Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Chunyang Gu"'
Publikováno v:
Viruses; Volume 14; Issue 8; Pages: 1629
Several small animal models, including mice, Syrian hamsters, guinea pigs, and ferrets are used to study the pathogenicity, transmissibility, and antigenicity of seasonal and pandemic influenza viruses. Moreover, animal models are essential for vacci
Autor:
Jayeeta Dutta, Shinya Yamada, Sara Takasaki, Harm van Bakel, Kohei Shimizu, Kosuke Takada, Masaki Imai, Shiho Chiba, Zenab Khan, Tiago J. S. Lopes, Gongxun Zhong, Yoshihiro Kawaoka, Tokiko Watanabe, Chunyang Gu, Yuko Sakai-Tagawa, Shufang Fan, Divya Kriti, Chiharu Kawakami
Publikováno v:
Nature Microbiology. 4:1268-1273
Here, we developed hCK, a Madin-Darby canine kidney (MDCK) cell line that expresses high levels of human influenza virus receptors and low levels of avian virus receptors. hCK cells supported human A/H3N2 influenza virus isolation and growth much mor
Autor:
Hualan Chen, Xianying Zeng, Liling Liu, Yoshihiro Kawaoka, Yanbing Li, Yangming Song, Dongming Zhao, Chunyang Gu
Publikováno v:
Science China Life Sciences. 62:76-83
Antigenic drift forces us to frequently update influenza vaccines; however, the genetic basis for antigenic variation remains largely unknown. In this study, we used clade 7.2 H5 viruses as models to explore the molecular determinants of influenza vi
Autor:
Xuyong Li, Jianzhong Shi, Jing Guo, Guohua Deng, Qianyi Zhang, Jinliang Wang, Xijun He, Kaicheng Wang, Jiming Chen, Yuanyuan Li, Jun Fan, Huiui Kong, Chunyang Gu, Yuantao Guan, Yasuo Suzuki, Yoshihiro Kawaoka, Liling Liu, Yongping Jiang, Guobin Tian, Yanbing Li, Zhigao Bu, Hualan Chen
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008284 (2020)
PLoS Pathogens
PLoS Pathogens
H9N2 subtype influenza viruses have been detected in different species of wild birds and domestic poultry in many countries for several decades. Because these viruses are of low pathogenicity in poultry, their eradication is not a priority for animal
Autor:
Jianzhong Shi, Guohua Deng, Zeng Wang, Yuntao Guan, Huihui Kong, Jingfei Wang, Shujie Ma, Chunyang Gu, Hualan Chen
Publikováno v:
Journal of Virology
Efficient transmission is a prerequisite for a novel influenza virus to cause an influenza pandemic; however, the genetic determinants of influenza virus transmission remain poorly understood. H7N9 influenza viruses, which emerged in 2013 in China, h
Autor:
Huihui Kong, Jianzhong Shi, Guohua Deng, Xianying Zeng, Yasuo Suzuki, Yanbing Li, Guobin Tian, Hualan Chen, Pucheng Chen, Chunyang Gu, Yongping Jiang, Liling Liu
Publikováno v:
Journal of Virology
The H5N1 avian influenza viruses emerged in Southeast Asia in the late 20th century and have evolved into multiple phylogenetic clades based on their hemagglutinin (HA)-encoding genes. The clade 7.2 viruses were first detected in chickens in northern
Autor:
Jianzhong Shi, Chunyang Gu, Yuntao Guan, Guohua Deng, Yanbing Li, Libin Liang, Yasuo Suzuki, Yongping Jiang, Hualan Chen, Chengjun Li, Shuai Wang, Qianyi Zhang, Huihui Kong, Guobin Tian, Liling Liu
Publikováno v:
Journal of Virology
H4 avian influenza virus (AIV) is one of the most prevalent influenza virus subtypes in the world. However, whether H4 AIVs pose a threat to public health remains largely unclear. Here, we analyzed the phylogenetic relationships, receptor binding pro
Autor:
Huihui Kong, Xijun He, Qianyi Zhang, Hualan Chen, Huanliang Yang, Hong Zhou, Yoshihiro Kawaoka, Hang Yin, Chengjun Li, Shasha Meng, Yu Sun, Liping Liu, Chuanling Qiao, Yan Chen, Chunyang Gu, Zhigao Bu
Publikováno v:
Proceedings of the National Academy of Sciences. 113:392-397
Pigs are important intermediate hosts for generating novel influenza viruses. The Eurasian avian-like H1N1 (EAH1N1) swine influenza viruses (SIVs) have circulated in pigs since 1979, and human cases associated with EAH1N1 SIVs have been reported in s
Autor:
Zhigao Bu, Jun Fan, Jianzhong Shi, Xiurong Wang, Guojun Wang, Jing Guo, Qimeng Li, Hualan Chen, Yuanyuan Li, Huanliang Yang, Xijun He, Yuntao Guan, Jinxiong Liu, Huihui Kong, Jinliang Wang, Guohua Deng, Lizheng Guan, Qianyi Zhang, Wenhui Li, Chengjun Li, Li Jiang, Guobin Tian, Pucheng Chen, Xiaoguang Xin, Yan Chen, Chunyang Gu, Yongping Jiang, Chuanling Qiao, Libin Liang, Xianying Zeng, Xuyong Li, Liling Liu
Publikováno v:
Science. 341:410-414
H7N9 Adaptation Puzzling and alarming reports of an outbreak in early 2013 of human infections by a low-pathogenicity avian influenza virus has rocked the poultry industry in central eastern China and brought fears of initiating a human pandemic. Ove
Autor:
Jianzhong Shi, Jinxiong Liu, Shujie Ma, Huihui Kong, Hualan Chen, Yongping Jiang, Qianyi Zhang, Chunyang Gu, Yuntao Guan, Pucheng Chen, Guohua Deng
Publikováno v:
Scientific Reports
The continued spread of the newly emerged H7N9 viruses among poultry in China, together with the emergence of drug-resistant variants and the possibility of human-to-human transmission, has spurred attempts to develop an effective vaccine. An MF59-ad