Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Jorge Cruz-Reyes"'
Autor:
Jana Gomez, Jair L. Siqueira-Neto, Drake M. Mellott, Jorge Cruz-Reyes, Emily Desormeaux, Claudia Calvet Alvarez, Jean A. Bernatchez, Thomas D. Meek, Linfeng Li, Xiang Zhai, Elizabeth Alvarez Hernandez, Balachandra Chenna, James H. McKerrow
Publikováno v:
J Med Chem
Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaff
Autor:
Jorge Cruz-Reyes, Andrew Hillhouse, Daniel Camilo Osorio Hurtado, Alasdair Ivens, Xiuren Zhang, Pawan K. Doharey, Joshua Meehan, Zachary T Goodall, Achim Schnaufer, Vikas Kumar, James J. Cai
Publikováno v:
Kumar, V, Ivens, A, Goodall, Z, Meehan, J, Doharey, P K, Hillhouse, A, Hurtado, D O, Cai, J J, Zhang, X, Schnaufer, A & Cruz-Reyes, J 2020, ' Site-specific and mRNA-specific control of accurate mRNA editing by a helicase complex in trypanosomes ', RNA, vol. 26, no. 10, rna.076513.120 . https://doi.org/10.1261/rna.076513.120
RNA
RNA
Trypanosome U-insertion/deletion RNA editing in mitochondrial mRNAs involves guide RNAs (gRNAs) and the auxiliary RNA editing substrate binding complex (RESC) and RNA editing helicase 2 complex (REH2C). RESC and REH2C stably copurify with editing mRN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7544f1407045fc8df53ea00d87dc63e7
https://www.pure.ed.ac.uk/ws/files/164850025/RNA_2020_Kumar_rna.076513.120.pdf
https://www.pure.ed.ac.uk/ws/files/164850025/RNA_2020_Kumar_rna.076513.120.pdf
Autor:
Suzanne M. McDermott, Z. Hong Zhou, H. Ulrich Göringer, Alena Zíková, Kenneth Stuart, Igor Cestari, Reza Salavati, Stephen L. Hajduk, Julius Lukeš, Ruslan Aphasizhev, Dmitri A. Maslov, Jason Carnes, Achim Schnaufer, Inna Aphasizheva, Larry Simpson, Torsten Ochsenreiter, Jorge Cruz-Reyes, Laurie K. Read, André Schneider, Susan Madison-Antenucci, Vyacheslav Yurchenko, Liye Zhang, Juan D. Alfonzo, Sara L. Zimmer
Publikováno v:
Aphasizheva, I, Alfonzo, J, Carnes, J, Cestari, I, Cruz-Reyes, J, Göringer, H U, Hajduk, S, Lukeš, J, Madison-Antenucci, S, Maslov, D A, McDermott, S M, Ochsenreiter, T, Read, L K, Salavati, R, Schnaufer, A, Schneider, A, Simpson, L, Stuart, K, Yurchenko, V, Zhou, Z H, Zíková, A, Zhang, L, Zimmer, S & Aphasizhev, R 2020, ' Lexis and grammar of mitochondrial RNA processing in Trypanosomes ', Trends in Parasitology, vol. 36, no. 4, pp. 337-355 . https://doi.org/10.1016/j.pt.2020.01.006
Trends in parasitology, vol 36, iss 4
Trends in parasitology, vol 36, iss 4
Trypanosoma brucei spp. cause African human and animal trypanosomiasis, a burden on health and economy in Africa. These hemoflagellates are distinguished by a kinetoplast nucleoid containing mitochondrial DNAs of two kinds: maxicircles encoding ribos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8171b9f7520b2af84d845636eb4343d1
https://hdl.handle.net/20.500.11820/def562e4-fc49-427d-84a3-da811b3f009b
https://hdl.handle.net/20.500.11820/def562e4-fc49-427d-84a3-da811b3f009b
Publikováno v:
RNA. 12:1292-1303
RBP16 is an abundant RNA binding protein from Trypanosoma brucei mitochondria that affects both RNA editing and stability. We report here experiments aimed at elucidating the mechanism of RBP16 function in RNA editing. In in vitro RNA editing assays,
Autor:
Alevtina G. Zhelonkina, Julie A. Law, Jorge Cruz-Reyes, Barbara Sollner-Webb, Catherine E. Huang, Vadim S. Alatortsev, Sean F. O'Hearn
Publikováno v:
RNA. 12:476-487
Trypanosome RNA editing is massive post-transcriptional U-insertion and U-deletion, which generates mature mRNA coding regions through cycles of endonuclease, terminal U transferase (TUTase) or 3′-U-exo, and ligase action. Both types of editing are
Publikováno v:
Molecular and Cellular Biology. 22:4652-4660
Trypanosome RNA editing is a unique U insertion and U deletion process that involves cycles of pre-mRNA cleavage, terminal U addition or U removal, and religation. This editing can occur at massive levels and is directed by base pairing of trans-acti
Publikováno v:
Molecular and Cellular Biology. 21:884-892
Trypanosome RNA editing is a massive processing of mRNA by U deletion and U insertion, directed by trans-acting guide RNAs (gRNAs). A U deletion cycle and a U insertion cycle have been reproduced in vitro using synthetic ATPase (A6) pre-mRNA and gRNA
Publikováno v:
The EMBO Journal. 16:4069-4081
Kinetoplastid mitochondrial RNA editing, the insertion and deletion of U residues, is catalyzed by sequential cleavage, U addition or removal, and ligation reactions and is directed by complementary guide RNAs. We have purified a approximately 20S en
Autor:
Barbara Sollner-Webb, Jorge Cruz-Reyes
Publikováno v:
Proceedings of the National Academy of Sciences. 93:8901-8906
We have studied the mechanism of accurate in vitro RNA editing of Trypanosoma brucei ATPase 6 mRNA, using four mRNA-guide RNA (gRNA) pairs that specify deletion of 2, 3, or 4 U residues at editing site 1 and mitochondrial extract. This extract not on
Publikováno v:
Parasitology. 104:239-246
SUMMARYRecombinant ribosomal DNA sequences were amplified by PCR and used as probes to perform a fingerprint analysis of total DNA from differentEntamoeba histolyticaisolates. RFLPs obtained with one of the probes, R-1, support previous proposals tha