Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Itaru Kojima"'
Publikováno v:
Endocrine Journal. 69:487-493
T1R3 is a class C G protein-coupled receptor family member that forms heterodimeric umami and sweet taste receptors with T1R1 and T1R2, respectively, in the taste cells of taste buds. T1R3 is expressed in 3T3-L1 cells in homomeric form and negatively
Autor:
Itaru Kojima, Hiroyuki Morita, Yoshihiko Kitada, Kazuo Kajita, Koichiro Taguchi, Takahide Ikeda, Toshiko Kajita, Tatsuo Ishizuka, Motochika Asano, Masayuki Fuwa
Publikováno v:
The Journal of Endocrinology
Despite extensive investigation, the mechanisms underlying adipogenesis are not fully understood. We previously identified proliferative cells in adipose tissue expressing adipocyte-specific genes, which were named small proliferative adipocytes (SPA
Publikováno v:
The FASEB Journal. 31:1368-1381
We have previously reported that transient receptor potential vanilloid 2 (TRPV2) can be activated by mechanical stimulation, which enhances axonal outgrowth in developing neurons; however, the molecular mechanisms that govern the contribution of TRP
Publikováno v:
Pflugers Archiv : European journal of physiology. 471(4)
Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells was documented. The activation of this receptor by sweet-tasting sucralose mimics several biochemical and functional effe
Autor:
Motochika Asano, Shotaro Kamata, Yoshiko Banno, Toshiko Kajita, Ichiro Mori, Itaru Kojima, Isao Ishii, Tatsuo Ishizuka, Masahiro Yamauchi, Hiroyuki Morita, Mikako Kawashima, Jerold Chun, Takahide Ikeda, Yoshihiko Kitada, Koichiro Taguchi, Kazuo Kajita
Publikováno v:
Endocrinology. 157:1839-1851
Sphingosine 1-phosphate (S1P) is known to regulate insulin resistance in hepatocytes, skeletal muscle cells, and pancreatic β-cells. Among its 5 cognate receptors (S1pr1–S1pr5), S1P seems to counteract insulin signaling and confer insulin resistan
Autor:
Hiroki Matsui, Manabu Ueno, Hiroaki Sunaga, Kenichiro Hara, Itaru Kojima, Hiroaki Masubuchi, Masahiko Kurabayashi, Masahiro Nagasawa, Toshitaka Maeno, Koichi Yamaguchi, Shigeo Wakabayashi, Yuko Iwata
Publikováno v:
BMC Pulmonary Medicine
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-10 (2019)
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-10 (2019)
Background Defective phagocytosis in alveolar macrophages is associated with chronic obstructive pulmonary disease (COPD). Transient receptor potential cation channel subfamily V member 2 (TRPV2), a type of nonselective cation channel pertinent to di
Autor:
Shigeki Takeda, Aya Kurosawa, Itaru Kojima, Michinari Otobe, Hideki Sezutsu, Nobuo Kuwabara, Rina Enomoto, Mizuko Futahashi, Yusuke Inoue, Nozomi Nakajima, Tadahiro Kitamura, Misaki Mashiko, Yoshiaki Nikaido, Osamu Kikuchi, Satoshi Kuroiwa, Kazuya Tooyama, Hiroyuki Osada, Maki Ohsaki, Toshihiko Saheki, Yuko Nakagawa, Tamio Saito
Publikováno v:
European journal of pharmacology. 814
GPBA is a G protein–coupled receptor that is activated by bile acids. Because activation of GPBA leads to increased cAMP levels and secretion of incretins and insulin, GPBA has been proposed as a promising drug target for the treatment of metabolic
Publikováno v:
Diabetes, obesitymetabolism. 19
Glucose is a primary stimulator of insulin secretion. It has been thought that glucose exerts its effect by a mechanism solely dependent on glucose metabolism. We show here that glucose induces rapid Ca
Autor:
Toshiko Kajita, Tsutomu Sasaki, Tatsuo Ishizuka, Ichiro Mori, Itaru Kojima, Kazuo Kajita, Takayuki Hanamoto, Hideyuki Okada, Takashi Sato, Taro Usui, Tadahiro Kitamura, Yoshihiko Kitada, Koichiro Taguchi, Hiroyuki Morita, Takahide Ikeda
Publikováno v:
FEBS Letters. 588:1935-1941
Androgen reduces fat mass, although the underlying mechanisms are unknown. Here, we examined the effect of testosterone on heat production and mitochondrial biogenesis. Testosterone-treated mice exhibited elevated heat production. Treatment with test
Autor:
Mark M. Rasenick, Yuko Nakagawa, Johan Medina, Takeshi Inagaki, Masahiro Nagasawa, Hiroshi Shibata, Yosuke Masubuchi, Itaru Kojima
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 5, p e0176841 (2017)
PLoS ONE, Vol 12, Iss 5, p e0176841 (2017)
We previously reported that 3T3-L1 cells express a functional sweet taste receptor possibly as a T1R3 homomer that is coupled to Gs and negatively regulates adipogenesis by a Gαs-mediated but cAMP-independent mechanism. Here, we show that stimulatio