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pro vyhledávání: '"Eric B. Keverne"'
Autor:
Eric B. Keverne
Publikováno v:
Epigenomics. 3:183-191
Fundamental aspects of mammalian brain evolution occurred in the context of viviparity and placentation brought about by the epigenetic regulation of imprinted genes. Since the fetal placenta hormonally primes the maternal brain, two genomes in one i
Publikováno v:
Neuroscience. 169:1462-1472
Vomeronasal neurons undergo continuous neurogenesis throughout development and adult life. These neurons originate as stem cells in the apical zone of the lumen of the vomeronasal organ (VNO) and are described as nestin-expressing glia-like progenito
Autor:
Eric B. Keverne
Publikováno v:
Neurotoxicity Research. 18:386-392
Genomic imprinting is a widespread epigenetic phenomenon in mammals and many imprinted genes are expressed in the developing hypothalamus and placenta. The placenta and brain are very different structures with very different roles, but in the pregnan
Autor:
William T. Swaney, Eric B. Keverne
Publikováno v:
Behavioural Brain Research. 200:239-247
Small-brained rodents have been the principle focus for pheromonal research and have provided comprehensive insights into the chemosensory mechanisms that underpin pheromonal communication and the hugely important roles that pheromones play in behavi
Publikováno v:
Developmental Neurobiology. 69:314-325
Inactivation of the maternally imprinted, paternally expressed gene 3 (Peg3) induces deficits in olfactory function, sexual and maternal behaviors, oxytocin neuron number, metabolic homeostasis and growth. Peg3 is expressed in a number of developing
Publikováno v:
Behavioral Neuroscience. 123:469-480
Genomic imprinting represents a mechanism through which parent-of-origin effects on offspring development may be mediated. However, investigation of the influence of imprinted genes on behavior has been limited. Here the authors investigate the role
Autor:
Eric B. Keverne
Publikováno v:
BioEssays. 30:802-805
Mammalian vomeronasal receptors respond to pheromones conveying information on gender, reproductive status and individual recognition. The question arises as to how this information is coded, which parts of the code require combinatorial activity and
Autor:
James P. Curley, Eric B. Keverne
Publikováno v:
Frontiers in Neuroendocrinology. 29:398-412
Molecular modifications to the structure of histone proteins and DNA (chromatin) play a significant role in regulating the transcription of genes without altering their nucleotide sequence. Certain epigenetic modifications to DNA are heritable in the
Publikováno v:
Physiology & Behavior. 91:325-334
The role of maternal care in mediating variation in offspring phenotype has been examined in the rat and demonstrates that mother-infant interactions are critical for inducing long-term changes in behavior. Though phenotypic differences between mice
Publikováno v:
Proceedings of the National Academy of Sciences. 104:6084-6089
Mammalian imprinted genes are generally thought to have evolved as a result of conflict between parents; however, recent knockout studies suggest that coadaptation between mother and offspring may have been a significant factor. We present evidence t