Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Kroemer G"'
Autor:
Pietrocola F., Castoldi F., Markaki M., Lachkar S., Chen G., Enot D. P., Durand S., Bossut N., Tong M., Malik S. A., Loos F., Dupont N., Marino G., Abdelkader N., Madeo F., Maiuri M. C., Kroemer R., Codogno P., Sadoshima J., Tavernarakis N., Kroemer G.
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2395-2407 (2018)
Summary: The age-associated deterioration in cellular and organismal functions associates with dysregulation of nutrient-sensing pathways and disabled autophagy. The reactivation of autophagic flux may prevent or ameliorate age-related metabolic dysf
Autor:
Villella, V. R., Esposito, S., Ferrari, E., Monzani, R., Tosco, A., Rossin, F., Castaldo, A., Silano, M., Marseglia, G. L., Romani, L., Barlev, N. A., Piacentini, M., Raia, V., Kroemer, G., Maiuri, L.
Publikováno v:
Cell Death & Disease
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2019, 10 (4), pp.258. ⟨10.1038/s41419-019-1500-x⟩
Cell Death and Disease, Vol 10, Iss 4, Pp 1-11 (2019)
Cell Death and Disease
Cell Death and Disease, Nature Publishing Group, 2019, 10 (4), pp.258. ⟨10.1038/s41419-019-1500-x⟩
Cell Death and Disease, Vol 10, Iss 4, Pp 1-11 (2019)
International audience; Under physiological conditions, a finely tuned system of cellular adaptation allows the intestinal mucosa to maintain the gut barrier function while avoiding excessive immune responses to non-self-antigens from dietary origin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::18f9020bda3ee58d2bc5986e9cf47f56
http://hdl.handle.net/2108/233021
http://hdl.handle.net/2108/233021
Autor:
Sica V., Bravo-San Pedro J. M., Izzo V., Pol J., Pierredon S., Enot D., Durand S., Bossut N., Chery A., Souquere S., Pierron G., Vartholomaiou E., Zamzami N., Soussi T., Sauvat A., Mondragon L., Kepp O., Galluzzi L., Martinou J. -C., Hess-Stumpp H., Ziegelbauer K., Kroemer G., Maiuri M. C.
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2019, 27 (3), pp.820-834.e9. ⟨10.1016/j.celrep.2019.03.058⟩
Cell Reports, Vol 27, Iss 3, Pp 820-834.e9 (2019)
Cell Reports, 2019, 27 (3), pp.820-834.e9. ⟨10.1016/j.celrep.2019.03.058⟩
Cell Reports, Elsevier Inc, 2019, 27 (3), pp.820-834.e9. ⟨10.1016/j.celrep.2019.03.058⟩
Cell Reports, Vol 27, Iss 3, Pp 820-834.e9 (2019)
Cell Reports, 2019, 27 (3), pp.820-834.e9. ⟨10.1016/j.celrep.2019.03.058⟩
Summary: Inhibition of oxidative phosphorylation (OXPHOS) by 1-cyclopropyl-4-(4-[(5-methyl-3-(3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl]pyridin-2-yl)piperazine (BAY87-2243, abbreviated as B87), a complex I inhibitor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9237f157179cf62166902e847f70abc7
https://hal.sorbonne-universite.fr/hal-02317988
https://hal.sorbonne-universite.fr/hal-02317988
Autor:
Mollereau, B., Rzechorzek, N. M., Roussel, B. D., Sedru, M., Brink, D., Bailly-Maitre, B., Palladino, F., Medinas, D. B., Domingos, P. M., Hunot, S., Chandran, S., Birman, S., Baron, T., Vivien, D., Duarte, C. B., Ryoo, H. D., Steller, H., Urano, F., Chevet, E., Kroemer, G., Ciechanover, A., Calabrese, E. J., Kaufman, R. J., Hetz, C
Publikováno v:
Brain Research
Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. 〈10.1016/j.brainres.2016.02.033〉
Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. ⟨10.1016/j.brainres.2016.02.033⟩
Mollereau, B, Rzechorzek, N M, Roussel, BD, Sedru, M, Van denBrink, D, Bailly-Maitre, B, Palladino, F, Medinas, DB, Domingos, PM, Hunot, S, Chandran, S, Birman, S, Baron, T, Vivien, D, Duarte, CB, Ryoo, HD, Steller, H, Urano, F, Chevet, E, Kroemer, G, Ciechanover, A, Calabrese, EJ, Kaufman, RJ & Hetz, C 2016, ' Adaptive preconditioning in neurological diseases- therapeutic insights from proteostatic perturbations ', Brain Research . https://doi.org/10.1016/j.brainres.2016.02.033
Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. 〈10.1016/j.brainres.2016.02.033〉
