Zobrazeno 1 - 7
of 7
pro vyhledávání: '"H. H. Schmeiser"'
Publikováno v:
General physiology and biophysics. 20(3)
2-Methoxyaniline (o-anisidine) is a urinary bladder carcinogen in both mice and rats. Since the urinary bladder contains substantial peroxidase activity, we examined the ability of prostaglandin H synthase (PHS), a prominent enzyme in the urinary bla
Publikováno v:
IARC scientific publications. (124)
Binding of the naturally occurring carcinogen, aristolochic acid I (AAI), to DNA in male Wistar rats has been examined. Rats were treated orally with a single dose (13.8 mmol) of AAI and sacrificed 1 day and 1, 2, 4, 16 and 36 weeks after treatment.
Publikováno v:
IARC scientific publications. (124)
The tobacco-specific nitrosamine, 4-(N-nitrosomethylamino)-1-(3-pyridyl)- 1-butanone (NNK) can be activated to DNA-binding species by two pathways: methylene hydroxylation leads to an equimolar formation of methyldiazohydroxide and 4-oxo-4-(3-pyridyl
Publikováno v:
General physiology and biophysics. 11(5)
Carcinogenic azo dyes (dimethylaminoazobenzene, Sudan I) and N-nitrosamines (N-nitrosomethylaniline, N-nitrosomethylbenzylamine) are oxidized by cytochrome P-450 isoenzymes and peroxidase yielding metabolites which in vitro bind to DNA and transfer R
Publikováno v:
Progress in experimental tumor research. 34
Publikováno v:
Carcinogenesis. 11(10)
Horseradish peroxidase in the presence of hydrogen peroxide mediates the activation of carcinogenic 1-phenylazo-2-hydroxynaphthalene (Sudan I) to DNA-bound products in vitro. The peroxidase activating system is greater than 10 times more effective wi
Autor:
H H, Schmeiser, J W, Janssen, J, Lyons, H R, Scherf, W, Pfau, A, Buchmann, C R, Bartram, M, Wiessler
Publikováno v:
Cancer research. 50(17)
Aristolochic acid I (AAI), a nitrophenanthrene derivative, is the major component of the carcinogenic plant extract aristolochic acid, which has been used as a medicine since antiquity. Long term oral administration of AAI to male Wistar rats induces