal animals to ionizing radiation at a time when their cerebell
Autor:
Nicholas M. Kredich, James De La Rosa, Arthur M. Geller, Marc Valentine, Monika M. Hryniewicz, Malak Kotb, H. Leighton LeGros, J Ostrowski
Publikováno v:
The Journal of biological chemistry. 270(37)
Human lymphocyte methionine adenosyltransferase (HuLy MAT) consists of heterologous subunits alpha and beta. The cDNA sequence of the alpha subunit of HuLy MAT from Jurkat leukemic T cells was identical to that of the human kidney alpha subunit and h