Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Ilya Bezprozvanny"'
Autor:
Ilya Bezprozvanny, Nina Kraskovskaya
Publikováno v:
Biochemistry (Moscow). 86:471-479
Huntington's disease (HD) is a neurodegenerative, dominantly inherited genetic disease caused by expansion of the polyglutamine tract in the huntingtin gene. At the cellular level, HD is characterized by the accumulation of mutant huntingtin protein
Publikováno v:
Cell Calcium
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 4; Pages: 2274
EB3 protein is expressed abundantly in the nervous system and transiently enters the dendritic spines at the tip of the growing microtubule, which leads to spine enlargement. Nevertheless, the role of dynamic microtubules, and particularly EB3 protei
Autor:
Naglaa Salem El-Sayed, Young-Woo Nam, Polina A. Egorova, Hai Minh Nguyen, Razan Orfali, Mohammad Asikur Rahman, Grace Yang, Heike Wulff, Ilya Bezprozvanny, Keykavous Parang, Miao Zhang
Publikováno v:
J Med Chem
A series of modified N-cyclohexyl-2-(3,5-dimethyl-1H-pyrazol-1-yl)-6-methylpyrimidin-4-amine (CyPPA) analogs were synthesized by replacing the cyclohexane moiety with different 4-substituted cyclohexane rings, tyrosine analogs, or mono- and dihalophe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc12c5c8695688093b98ef187909215
https://europepmc.org/articles/PMC8758555/
https://europepmc.org/articles/PMC8758555/
Autor:
O. L. Vlasova, Evgenii Gerasimov, Anastasia Bolshakova, Pavel M. Balaban, A. A. Borodinova, Ilya Bezprozvanny, A. I. Erofeev
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9613, p 9613 (2021)
Volume 22
Issue 17
International Journal of Molecular Sciences, Vol 22, Iss 9613, p 9613 (2021)
Optogenetics approach is used widely in neurobiology as it allows control of cellular activity with high spatial and temporal resolution. In most studies, optogenetics is used to control neuronal activity. In the present study optogenetics was used t
Autor:
Ilya Bezprozvanny
Publikováno v:
Biochem Biophys Res Commun
Autor:
Polina A. Egorova, Ilya Bezprozvanny
Publikováno v:
Neurotherapeutics
The effective therapeutic treatment and the disease-modifying therapy for spinocerebellar ataxia type 2 (SCA2) (a progressive hereditary disease caused by an expansion of polyglutamine in the ataxin-2 protein) is not available yet. At present, only s
Autor:
Jun Wu, Michael R. Hayden, Dabin Kim, Ilya Bezprozvanny, Daniel A. Ryskamp, Michal Geva, Gerhard Rammes, Lili Wu
Publikováno v:
Neurobiology of Disease, Vol 124, Iss, Pp 489-504 (2019)
There is evidence that cognitive decline in Alzheimer's disease (AD) results from deficiencies in synaptic communication (e.g., loss of mushroom-shaped ‘memory spines’) and neurodegenerative processes. This might be treated with sigma-1 receptor
Publikováno v:
Antioxidants & Redox Signaling. 29:1176-1188
Significance: Calcium (Ca(2+)) hypothesis of Alzheimer's disease (AD) gains popularity. It points to new signaling pathways that may underlie AD pathogenesis. Based on calcium hypothesis, novel targets for the development of potential AD therapies ar
Publikováno v:
Cell Calcium
Cerebellar Purkinje cells (PCs) fire spontaneously in a tonic mode, although the precision of this pacemaking activity is disturbed in many abnormal conditions involving cerebellar atrophy, such as many spinocerebellar ataxias (SCAs). In our previous