Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Cubitt, A"'
Autor:
Stephens, Amberley D, Villegas, Ana Fernandez, Chung, Chyi Wei, Vanderpoorten, Oliver, Pinotsi, Dorothea, Mela, Ioanna, Ward, Edward, McCoy, Thomas M, Cubitt, Robert, Routh, Alexander F, Kaminski, Clemens F, Kaminski Schierle, Gabriele S
Publikováno v:
Communications Biology, 6
Monomeric alpha-synuclein (aSyn) is a well characterised protein that importantly binds to lipids. aSyn monomers assemble into amyloid fibrils which are localised to lipids and organelles in insoluble structures found in Parkinson's disease patient's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4baa7f119b85759d35dccc34ca72fcad
Publikováno v:
Virology. 576
The mammarenavirus Lassa virus (LASV) causes a life-threatening acute febrile disease, Lassa fever (LF). To date, no US Food and Drug Administration (FDA)-licensed medical countermeasures against LASV are available. This underscores the need for the
Autor:
Elia D. Tait-Wojno, Dipak Kumar Sahoo, Ajeet Singh, Matt Kanke, Christopher M. Dekaney, Natasza A. Kurpios, Rebecca L. Cubitt, Bailey C.E. Peck, Oyebola O. Oyesola, Josca E. Cortes, Shengli Ding, Huiyu Gong, Karin Allenspach, Michael J. Shanahan, Kieran Koch-Laskowski, Breanna Sheahan, Mandy Biraud, Steven J. McElroy, Jonathan P. Mochel, Praveen Sethupathy, Yu-Han Hung, Jakob von Moltke
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
MicroRNA-mediated regulation is critical for the proper development and function of the small intestinal (SI) epithelium. However, it is not known which microRNAs are expressed in each of the cell types of the SI epithelium. To bridge this important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9bd0f58b3b3ea78fe704e27c63d0d47
https://europepmc.org/articles/PMC8887887/
https://europepmc.org/articles/PMC8887887/
Autor:
Katherine Harcourt, Michael R. West, Thomas T. MacDonald, Lurdes Rodrigues-Duarte, Anna Vossenkämper, Keith P. Ray, Ray Chai, Luana Maggiore, Marion F. Cubitt, Timothy M. Carlton, Simon Clare, J. Scott Crowe, Kevin J. Roberts
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Anti-TNFα and anti-IL-23 antibodies are highly effective therapies for Crohn’s disease or ulcerative colitis in a proportion of patients. V56B2 is a novel bispecific domain antibody in which a llama-derived IL-23p19-specific domain antibody, human
Publikováno v:
bioRxiv
Journal of Virology
Journal of Virology
Targeting host factors is a promising strategy to develop broad-spectrum antiviral drugs. Drugs targeting anti-apoptotic Bcl-2 family proteins that were originally developed as tumor suppressors have been reported to inhibit multiplication of differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ef8650c293b6092461a4ce20819a60
https://europepmc.org/articles/PMC8382120/
https://europepmc.org/articles/PMC8382120/
Autor:
Karthik Mouli, Elena Kamynina, Seth A. Peng, Becca A. Flitter, Bridget M. Mooney, Pamela Campioli, Rebecca L. Cubitt, Michael J. Shanahan, Isabella Rauch, Simon P. Früh, Oyebola O. Oyesola, James D. Lord, Marija S. Nadjsombati, Praveen Sethupathy, Madeline J Churchill, Jakob von Moltke, Shuchi Smita, Karsten Gronert, Macy K. Matheson, Duc H. Pham, Matt Kanke, Jordan L. Cahoon, Elia D. Tait Wojno, Pavithra Sundaravaradan, John W. McGinty, Lauren M. Webb
Publikováno v:
The Journal of Experimental Medicine
Type 2 cytokines promote epithelial changes that help to expel worms during intestinal helminth infection. Oyesola et al. show that prostaglandin D2 and its receptor CRTH2 are novel negative regulators of this response, dampening the Type 2 cytokine
Autor:
Timothy Schappe, Miriam T. Jacobs, Todd A. Fehniger, Melissa M. Berrien-Elliott, Alice Zhou, Keenan J. Robbins, Bradley A. Krasnick, Celia C. Cubitt, Nancy D. Marin, Lynne Marsala, Christopher Wetzel, Michelle Becker-Hapak, Jennifer A. Foltz, Pamela Wong, Ryan C. Fields, Leah Conant, David A. Russler-Germain, Jennifer Tran, Mark P. Foster, Simon P. Goedegebuure
Publikováno v:
Clin Cancer Res
Purpose:Treatment of advanced melanoma is a clinical challenge. Natural killer (NK) cells are a promising cellular therapy for T cell–refractory cancers, but are frequently deficient or dysfunctional in patients with melanoma. Thus, new strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8496c86b6f83a236ec5ad44c4240a323
https://europepmc.org/articles/PMC8416927/
https://europepmc.org/articles/PMC8416927/
Autor:
Ravi K. Patel, Charles G. Danko, Lauren M. Webb, Simon P. Früh, Tajie H. Harris, Jennifer K. Grenier, Oyebola O. Oyesola, Rebecca L. Cubitt, Andrew Grimson, Katherine M. Still, Elena Kamynina, Elia D. Tait Wojno, Seth A. Peng
Publikováno v:
The Journal of Experimental Medicine
Basophils promote type 2 inflammation that mediates worm clearance during murine infection with the gastrointestinal helminth parasite Trichuris muris. Webb et al. show for the first time that basophil–intrinsic Notch signaling is required for baso
Autor:
William S. Dalton, Juan A Gomez, Jongphil Kim, Taiga Nishihori, Joel G. Turner, Yan Cui, Daniel M. Sullivan, Jana L. Dawson, Alexis Bauer, Christopher L. Cubitt
Publikováno v:
Cancer Res
High-dose chemotherapy with melphalan followed by autologous transplantation is a first-line treatment for multiple myeloma. Here, we present preclinical evidence that this treatment may be significantly improved by the addition of exportin 1 inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983f4b8a19e451cb06ad52fdee4241f9
https://europepmc.org/articles/PMC7718436/
https://europepmc.org/articles/PMC7718436/
Autor:
Daniel Y. Zhang, Sarshan R. Pather, Hongjun Song, Samuel Zheng Hao Wong, Fadi Jacob, Guo Li Ming, Beatrice Cubitt, Catherine Z. Chen, Anne G. Bang, Juan Carlos de la Torre, Wei Zheng, Feng Zhang, Wei-Kai Huang, Wenqiang Fan, Haowen Zhou, Manisha Pradhan, Miao Xu
Publikováno v:
Cell Stem Cell
bioRxiv
bioRxiv
Neurological complications are common in patients with COVID-19. While SARS-CoV-2, the causal pathogen of COVID-19, has been detected in some patient brains, its ability to infect brain cells and impact their function are not well understood. Here we