Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hua-Jun Wu"'
Autor:
Timothy J. Mitchison, Al Charest, Keith L. Ligon, Ennio Antonio Chiocca, Aron Gyuris, Alan T. Yeo, Franziska Michor, Jann N. Sarkaria, Ichiro Nakano, Hua-Jun Wu, Agnieszka Bronisz, Steve P. Gygi, Roderick T. Bronson, Bethany Delcuze, Charlotte E. Lee, Steve Woolfenden, Javier Pineda, Hyun Jung Jun, Christopher M. Rose, Haihao Zhu, Vicky A. Appleman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature Communications
Nature Communications
Glioblastoma multiforme (GBM) is an aggressive primary brain cancer that includes focal amplification of PDGFRα and for which there are no effective therapies. Herein, we report the development of a genetically engineered mouse model of GBM based on
Autor:
Tatsuya Ozawa, Ross L. Levine, Hua-Jun Wu, Jiguang Wang, Julio Vazquez, Franziska Michor, Jes Alexander, Raul Rabadan, Patrick J. Cimino, Hans-Georg Wirsching, Kenneth L. Pitter, Sonali Arora, Eric C. Holland, Frank Szulzewsky, Youngmi Kim
Publikováno v:
Genes & Development. 32:512-523
Glioblastoma is the most frequently occurring and invariably fatal primary brain tumor in adults. The vast majority of glioblastomas is characterized by chromosomal copy number alterations, including gain of whole chromosome 7 and loss of whole chrom
Autor:
Richard L. Bennett, Jonathan D. Licht, Hua-Jun Wu, Leonard B. Maggi, Jason D. Weber, Michael H. Tomasson, Catalina Troche, Nitin Mahajan
Publikováno v:
The FASEB Journal. 31:482-490
Overexpression of the multiple myeloma set domain (MMSET) Wolf-Hirschhorn syndrome candidate 1 gene, which contains an orphan box H/ACA class small nucleolar RNA, ACA11, in an intron, is associated with several cancer types, including multiple myelom
Publikováno v:
PLoS Computational Biology, Vol 16, Iss 11, p e1008452 (2020)
PLoS Computational Biology
PLoS Computational Biology
Deconvolution of heterogeneous bulk tumor samples into distinct cellular populations is an important yet challenging problem, particularly when only partial references are available. A common approach to dealing with this problem is to deconvolve the
Autor:
Paloma Cejas, Jayati Anand, Jason S. Carroll, James E. Bradner, Tom O. McDonald, Sudeepa Syamala, Xintao Qiu, Evangelia K. Papachristou, Katherine Murphy, Hua-Jun Wu, Isaac S. Harris, Alba Font-Tello, Joan S. Brugge, Kornelia Polyak, X. Shirley Liu, Klothilda Lim, Cigall Kadoch, Jaime M. Reyes, Tengfei Xiao, Quang-Dé Nguyen, Kai W. Wucherpfennig, Rhamy Zeid, Brittany C. Michel, Clive D'Santos, Myles Brown, Wei Li, Adrienne M. Luoma, Binbin Wang, Jennifer Y Ge, Kunihiko Hinohara, Jennifer E. Endress, Jacob D. Jaffe, Chandra Sekhar Reddy Chilamakuri, Shaokun Shu, Jun Qi, Rebecca Modiste, Bojana Jovanovic, Franziska Michor, Henry W. Long
Publikováno v:
Molecular Cell. 78:1096-1113.e8
BET bromodomain inhibitors (BBDIs) are candidate therapeutic agents for triple-negative breast cancer (TNBC) and other cancer types, but inherent and acquired resistance to BBDIs limits their potential clinical use. Using CRISPR and small-molecule in
Autor:
Xiu-Jie Wang, Zhonghua Liu, Zhen Xu, Qi Zhou, Zhiguo Chen, Lei Liu, Wei Li, Hua-Jun Wu, Chang-long Guo, Jianyu Wu, Liu Wang, Libin Wang, Chao Sheng, Qinyuan Zheng, Xiaoyang Zhao, Haijiang Zhang, Shigang He, Ziwei Wang
Publikováno v:
Cell Research. 22:208-218
Multipotent neural stem/progenitor cells hold great promise for cell therapy. The reprogramming of fibroblasts to induced pluripotent stem cells as well as mature neurons suggests a possibility to convert a terminally differentiated somatic cell into
Autor:
Man Tong, Haijiang Zhang, Jiahao Sha, Hua-Jun Wu, Lei Liu, Fanyi Zeng, Qi Zhou, Yibo Wu, Zhuo Lv, Qinyuan Zheng, Zhikun Li, Hui Zhu, Liu Wang, Wei Li, Xiaoyang Zhao, Xiu-Jie Wang
Publikováno v:
Cell Research. 21:1634-1637
Mice generated from tetraploid complementation competent iPS cells show similar developmental features as those from ES cells but are prone to tumorigenesis
Activation of the Imprinted Dlk1-Dio3 Region Correlates with Pluripotency Levels of Mouse Stem Cells
Autor:
Xiaoyang Zhao, Xiu-Jie Wang, Hua-Jun Wu, Zhuo Lv, Qi Zhou, Guan-Zheng Luo, Liu Wang, Wei Li, Wei Yang, Lei Liu, Qinyuan Zheng
Publikováno v:
The Journal of Biological Chemistry
Low reprogramming efficiency and reduced pluripotency have been the two major obstacles in induced pluripotent stem (iPS) cell research. An effective and quick method to assess the pluripotency levels of iPS cells at early stages would significantly
Autor:
Lisi Sang, Xiu-Jie Wang, Hua-Jun Wu, Tianda Li, Qinyuan Zheng, Lei Liu, Chunjing Feng, Chao Sheng, Haifeng Wan, Wei Li, Liu Wang, Mingzhu Dong, Xin Li, Zhonghua Liu, Guan-Zheng Luo, Meng Wang, Xiaoyang Zhao, Ling Shuai, Qi Zhou, Libin Wang
Publikováno v:
Nature. 490(7420)
Haploids and double haploids are important resources for studying recessive traits and have large impacts on crop breeding, but natural haploids are rare in animals. Mammalian haploids are restricted to germline cells and are occasionally found in tu
Publikováno v:
Comparative biochemistry and physiology. Part B, Biochemistrymolecular biology. 146(1)
We examined the relative importance of behavioral thermoregulation and metabolic compensation used by a subtropical rhacophorid (Polypedates megacephalus) tadpoles living in man-made container habitats to cope with thermal stress. We collected foam n