Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Bruce A. Smith"'
Publikováno v:
Progress in molecular biology and translational science. 189(1)
Dogs are remarkable, adaptable, and dependable creatures that have evolved alongside humans while contributing tremendously to our survival. Our canine companions share many similarities to human disease, particularly cancer. With the advancement of
Autor:
Rebecca L. Nance, Sara J. Cooper, Dmytro Starenki, Xu Wang, Brad Matz, Stephanie Lindley, Annette N. Smith, Ashley A. Smith, Noelle Bergman, Maninder Sandey, Jey Koehler, Payal Agarwal, Bruce F. Smith
Publikováno v:
Genes; Volume 13; Issue 4; Pages: 680
Despite significant advances in cancer diagnosis and treatment, osteosarcoma (OSA), an aggressive primary bone tumor, has eluded attempts at improving patient survival for many decades. The difficulty in managing OSA lies in its extreme genetic compl
Autor:
Bruce F. Smith, Scott D. Fitzgerald, Chady H. Hakim, Dongsheng Duan, Scott W. Korte, Jessica S. Fortin, N. Nora Yang, Gayle C. Johnson
Publikováno v:
Veterinary Medicine and Science
Veterinary Medicine and Science, Vol 7, Iss 3, Pp 654-659 (2021)
Veterinary Medicine and Science, Vol 7, Iss 3, Pp 654-659 (2021)
The University of Missouri (MU) has established a colony of dystrophin‐deficient dogs with a mixed breed background to mirror the variable pathologic effects of dystrophinopathies between persons of a given kindred to further the understanding of t
Autor:
Jonathan Marable, Bruce F. Smith, Damien Ruiz, Ritankar Bhattacharya, Robert J. Pantazes, Amarjit Mishra, Payal Agarwal, Anil Kumar Jaiswal, Deepa Bedi, Maninder Sandey, Amol Suryawanshi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Background Cancer is the leading cause of death in the geriatric dog population. Currently, the use of immune checkpoint inhibitors (ICIs) such as anti-CTLA4 antibodies has markedly improved the prognosis of several cancers in their advanced stages.
Publikováno v:
Neuromuscular Disorders. 28:927-937
In humans, dystrophin mutations cause the X-linked recessive disorder known as Duchenne muscular dystrophy (DMD). These mutations result in skeletal and cardiac muscle damage with mortality increasingly associated with cardiomyopathy. We have identif
Autor:
Abdul Mohin, Sajib, Payal, Agarwal, Daniel J, Patton, Rebecca L, Nance, Natalie A, Stahr, Will P, Kretzschmar, Maninder, Sandey, Bruce F, Smith
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 101(12)
Genetically modified oncolytic adenoviruses have been proposed as a vehicle for cancer therapy. However, several concerns, such as toxicity to normal cells and organs, lack of suitable cell surface receptors to allow viral entry to the desired cell t
Autor:
Payal Agarwal, Bruce F. Smith, Jey W. Koehler, Abdul Mohin Sajib, Rebecca L Nance, Dmytro Starenki, Maninder Sandey
Publikováno v:
BioTechniques. 68(6)
Extracting sufficient quantity and quality RNA from bone is essential for downstream application, such as transcriptomic sequencing, to evaluate gene expression. Isolation of RNA from bone presents a unique challenge owing to the hypocellular, brittl
Autor:
E. Gisela Martinez-Romero, Annette N. Smith, Farruk M. Lutful Kabir, Allison E. Church Bird, Patricia DeInnocentes, Bruce F. Smith, R. Curtis Bird
Publikováno v:
Journal of Veterinary Science
Breast cancer is among the most common malignancies affecting women and reproductively intact female dogs, resulting in death from metastatic disease if not treated effectively. To better manage the disease progression, canine mammary tumor (CMT) cel
Autor:
Jenna Bloemer, Ahmad Alhowail, Nathaniel Johnson, Manal Ali Buabeid, Lauren N. Woodie, Vishnu Suppiramaniam, Matthew Eggert, Alyssa Broadwater, Muralikrishnan Dhanasekaran, Subhrajit Bhattacharya, Mohammed Majrashi, Dwipayan Bhattacharya, Bruce F. Smith, Zhang Yongli, Priyanka D. Pinky, Robert D. Arnold
Publikováno v:
Toxicology mechanisms and methods. 29(6)
Cognitive deficits are commonly reported by patients following treatment with chemotherapeutic agents. Anthracycline-containing chemotherapy regimens are associated with cognitive impairment and reductions in neuronal connectivity in cancer survivors
Autor:
Payal Agarwal, Bradley Schuler, Bruce F. Smith, Abdul Mohin Sajib, Maninder Sandey, Samantha Morici
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 11, p e0240807 (2020)
PLoS ONE, Vol 15, Iss 11, p e0240807 (2020)
Gene therapy is a promising treatment option for cancer. However, its utility may be limited due to expression in off-target cells. Cancer-specific promoters such as telomerase reverse transcriptase (TERT), survivin, and chemokine receptor 4 (CXCR4)