Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Katrina Sweeney"'
Autor:
Heike Müller, Virginie Adam, Na Ra Kang, Nicholas R. Lemoine, Gunnel Halldén, Maria Ekblad, Katrina Sweeney, Kristina Hammarén Busch, Camilla Tørnqvist Johnsen
Publikováno v:
Human Gene Therapy. 23:1003-1015
AdΔΔ is an oncolytic adenoviral mutant that has been engineered to selectively target tumors with deregulated cell cycle and apoptosis pathways. AdΔΔ potentiates apoptotic cell death induced by drugs, including mitoxantrone and docetaxel, which a
Autor:
Sarah P. Blagden, Sadaf Ghaem-Maghami, Andrea J. Berman, Normala Abd-Latip, Roni M. Lahr, Jennifer H. Steel, Hiba A. Al-Ashtal, Justin Weir, Eric O. Aboagye, Manuela Mura, Mona El-Bahrawy, Haonan Lu, T.G. Hopkins, Katrina Sweeney
Publikováno v:
Nucleic Acids Research
RNA-binding proteins (RBPs) are increasingly identified as post-transcriptional drivers of cancer progression. The RBP LARP1 is an mRNA stability regulator, and elevated expression of the protein in hepatocellular and lung cancers is correlated with
Autor:
Philip A. Gregory, Margaret M. Centenera, Lisa M. Butler, Brett G. Hollier, Rajdeep Das, Nataly Stylianou, Wayne D. Tilley, Scott L. Townley, Adrienne R. Hanson, Amina Zoubeidi, Gregory J. Goodall, Carolina Soekmadji, Katrina Sweeney, Colleen C. Nelson, Isabel Coutinho, Lidija Jovanovic, Luke A. Selth
Publikováno v:
Europe PubMed Central
MicroRNA-375 (miR-375) is frequently elevated in prostate tumors and cell-free fractions of patient blood, but its role in genesis and progression of prostate cancer is poorly understood. In this study, we demonstrated that miR-375 is inversely corre
Autor:
Gunnel Halldén, Celina Costas, Eva Yanover, Virginie Adam, Nicholas R. Lemoine, Daniel Öberg, Katrina Sweeney
Publikováno v:
Clinical Cancer Research. 16:541-553
Purpose: Replication-selective oncolytic adenoviruses are a promising class of tumor-targeting agents with proven safety in hundreds of patients. However, clinical responses have been limited and viral mutants with higher potency are needed. Here, we
Autor:
Daniel Öberg, Enrique Miranda, Nicholas R. Lemoine, Gunnel Halldén, Katrina Sweeney, Derek Davies, Stephan Leitner
Publikováno v:
Clinical Cancer Research. 15:1730-1740
Purpose: Pancreatic adenocarcinoma is a rapidly progressive malignancy that is highly resistant to current chemotherapeutic modalities and almost uniformly fatal. We show that a novel targeting strategy combining oncolytic adenoviral mutants with the
Autor:
Hill R, Katrina Sweeney, David H. Kirn, Cheong Sc, Gunnel Halldén, Yaohe Wang, Jianghui Meng, Nicholas R. Lemoine
The majority of clinical trials evaluating replication-selective oncolytic adenoviruses utilized mutants with immunomodulatory E3B genes deleted, likely contributing to the attenuated efficacy. We investigated whether an intact immune response could
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db0c9ef385491719a81e119d176ac528
https://europepmc.org/articles/PMC2268748/
https://europepmc.org/articles/PMC2268748/