Zobrazeno 1 - 10
of 294
pro vyhledávání: '"James A. Brown"'
Autor:
Kyle G, Mathews, James C, Brown, Lola C, Hudson, Emily H, Griffith, Alan J, Bocage, Jonathan A, Hash
Publikováno v:
American Journal of Veterinary Research. 83
OBJECTIVE To determine whether muscle-sparing laryngoplasty results in fewer changes in swallowing function compared to standard surgical treatment for laryngeal paralysis. ANIMALS 12 clinically normal sexually intact male Beagles. PROCEDURES Group A
Publikováno v:
Journal of veterinary dentistry. 39(4)
Hypercementosis is infrequently reported to affect the cheek teeth of horses and presents as mineral deposits either attached (peripheral) or solitary ovoid (nodular) structures in the tooth bearing region. There is overlap between radiological and h
Autor:
Hirohiko Tani, Noriomi Matsumura, Asuka Okunomiya, Yukiyasu Sato, Shiro Takamatsu, Eiji Kondoh, Miki Sugimoto, Akihito Horie, Junzo Hamanishi, James B. Brown, Masaki Mandai
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports
The in vitro growth (IVG) of human follicles is a potential fertility option for women for whom cryopreserved ovarian tissues cannot be transplanted due to the risk of cancer cell reintroduction; however, there is currently no established method. Fur
Autor:
Richard, Aarnio, Obada M, Alzghool, Saara, Wahlroos, James, O'Brien-Brown, Michael, Kassiou, Olof, Solin, Juha O, Rinne, Sarita, Forsback, Merja, Haaparanta-Solin
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 219
Radiometabolites of PET tracers interfere with imaging and need to be taken into account when modeling PET data. Various tracer and radiometabolite characteristics affect the uptake rate into tissue. In this study, we investigated two such factors, l
Autor:
Jian-Hua Mao, Siti Nur Sarah Morris, Susan E. Celniker, James B. Brown, William W. Fisher, Kenneth H. Wan, Richard Weiszmann, Mark R. Viant, Benjamin W. Booth, Charles Yu, Soo Park, Ann S. Hammonds, Jennifer A. Kirwan, Sasha A. Langley, Antoine M. Snijders, Ralf J. M. Weber
Publikováno v:
Communications biology, vol 4, iss 1
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
The gut microbiome produces vitamins, nutrients, and neurotransmitters, and helps to modulate the host immune system—and also plays a major role in the metabolism of many exogenous compounds, including drugs and chemical toxicants. However, the ext
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1ffdcd0acbb5a2b1dcf15bed1102fc
https://escholarship.org/uc/item/15g832nr
https://escholarship.org/uc/item/15g832nr
Autor:
Lina Gunnarsson, Bruno Campos, Paul L. Carmichael, Andrew White, John K. Colbourne, Geoff Hodges, Matthew P. Dent, Cecilie Rendal, Imran Shah, Carl Westmoreland, Paul Jennings, Claudia Rivetti, Steve Gutsell, Sharon J. Scott, Aude Kienzler, Ian Sorrel, Emma Butler, Luigi Margiotta-Casaluci, Fiona Sewell, Joshua A. Harrill, Richard S. Judson, Iris Muller, Stewart F. Owen, Timothy E. H. Allen, James B. Brown, Francesco Falciani, Mark R. Viant, Paul J. Russell
Publikováno v:
Toxicology in Vitro, 62:104692, 1-9. Elsevier Limited
