Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Graeme J. Koelwyn"'
Autor:
Liqian Ma, Hashni Epa Vidana Gamage, Srishti Tiwari, Chaeyeon Han, Madeline A Henn, Natalia Krawczynska, Payam Dibaeinia, Graeme J Koelwyn, Anasuya Das Gupta, Rafael Ovidio Bautista Rivas, Chris L Wright, Fangxiu Xu, Kathryn J Moore, Saurabh Sinha, Erik R Nelson
Publikováno v:
Endocrinology
Dysregulation of cholesterol homeostasis is associated with many diseases such as cardiovascular disease and cancer. Liver X receptors (LXRs) are major upstream regulators of cholesterol homeostasis and are activated by endogenous cholesterol metabol
Publikováno v:
Nat Metab
Unhealthful lifestyle factors, such as obesity, disrupt organismal homeostasis and accelerate cancer pathogenesis, partly through metabolic and immunological dysregulation. Exercise is a prototypical strategy that maintains and restores homeostasis a
Autor:
Ann Marie Schmidt, Martin Schlegel, Alexandra A. C. Newman, Monika Sharma, Emma M Corr, Yannick Cyr, Coen van Solingen, Lianne C Shanley, Kathryn J. Moore, Milessa Silva Afonso, Emily J. Brown, Jonathan Guzman, Rubab Farhat, Graeme J. Koelwyn, Cyrus A Nikain, Edward A. Fisher, Daniel Peled
Publikováno v:
Circ Res
Rationale:Therapeutic efforts to decrease atherosclerotic cardiovascular disease risk have focused largely on reducing atherogenic lipoproteins, yet lipid-lowering therapies alone are insufficient to fully regress plaque burden. We postulate that art
Autor:
Edward A. Fisher, Martin Schlegel, Daniel Peled, Lauren Beckett, Alireza Khodadadi-Jamayran, Kathryn J. Moore, Lianne C Shanley, Huilin Li, Chiara Giannarelli, Coen van Solingen, Monika Sharma, Graeme J. Koelwyn, Karishma Rahman, Emily J. Brown, Milessa Silva Afonso
Publikováno v:
Circ Res
Rationale: MicroRNA-33 (miR-33 [post-transcriptionally in the rationale]) post-transcriptionally represses genes involved in lipid metabolism and energy homeostasis. Targeted inhibition of miR-33 increases plasma HDL (high-density lipoprotein) choles
Autor:
Michele Silvestro, Kamelia Drenkova, Matthias Nahrendorf, Angela Lee, Florencia Schlamp, Bhama Ramkhelawon, Filip K. Swirski, Graeme J. Koelwyn, Fazli Bozal, Tessa J. Barrett, Jeffrey S. Berger, Annika de Jong, Emma M Corr, Alexandra A. C. Newman, Coen van Solingen, Harmony R. Reynolds, Edward A. Fisher, Judith S. Hochman, Lianne C Shanley, Emily J. Brown, Tanya M. Spruill, Kathryn J. Moore
Publikováno v:
Cell reports. 36(10)
Psychological stress (PS) is associated with systemic inflammation and accelerates inflammatory disease progression (e.g., atherosclerosis). The mechanisms underlying stress-mediated inflammation and future health risk are poorly understood. Monocyte
Autor:
Emily J. Brown, Matthew Spite, Brian E. Sansbury, Lianne C Shanley, Graeme J. Koelwyn, Martin Schlegel, Ada Weinstock, Milessa Silva Afonso, Juan J. Lafaille, Edward A. Fisher, Karishma Rahman, Daniel Peled, Kathryn J. Moore, Monika Sharma, Emma M Corr, P'ng Loke, Lauren Beckett, Coen van Solingen
Publikováno v:
Circ Res
Rationale: Regression of atherosclerosis is an important clinical goal; however, the pathways that mediate the resolution of atherosclerotic inflammation and reversal of plaques are poorly understood. Regulatory T cells (Tregs) have been shown to be
Autor:
Monika Sharma, Ravichandran Ramasamy, Tarik Hadi, Ludovic Boytard, Edward A. Fisher, Bhama Ramkhelawon, Susan Hutchison, Westley Spiro, Bo Yan, Lena Seifert, Russell Simon, Graeme J. Koelwyn, Mireille Ouimet, Kathryn J. Moore
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
During obesity, macrophages infiltrate the visceral adipose tissue and promote inflammation that contributes to type II diabetes. Evidence suggests that the rewiring of cellular metabolism can regulate macrophage function. However, the metabolic prog
Autor:
Lee W. Jones, Valeria Mezzano, Daniela F. Quail, Kathryn J. Moore, Karishma Rahman, Emily J. Brown, Graeme J. Koelwyn, Jonathan D. Newman, Bette J. Caan, Edward A. Fisher, David S. Park, Lianne C Shanley, Naoko Yamaguchi, Erik R. Nelson, Kathleen B. Albers, Deven Narke, Alexandra A. C. Newman, Coen van Solingen, Milessa Silva Afonso, P. Martin Schlegel, Tessa J. Barrett, Monika Sharma, Emma M Corr
Publikováno v:
Nat Med
Disruption of systemic homeostasis by either chronic or acute stressors, such as obesity(1) or surgery(2), alters cancer pathogenesis. Cancer patients, particularly those with breast cancer, can be at increased risk for cardiovascular disease due to
Autor:
Graeme J. Koelwyn, Kathryn J. Moore
Publikováno v:
Trends in Immunology. 40:179-181
Macrophages in the heart have dual roles in injury and repair after myocardial infarction, and understanding the two sides of this coin using traditional 'bulk cell' technologies has been challenging. By combining genetic fate-mapping and single-cell
Publikováno v:
Nature immunology. 19(6)
After activation, cells of the myeloid lineage undergo robust metabolic transitions, as well as discrete epigenetic changes, that can dictate both ongoing and future inflammatory responses. In atherosclerosis, in which macrophages play central roles