Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Herbert J. Zeh"'
Autor:
Runliu Wu, Daniel J. Klionsky, Daolin Tang, Xin Chen, Jingbo Li, Xinxin Song, Herbert J. Zeh, Yinghua Xu, Xiaoyan Wang, Rui Kang, Jiao Liu
Publikováno v:
Autophagy
Macroautophagy (hereafter referred to as “autophagy”) is a lysosome-mediated degradation process that plays a complex role in cellular stress, either promoting survival or triggering death. Early studies suggest that ferroptosis, an iron-dependen
Autor:
Enyong Dai, Leng Han, Yangchun Xie, Jiao Liu, Rui Kang, Herbert J. Zeh, Daolin Tang, Lulu Bai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Nature Communications
Nature Communications
Ferroptosis is a more recently recognized form of cell death that relies on iron-mediated oxidative damage. Here, we evaluate the impact of high-iron diets or depletion of Gpx4, an antioxidant enzyme reported as an important ferroptosis suppressor, i
Publikováno v:
Autophagy
Oncogenic KRAS mutation-driven pancreatic ductal adenocarcinoma is currently the fourth-leading cause of cancer-related deaths in the United States. Macroautophagy (hereafter “autophagy”) is one of the lysosome-dependent degradation systems that
Autor:
Jun Huang, Ke Liu, Guido Kroemer, Changfeng Li, Borong Zou, Daolin Tang, Rui Kang, Jiao Liu, Herbert J. Zeh
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2022, 13 (2), pp.483-500. ⟨10.1016/j.jcmgh.2021.09.008⟩
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 483-500 (2022)
Cellular and Molecular Gastroenterology and Hepatology, Philadelphia, PA : American Gastroenterological Association, [2015]-, 2022, 13 (2), pp.483-500. ⟨10.1016/j.jcmgh.2021.09.008⟩
Cellular and Molecular Gastroenterology and Hepatology, Vol 13, Iss 2, Pp 483-500 (2022)
Background & Aims Pancreatitis is characterized by acinar cell death and persistent inflammation. Ferroptosis is a type of lipid peroxidation-dependent necrosis, which is negatively regulated by glutathione peroxidase 4. We studied how trypsin, a ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2672294190e99060699bb76afc1e37a6
https://hal.sorbonne-universite.fr/hal-03549632/file/1-s2.0-S2352345X2100196X-main.pdf
https://hal.sorbonne-universite.fr/hal-03549632/file/1-s2.0-S2352345X2100196X-main.pdf
Autor:
Herbert J. Zeh, Farzad Esni, Zobeida Cruz-Monserrate, Jing Hu, Michael T. Lotze, Mairobys Socorro, George K. Gittes, Vincent Goffin, Gina M. Coudriet, Aatur D. Singhi, Mouhanned Eliliwi, Andrew V. Biankin, Peter Bailey, Angela Criscimanna, Manuj Tandon
Publikováno v:
Cancer Research. 79:5316-5327
Pancreatic ductal adenocarcinoma (PDAC) is associated with significant fibrosis. Recent findings have highlighted the profibrotic activity of tissue-resident macrophages in the pancreatic cancer microenvironment. Here, we show that neoplastic pancrea
Autor:
John D. Karalis, Lynn Y. Yoon, Suntrea T. G. Hammer, Changjin Hong, Min Zhu, Ibrahim Nassour, Michelle R. Ju, Shu Xiao, Esther C. Castro-Dubon, Deepak Agrawal, Jorge Suarez, Scott I. Reznik, John C. Mansour, Patricio M. Polanco, Adam C. Yopp, Herbert J. Zeh, Tae Hyun Hwang, Hao Zhu, Matthew R. Porembka, Sam C. Wang
Publikováno v:
Journal of translational medicine. 20(1)
Background Lenvatinib is a multitargeted tyrosine kinase inhibitor that is being tested in combination with immune checkpoint inhibitors to treat advanced gastric cancer; however, little data exists regarding the efficacy of lenvatinib monotherapy. P
Autor:
Herbert J. Zeh, Meinrad Gawaz, Jennifer L. Miller-Ocuin, Michael T. Lotze, Xiaoyan Liang, Kira L. Russell, Pranav Murthy, Brian A. Boone, Sebastian Vogel, Patricia Loughran
Publikováno v:
Ann Hematol
Platelets are activated in solid cancers, including pancreatic ductal adenocarcinoma (PDA), a highly aggressive malignancy with a devastating prognosis and limited therapeutic options. The mechanisms by which activated platelets regulate tumor progre
Autor:
Herbert J. Zeh, Ulka Sachdev, Sebastian Vogel, Xiangdong Cui, Pranav Murthy, Michael T. Lotze
Publikováno v:
Biochemical and Biophysical Research Communications. 508:614-619
Platelets play a critical role in the pathophysiology of peripheral arterial disease (PAD). The mechanisms by which muscle ischemia regulates aggregation of platelets are poorly understood. We have recently identified the Nod-like receptor nucleotide
Autor:
Xinxin Song, Xin Chen, Feimei Kuang, Daolin Tang, Herbert J. Zeh, Jiao Liu, Rui Kang, Guido Kroemer, Yangchun Xie
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108767-(2021)
Cell Reports
Cell Reports, Elsevier Inc, 2021, 34 (8), pp.108767. ⟨10.1016/j.celrep.2021.108767⟩
Cell Reports, 2021, 34 (8), pp.108767. ⟨10.1016/j.celrep.2021.108767⟩
Cell Reports
Cell Reports, Elsevier Inc, 2021, 34 (8), pp.108767. ⟨10.1016/j.celrep.2021.108767⟩
Cell Reports, 2021, 34 (8), pp.108767. ⟨10.1016/j.celrep.2021.108767⟩
International audience; Although induction of ferroptosis, an iron-dependent form of non-apoptotic cell death, has emerged as an anticancer strategy, the metabolic basis of ferroptotic death remains poorly elucidated. Here, we show that glucose deter
Autor:
Daolin Tang, Ling Zeng, Daniel J. Klionsky, Borong Zhou, Shan Zhu, Jianxin Jiang, Timothy R. Billiar, Guido Kroemer, Haichao Wang, Jiao Liu, Herbert J. Zeh, Rui Kang
Publikováno v:
Autophagy
Sepsis is the most common cause of death for patients in intensive care worldwide due to a dysregulated host response to infection. Here, we investigate the role of sequestosome-1 (SQSTM1/p62), an autophagy receptor that functions as a regulator of i