Rivetti, C, Allen, T E H, Brown, J B, Butler, E, Carmichael, P L, Colbourne, J K, Dent, M, Falciani, F, Gunnarsson, L, Gutsell, S, Harrill, J A, Hodges, G, Jennings, P, Judson, R, Kienzler, A, Margiotta-Casaluci, L, Muller, I, Owen, S F, Rendal, C, Russell, P J, Scott, S, Sewell, F, Shah, I, Sorrel, I, Viant, M R, Westmoreland, C, White, A & Campos, B 2020, ' Vision of a near future: Bridging the human health–environment divide : Toward an integrated strategy to understand mechanisms across species for chemical safety assessment ', Toxicology in Vitro, vol. 62, 104692, pp. 1-9 . https://doi.org/10.1016/j.tiv.2019.104692
Rivetti, C, Allen, T E H, Brown, J B, Butler, E, Carmichael, P L, Colbourne, J K, Dent, M, Falciani, F, Gunnarsson, L, Gutsell, S, Harrill, J A, Hodges, G, Jennings, P, Judson, R, Kienzler, A, Margiotta-Casaluci, L, Muller, I, Owen, S F, Rendal, C, Russell, P J, Scott, S, Sewell, F, Shah, I, Sorrel, I, Viant, M R, Westmoreland, C, White, A & Campos, B 2020, ' Vision of a near future: Bridging the human health–environment divide : Toward an integrated strategy to understand mechanisms across species for chemical safety assessment ', Toxicology in Vitro, vol. 62, 104692, pp. 1-9 . https://doi.org/10.1016/j.tiv.2019.104692
There is a growing recognition that application of mechanistic approaches to understand cross-species shared molecular targets and pathway conservation in the context of hazard characterization, provide significant opportunities in risk assessment (R
Autor:
James R. Brown, Andrea Nuzzo
Publikováno v:
Chemical Research in Toxicology. 33:119-124
Here we review recent studies that illustrate three areas where the microbiome directly impacts drug development: (1) microbial effects on drug safety and efficacy, (2) the effects of drugs on causing collateral restructuring of microbiome communitie
Autor:
Benoit Pugin, Weronika Barcik, Peter Schmid-Grendelmeier, David L. Mayhew, Liam O'Mahony, Marek Jutel, Noelia Rodriguez-Perez, Stephanie Van Horn, Pawel Gajdanowicz, Remo Frei, Katrine Graversen, Noriane A. Sievi, Milena Sokolowska, Sylwia Smolinska, Edith M. Hessel, Ken A. Saunders, Can Altunbulakli, Magdalena Kurnik-Lucka, Michal Pirozynski, David Michalovich, Sorif Uddin, Cezmi A. Akdis, Andrzej Eljaszewicz, Katrine Lindholm Bøgh, Karen D. Simpson, James R. Brown, Malcolm Kohler, Ruth Ferstl
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Michalovich, D, Rodriguez-Perez, N, Smolinska, S, Pirozynski, M, Mayhew, D, Uddin, S, Van Horn, S, Sokolowska, M, Altunbulakli, C, Eljaszewicz, A, Pugin, B, Barcik, W, Kurnik-Lucka, M, Saunders, K A, Simpson, K D, Schmid-Grendelmeier, P, Ferstl, R, Frei, R, Sievi, N, Kohler, M, Gajdanowicz, P, Graversen, K B, Bøgh, K L, Jutel, M, Brown, J R, Akdis, C A, Hessel, E M & O'Mahony, L 2019, ' Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients ', Nature Communications, vol. 10, 5711 . https://doi.org/10.1038/s41467-019-13751-9
Nature Communications
Michalovich, D, Rodriguez-Perez, N, Smolinska, S, Pirozynski, M, Mayhew, D, Uddin, S, Van Horn, S, Sokolowska, M, Altunbulakli, C, Eljaszewicz, A, Pugin, B, Barcik, W, Kurnik-Lucka, M, Saunders, K A, Simpson, K D, Schmid-Grendelmeier, P, Ferstl, R, Frei, R, Sievi, N, Kohler, M, Gajdanowicz, P, Graversen, K B, Bøgh, K L, Jutel, M, Brown, J R, Akdis, C A, Hessel, E M & O'Mahony, L 2019, ' Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients ', Nature Communications, vol. 10, 5711 . https://doi.org/10.1038/s41467-019-13751-9
