Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hitomi Sakai"'
Autor:
Kaoru Tanaka, Ryoji Kato, Hitomi Sakai, Masayuki Takeda, Kimio Yonesaka, Hisato Kawakami, Kazuhiko Nakagawa, Koji Haratani, Hidetoshi Hayashi, Kazuto Nishio, Kazuko Sakai
Publikováno v:
British Journal of Cancer
Background Cancer-associated fibroblasts (CAFs) in the tumour microenvironment (TME) suppress antitumour immunity, and the tyrosine kinase inhibitor nintedanib has antifibrotic effects. Methods We performed a preclinical study to evaluate whether nin
Autor:
Keiji Furuuchi, Toshimitsu Uenaka, Ryoji Kato, Hitomi Sakai, Yuta Onodera, Elizabeth B. Somers, Hisato Kawakami, Takeshi Teramura, Kazuhiko Nakagawa
Publikováno v:
Clinical and Translational Medicine
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Clinical and Translational Medicine, Vol 11, Iss 6, Pp n/a-n/a (2021)
Background The main function of folate receptor α (FOLRα) has been considered to mediate intracellular folate uptake and induce tumor cell proliferation. Given the broad spectrum of expression among malignant tumors, including gastric cancer (GC) b
Autor:
Shinichiro, Suzuki, Kimio, Yonesaka, Takeshi, Teramura, Toshiyuki, Takehara, Ryoji, Kato, Hitomi, Sakai, Koji, Haratani, Junko, Tanizaki, Hisato, Kawakami, Hidetoshi, Hayashi, Kazuko, Sakai, Kazuto, Nishio, Kazuhiko, Nakagawa
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 27(20)
Treatment withClones of sotorasib-sensitiveUnbiased screening detected subclonal evolution of
Autor:
Toshiro Takedomi, Satoru Moriyasu, Akira Naito, Takashi Fujii, Soichi Kageyama, Hiroki Hirayama, Hitomi Sakai, Masahito Sugimoto
Publikováno v:
The Journal of Veterinary Medical Science
We investigated the effects of genetic background on the responses to superovulation in Japanese Black cattle. The genotype frequencies of GRIA1 and FSHR relating to ovulation and follicular development in each of the major bloodlines—Tajiri, Fujiy
Autor:
Koji Haratani, Yasutaka Chiba, Shiki Takamura, Takafumi Okabe, Kenji Hirotani, Hiroyasu Kaneda, Michiko Yamato, Kaoru Tanaka, Shigeki Kato, Kazuhiko Nakagawa, Kazuto Nishio, Hidetoshi Hayashi, Yoshikazu Hasegawa, Masayuki Takeda, Kazuko Sakai, Kimio Yonesaka, Masaaki Miyazawa, Osamu Maenishi, Ryoji Kato, Naoki Takegawa, Takayuki Takahama, Hitomi Sakai, Keita Kudo
Publikováno v:
Clinical Cancer Research. 24:2653-2664
Purpose: Anti-programmed-death-1 (PD-1) immunotherapy improves survival in non–small cell lung cancer (NSCLC), but some cases are refractory to treatment, thereby requiring alternative strategies. B7-H3, an immune-checkpoint molecule, is expressed
Autor:
Mai Hirokawa, Tomomi Akita, Hitomi Sakai, Michiko Horiguchi, Isao Tachibana, Harumi Kumagai, Yoshito Takeda, Yuki Oiso, Norikazu Maeda, Chikamasa Yamashita, Chihiro Ozawa
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 361:501-505
Chronic obstructive pulmonary disease (COPD) is an intractable pulmonary disease that causes widespread and irreversible alveolar collapse. Although COPD occurs worldwide, only symptomatic therapy is currently available. Our objective is the developm
Autor:
Masashi Kashima, Takashi Fujii, Akira Naito, Hitomi Yoshino, Shigeo Fukuda, Shuichi Matsuyama, Hiroyuki Hayakawa, Y. Sugimoto, Hiroki Hirayama, Hitomi Sakai, Soichi Kageyama, Satoru Moriyasu, Koji Kimura
Publikováno v:
The Journal of Reproduction and Development
Preimplantation genomic selection based on single nucleotide polymorphism (SNP) genotypes is expected to accelerate genetic improvement in cattle. However, genome-wide genotyping at the early embryonic stage has several limitations, such as the techn
Publikováno v:
Journal of Controlled Release. 187:167-174
Chronic obstructive pulmonary disease (COPD) is an intractable pulmonary disease, causes widespread and irreversible alveoli collapse. In search of a treatment target molecule, which is able to regenerate collapsed alveoli, we sought to identify a fa
Autor:
Mitsuko Shinohara, Hitomi Sakai, Koji Kato, Kiyoshi Ohura, Kozue Edo, Kuniko Nagasaka, Futoshi Iwaki, Haruhiko Sakuraba, Hideyuki Nakagawa
Publikováno v:
Journal of Pharmacological Sciences, Vol 113, Iss 4, Pp 414-417 (2010)
A chemoattractant lectin from the dorsal spines of the redfin velvetfish, Hypodytes rubripinnis, was isolated using a combination of affinity chromatography techniques. The glycoprotein, with a molecular mass of 110 kDa, is named Karatoxin. Karatoxin
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 213
Chronic obstructive pulmonary disease (COPD) is an intractable pulmonary disease, causing widespread and irreversible alveoli collapse. The discovery of a low-molecular-weight compound that induces regeneration of pulmonary alveoli is of utmost urgen