Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Han Moshage"'
Publikováno v:
Toxicology and Applied Pharmacology, 436:115858. ACADEMIC PRESS INC ELSEVIER SCIENCE
BACKGROUND: The number of patients with non-alcoholic fatty liver disease (NAFLD) is rapidly increasing due to the growing epidemic of obesity. Non-alcoholic steatohepatitis (NASH), the inflammatory stage of NAFLD, is characterized by lipid accumulat
Autor:
Robert J. Porte, Ton Lisman, Masato Fujiyoshi, Andrie C. Westerkamp, Henri G. D. Leuvenink, Han Moshage, Petra J. Ottens, Tim A Berendsen, Vincent E de Meijer, Maarten W. N. Nijsten, Daan J Touw
Publikováno v:
Transplantation
Transplantation, 104(9), E271-E280. LIPPINCOTT WILLIAMS & WILKINS
Transplantation, 104(9), E271-E280. LIPPINCOTT WILLIAMS & WILKINS
Background. Preconditioning of donor livers before organ retrieval may improve organ quality after transplantation. We investigated whether preconditioning with metformin reduces preservation injury and improves hepatobiliary function in rat donor li
Autor:
Mengfan Zhang, Harry van Goor, Manon Buist-Homan, Klaas Nico Faber, Turtushikh Damba, Han Moshage
Publikováno v:
Nitric oxide-Biology and chemistry, 92(1), 26-33. ACADEMIC PRESS INC ELSEVIER SCIENCE
Hepatic fibrosis is caused by chronic inflammation and characterized as the excessive accumulation of extra cellular matrix (ECM) by activated hepatic stellate cells (HSCs). Gasotransmitters like NO and CO are known to modulate inflammation and fibro
Autor:
Tatiana Alieva, Han Moshage, José Rodrigo, Yana Geng, Fabio Alejandro Aguilar Mora, Johanna C. Arroyave Ospina, Manon Buist-Homan, Juan M. Soto, Nshunge Musheshe, Xiaodong Cheng, Martina Schmidt, Frank Lezoualc'h
Publikováno v:
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 143:112072. ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Biomedicine & Pharmacotherapy, Vol 143, Iss, Pp 112072-(2021)
E-Prints Complutense. Archivo Institucional de la UCM
instname
Biomedicine & Pharmacotherapy, Vol 143, Iss, Pp 112072-(2021)
E-Prints Complutense. Archivo Institucional de la UCM
instname
Background and purpose: It has been shown that the antidiabetic drug metformin protects hepatocytes against toxicity by various stressors. Chronic or excessive consumption of diclofenac (DF) - a pain-relieving drug, leads to drug-induced liver injury
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7185ab4e03487345d9aa34794125fd4f
https://research.rug.nl/en/publications/024bf9d2-cd71-465b-9948-bd4b11544155
https://research.rug.nl/en/publications/024bf9d2-cd71-465b-9948-bd4b11544155
Publikováno v:
Scientific Reports, 11(1):12151. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports
Although retinal microvessels (RMVs) and brain microvessels (BMVs) are closely related in their developmental and share similar blood-neural barriers, studies have reported markedly different responses to stressors such as diabetes. Therefore, we hyp
Autor:
Manon Buist-Homan, Martina Schmidt, Xiaodong Cheng, Nshunge Musheshe, Han Moshage, Asmaa Oun, Frank Lezoualc'h, Fabio Alejandro Aguilar Mora
Publikováno v:
Molecular Pharmacology, 99(4), 294-307. AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
Chronic consumption of the nonsteroidal anti-inflammatory drug diclofenac may induce drug-induced liver injury (DILI). The mechanism of diclofenac-induced liver injury is partially elucidated and involves mitochondrial damage. Elevated cAMP protects
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d903dcd36acfd563ce863b791bae9b
https://research.rug.nl/en/publications/ccfe63f0-a10f-4519-a0d4-29a34c2d366e
https://research.rug.nl/en/publications/ccfe63f0-a10f-4519-a0d4-29a34c2d366e
Autor:
Klaas Nico Faber, Janette Heegsma, Svenja Sydor, Han Moshage, Karen van Eunen, Lars P Bechmann, Natalia Smith-Cortinez, Barbara M. Bakker, Sandra Alejandra Serna-Salas
Publikováno v:
Cells, Vol 9, Iss 2456, p 2456 (2020)
Cells, 9(11):2456. MDPI AG
Cells
Volume 9
Issue 11
Cells, 9(11):2456. MDPI AG
Cells
Volume 9
Issue 11
Upon liver injury, hepatic stellate cells (HSCs) transdifferentiate to migratory, proliferative and extracellular matrix-producing myofibroblasts (e.g., activated HSCs
aHSCs) causing liver fibrosis. HSC activation is associated with increased gl
aHSCs) causing liver fibrosis. HSC activation is associated with increased gl
Autor:
Sandra A. Serna-Salas, Johanna C. Arroyave-Ospina, Mengfan Zhang, Turtushikh Damba, Manon Buist-Homan, Martin H. Muñoz-Ortega, Javier Ventura-Juárez, Han Moshage
Publikováno v:
Mechanisms of Ageing and Development, 201:111617. ELSEVIER IRELAND LTD
BACKGROUND: Activated hepatic stellate cells (aHSCs) are the main effector cells during liver fibrogenesis. α-1 adrenergic antagonist doxazosin (DX) was shown to be anti-fibrotic in an in vivo model of liver fibrosis (LF), but the mechanism remains
Autor:
Alejandra Hernandez, Han Moshage, Francisco Barrera, Javiera Torres, Nancy Solís, Juan Pablo Arab, Rolando Sepulveda, Marco Arrese, Yana Geng, Daniel Cabrera
Publikováno v:
Biochimica et biophysica acta-Molecular basis of disease, 1866(6):165753. ELSEVIER SCIENCE BV
BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is associated to intermittent hypoxia (IH) and is an aggravating factor of non-alcoholic fatty liver disease (NAFLD). We investigated the effects of hypoxia in both in vitro and in vivo models of NA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ff9529d14ddbe637ddaeb3639274ac
https://research.rug.nl/en/publications/f6926124-f103-4f68-80df-a07e24f45da7
https://research.rug.nl/en/publications/f6926124-f103-4f68-80df-a07e24f45da7
Publikováno v:
Toxicology and Applied Pharmacology, 404:115183. ACADEMIC PRESS INC ELSEVIER SCIENCE
Lipotoxicity plays a critical role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD). Hesperetin, a flavonoid derivative, has anti-oxidant, anti-inflammatory and cytoprotective properties. In the present study, we aim to examine whethe