In order to improve targeted therapeutic approaches for asthma patients, insights into the molecular mechanisms that differentially contribute to disease phenotypes, such as obese asthmatics or severe asthmatics, are required. Here we report immunolo
Autor:
Aris Polyzos, Dhruba Ghosh, Lila Lovergne, Renaud Schuck, Edward S. Barnard, James B. Brown, Michael C. Martin, Andrew D. Chen, Cynthia T. McMurray
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Although some neurodegenerative diseases can be identified by behavioral characteristics relatively late in disease progression, we currently lack methods to predict who has developed disease before the onset of symptoms, when onset will occur, or th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cde61bed6618f788580805954b312a76
https://escholarship.org/uc/item/58m3f68f
https://escholarship.org/uc/item/58m3f68f
Autor:
Tyler Peryea, Ahsan Habib Polash, Alessandra Roncaglioni, Daniel M. Wilson, Warren Casey, Patricia Ruiz, Nathalie Alépée, Sherif Farag, Giovanna J. Lavado, Kimberley M. Zorn, Alexey V. Zakharov, Davide Ballabio, Katrina M. Waters, Risa Sayre, Giuseppe Felice Mangiatordi, Orazio Nicolotti, Nicole Kleinstreuer, Pankaj R. Daga, Sean Ekins, Kamel Mansouri, Liguo Wang, Judy Strickland, Matthew J. Hirn, Sudin Bhattacharya, Dac-Trung Nguyen, Emilio Benfenati, Ignacio J. Tripodi, Amanda K. Parks, Garett Goh, Dennis G. Thomas, Glenn J. Myatt, Prachi Pradeep, Gergely Zahoranszky-Kohalmi, Anton Simeonov, Arthur C. Silva, Grace Patlewicz, Timothy Sheils, Stephen Boyd, Agnes L. Karmaus, Ahmed Sayed, Alex M. Clark, Todd M. Martin, Pavel Karpov, Jeffery M. Gearhart, Robert Rallo, D Allen, Charles Siegel, Zhen Zhang, Zijun Xiao, Alexander Tropsha, Stephen J. Capuzzi, Alexandru Korotcov, Carolina Horta Andrade, Noel Southall, Viviana Consonni, Igor V. Tetko, Jeremy M. Fitzpatrick, Andrew J. Wedlake, Denis Fourches, Zhongyu Wang, Vinicius M. Alves, Eugene N. Muratov, Timothy E. H. Allen, Andrea Mauri, James B. Brown, Alexandre Varnek, Yun Tang, Sanjeeva J. Wijeyesakere, Daniel P. Russo, Cosimo Toma, Christopher M. Grulke, Michael S. Lawless, Domenico Gadaleta, Paritosh Pande, Thomas Hartung, Jonathan M. Goodman, Kristijan Vukovic, Joyce V. Bastos, Daniela Trisciuzzi, Fagen F. Zhang, Domenico Alberga, Thomas Luechtefeld, Dan Marsh, Tyler R. Auernhammer, Shannon M. Bell, Xinhao Li, Brian J. Teppen, F. Lunghini, Sergey Sosnin, Hao Zhu, Feng Gao, Craig Rowlands, Tongan Zhao, R Todeschini, Valery Tkachenko, Francesca Grisoni, Hongbin Yang, Yaroslav Chushak, Maxim V. Fedorov, Heather L. Ciallella, Gilles Marcou
Publikováno v:
Environmental Health Perspectives
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2021, 129 (4), pp.047013. ⟨10.1289/EHP8495⟩
Environmental Health Perspectives, National Institute of Environmental Health Sciences, 2021, 129 (4), pp.047013. ⟨10.1289/EHP8495⟩
BACKGROUND: Humans are exposed to tens of thousands of chemical substances that need to be assessed for their potential toxicity. Acute systemic toxicity testing serves as the basis for regulatory hazard classification, labeling, and risk management.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f10be9a3f401d14e1b5653e1242ab66
https://www.repository.cam.ac.uk/handle/1810/322114
https://www.repository.cam.ac.uk/handle/1810/322114