Brain Research, Elsevier, 2016, 1648 (B), pp.603-616. ⟨10.1016/j.brainres.2016.02.033⟩
Mollereau, B, Rzechorzek, N M, Roussel, BD, Sedru, M, Van denBrink, D, Bailly-Maitre, B, Palladino, F, Medinas, DB, Domingos, PM, Hunot, S, Chandran, S, Birman, S, Baron, T, Vivien, D, Duarte, CB, Ryoo, HD, Steller, H, Urano, F, Chevet, E, Kroemer, G, Ciechanover, A, Calabrese, EJ, Kaufman, RJ & Hetz, C 2016, ' Adaptive preconditioning in neurological diseases- therapeutic insights from proteostatic perturbations ', Brain Research . https://doi.org/10.1016/j.brainres.2016.02.033
In neurological disorders, both acute and chronic neural stress can disrupt cellular proteostasis, resulting in the generation of pathological protein. However in most cases, neurons adapt to these proteostatic perturbations by activating a range of
Autor:
Rockenfeller, P, Koska, M, Pietrocola, F, Minois, N, Knittelfelder, O, Sica, V, Franz, J, Carmona-Gutierrez, D, Kroemer, G, Madeo, F
Publikováno v:
Cell Death and Differentiation
This work was supported by the Austrian Science Fund FWF (grants LIPOTOX, I1000-B20, P23490-B12, and P24381-B20) to FM. The authors acknowledge support from NAWI Graz. OK is a member of the PhD program ‘Molecular Enzymology’, funded by the FWF (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4aed14a0fa347432480c818d37ea217d
https://hdl.handle.net/10023/6250
https://hdl.handle.net/10023/6250
Autor:
Niso Santano M., Criollo A., Malik S. A., Michaud M., Morselli E., Mariño G., Lachkar S., Galluzzi L., Kroemer G., MAIURI, MARIA CHIARA
General (macro)autophagy and the activation of NFκB constitute prominent responses to a large array of intracellular and extracellular stress conditions. The depletion of any of the three subunits of the inhibitor of NFκB (IκB) kinase (IKKα, IKK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a51f8ecefddb8517101254199234ace
http://hdl.handle.net/11588/517380
http://hdl.handle.net/11588/517380
Autor:
Ja, Gonzalo, González-García A, ELENA BAIXERAS, Zamzami N, Tarazona R, Rappuoli R, Martínez C, Kroemer G, Terezone R
Publikováno v:
Europe PubMed Central
Intravenous injection of a bacterial superantigen such as Staphylococcus aureus enterotoxin B (SEB) causes transient activation and expansion of SEB-reactive V beta 8+ T cells, as well as specific down-regulation of the immune response, through parti
Autor:
Sabbah, B, Druillennec, S., Morellet, N., Bouaziz, B, Kroemer, G., Roques, B.P., Sabbah, Emmanuelle, Bouaziz, S.
Publikováno v:
Chemical Biology Drug Design
Chemical Biology Drug Design, 2006, 67 (2), pp.145-154. ⟨10.1111/j.1747-0285.2006.00340.x⟩
Chemical Biology Drug Design, 2006, 67 (2), pp.145-154. ⟨10.1111/j.1747-0285.2006.00340.x⟩
International audience; The HIV-1 protein Vpr circulates in the serum of seropositive individuals and in the cerebrospinal fluid of AIDS patients with neurological disorders. Vpr triggers apoptosis of numerous cell types after extracellular addition,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2825fecc2dc2bd76e2df5c80fae4ead9
https://hal.archives-ouvertes.fr/hal-02122532
https://hal.archives-ouvertes.fr/hal-02122532
Autor:
Rippo, M. R., Malisan, F., Ravagnan, L., Tomassini, B., Condò, I., Costantini, P., Santos A. Susin, Rufini, A., Todaro, M., Kroemer, G., Testi, R.
Publikováno v:
ResearcherID
Scopus-Elsevier
Scopus-Elsevier
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::21df03012cabc9a4fccff84162fdcf41
http://hdl.handle.net/11577/1341541
http://hdl.handle.net/11577/1341541
Autor:
Hirsch, T., Dallaporta, B., Zamzami, N., Santos A. Susin, Ravagnan, L., Marzo, I., Brenner, C., Kroemer, G.
Publikováno v:
Scopus-Elsevier
Proteasomes and mitochondrial membrane changes are involved in thymocyte apoptosis. The hierarchical relationship between protease activation and mitochondrial alterations has been elusive. Here we show that inhibition of proteasomes by two specific