Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Carol A. de la Motte"'
Autor:
Daniel L. Worthley, Rocio Lopez, Gail West, Guntram A. Grassl, Genevieve Doyon, Shardul Bhilocha, Florian Rieder, Dina Dejanovic, Satya Kurada, Ren Mao, Sara El Ouali, Claudio Fiocchi, Shuai Zhao, Paul L. Fox, Anja Schirbel, Michael Cruise, Peng Yao, Tammy Sadler, Carol A. de la Motte
Publikováno v:
Mucosal immunology
Background: Intestinal fibrosis leading to strictures remains a significant clinical problem in inflammatory bowel diseases (IBD). The role of bacterial components in activating intestinal mesenchymal cells and driving fibrogenesis is largely unexplo
Autor:
Jeanette Wat, Megan R. McMullen, Paramananda Saikia, Damien A Bellos, Laura E. Nagy, Carol A. de la Motte, Dhara Sharma
Publikováno v:
Alcohol Clin Exp Res
Background Specific-sized species of the carbohydrate hyaluronan elicit a variety of cellular responses mediating tissue integrity and repair, as well as regulating inflammatory responses. Orally provided hyaluronan with an average molecular weight o
Autor:
Aviv Hargil, Carol A. de la Motte, Nadine Nagy, Stephen P. Evanko, Sheri M. Krams, Irina Gurevich, Hedwich F. Kuipers, Thomas N. Wight, Quynh-Lam Tran, Robert B. Vernon, Paul L. Bollyky, Amrit Ramesh, Bryan J. Xie, Graham L. Barlow, Naomi L. Haddock, Everett Meyer, Xiangyue Zhang, Koshika Yadava, Colin A. Lester, John A. Gebe, Gernot Kaber, Xi Wang, Payton L. Marshall, Andrey V. Malkovskiy, Miles H. Linde, Hunter A. Martinez, Christiaan R. de Vries, Edgar G. Engleman
Publikováno v:
Matrix Biol
A coat of pericellular hyaluronan surrounds mature dendritic cells (DC) and contributes to cell-cell interactions. We asked whether 4-methylumbelliferone (4MU), an oral inhibitor of HA synthesis, could inhibit antigen presentation. We find that 4MU t
Autor:
Carol A. de la Motte, Yeojung Kim
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
Hyaluronan (HA) is best known as an abundantly present extracellular matrix component found throughout the body of all vertebrates, including humans. Recent evidence, however, has demonstrated benefits of providing HA exogenously as a therapeutic mod
Autor:
Zhongxin Yu, Hala Chaaban, Kathryn Burge, Aarthi Gunasekaran, Wei Zheng, Sean P. Kessler, Carol A. de la Motte, Jeffrey Eckert
Publikováno v:
Pediatr Res
Autor:
Aaron C. Petrey, Laura E. Nagy, Carol A. de la Motte, Yeojung Kim, Greeshma Ray, Claudio Fiocchi, Christine McDonald, Gail West, Michelle Suzanne Longworth, Sean P. Kessler
Publikováno v:
Matrix Biology. 66:93-109
Tight junction proteins are critical in maintaining homeostatic intestinal permeability. Multiple intestinal inflammatory diseases are correlated with reduced expression of tight junction proteins. We have recently reported that oral treatment of mic
Autor:
Aaron C. Petrey, Sean P. Kessler, Christine McDonald, Kourtney P. Nickerson, Dana R. Obery, Carol A. de la Motte
Publikováno v:
Journal of Histochemistry & Cytochemistry. 66:273-287
Intestinal epithelium plays a critical role in host defense against orally acquired pathogens. Dysregulation of this protective barrier is a primary driver of inflammatory bowel diseases (Crohn’s and ulcerative colitis) and also infant gastrointest
Autor:
Christine McDonald, Dana R. Obery, Craig R. Homer, Yeojung Kim, Sean P. Kessler, Carol A. de la Motte
Publikováno v:
Matrix Biology. 62:28-39
Maintaining a healthy intestinal barrier, the primary physical barrier between intestinal microbiota and the underlying lamina propria, is critical for optimal health. Epithelial integrity is essential for the prevention of the entrance of luminal co
Publikováno v:
American Journal of Pathology. 186(9):2390-2403
Hyaluronan is the predominant glycosaminoglycan component of the extracellular matrix with an emerging role in hematopoiesis. Modulation of hyaluronan polymer size is responsible for its control over cellular functions, and the balance of hyaluronan
Autor:
Zhongxin Yu, Aarthi Gunasekaran, Carol A. de la Motte, Sean P. Kessler, Wei Zheng, Hala Chaaban, Kathryn Burge, Jeffrey Eckert
Publikováno v:
Pediatric research
Background Disruption of tight junctions (TJs) predisposes to bacterial translocation, intestinal inflammation, and necrotizing enterocolitis (NEC). Previously, studies showed that hyaluronan (HA), a glycosaminoglycan in human milk, maintains intesti