Zobrazeno 1 - 10
of 271
pro vyhledávání: '"Bo Wen"'
Publikováno v:
BioMed Research International. 2022:1-17
Objective. To investigate the main pharmacological basis and mechanism of action of Gujiansan in the treatment of steroid-induced avascular necrosis of the femoral head (SANFH). Methods. The active constituents and targets of Gujiansan were screened
Autor:
Meng‐min Zhu, Bo‐wen Niu, Ling‐ling Liu, Hua Yang, Bo‐yin Qin, Xiu‐hua Peng, Li‐xiang Chen, Yang Liu, Chao Wang, Xiao‐nan Ren, Chun‐hua Xu, Xiao‐hui Zhou, Feng Li
Publikováno v:
Animal Models and Experimental Medicine. 5:350-361
There are remarkable genetic differences between animal major histocompatibility complex (MHC) systems and the human leukocyte antigen (HLA) system. HLA transgenic humanized mouse model systems offer a much better method to study the HLA-A-related pr
Publikováno v:
Biochemical and Biophysical Research Communications. 598:26-31
Globins are heme proteins such as hemoglobin (Hb), myoglobin (Mb) and neuroglobin (Ngb), playing important roles in biological system. In addition to normal functions, zebrafish Ngb was able to penetrate cell membranes, whereas less was known for oth
Publikováno v:
Environmental Entomology. 51:521-527
The community structure and diversity of hymenopteran parasitoids of the agromyzid leafminer Chromatomyia horticola (Diptera: Agromyzidae) were studied in agricultural, urban, and natural habitats in Changchun, Northeast China. In agricultural habita
Publikováno v:
American Journal of Physiology-Cell Physiology. 322:C164-C176
Myocardial infarction (MI)-induced heart failure (HF) is commonly accompanied with profound effects on skeletal muscle. With the process of MI-induced HF, perturbations in skeletal muscle contribute to muscle atrophy. Exercise is viewed as a feasible
Autor:
Hsi-Chien Huang, Yun-Chieh Sung, Chung-Pin Li, Dehui Wan, Po-Han Chao, Yu-Ting Tseng, Bo-Wen Liao, Hui-Teng Cheng, Fu-Fei Hsu, Chieh-Cheng Huang, Yi-Ting Chen, Yu-Hui Liao, Hsin Tzu Hsieh, Yu-Chuan Shih, I-Ju Liu, Han-Chung Wu, Tsai-Te Lu, Jane Wang, Yunching Chen
Publikováno v:
Gut. 71:1843-1855
ObjectiveStromal barriers, such as the abundant desmoplastic stroma that is characteristic of pancreatic ductal adenocarcinoma (PDAC), can block the delivery and decrease the tumour-penetrating ability of therapeutics such as tumour necrosis factor-r
Autor:
Bo Wen, Shaomeng Wang, Duxin Sun, Miao He, Paul D. Kirchhoff, Weiguo Xiang, Chong Qin, Xin Han, Donna McEachern, Lu Wang, Hoda Metwally, Aleksas Matvekas, Lijie Zhao, Yu Wang, Bukeyan Miao
Publikováno v:
J Med Chem
We report herein the discovery of exceptionally potent and orally bioavailable PROTAC AR degraders with ARD-2585 being the most promising compound. ARD-2585 achieves DC(50) values of ≤0.1 nM in the VCaP cell line with AR gene amplification and in t
Autor:
Xin Han, Aleksas Matvekas, Bukeyan Miao, Weiguo Xiang, Bo Wen, Lijie Zhao, Chong Qin, Yu Wang, Lu Wang, Hoda Metwally, Donna McEachern, Shaomeng Wang, Duxin Sun
Publikováno v:
J Med Chem
Proteolysis targeting chimera (PROTAC) small-molecule degraders have emerged as a promising new type of therapeutic agents, but the design of PROTAC degraders with excellent oral pharmacokinetics is a major challenge. In this study, we present our st
Autor:
Yuefeng Sun, Fan Yang, Weijun Cao, Huisheng Liu, Jingyu Wang, Haixue Zheng, Zixiang Zhu, Bo Wen, Shuying Chen
Publikováno v:
Journal of Proteome Research. 20:4113-4130
Peste des petits ruminants virus (PPRV) infection causes considerable innate immunosuppression in its host, which promotes viral replication. However, how the host rescues the innate immune response to counteract this immunosuppression during viral r
Autor:
Mengmeng Wang, Fen Li, Xiangyu Xi, Peng-Bo Wen, Xin-Yi Shi, Qing-Hua Liu, Xue-Song Xiong, Xiao Zhang, Eng Guan Chua, Liang Wang, Jia-Wei Tang, Zhanzhong Liu, Zhao Liu
Publikováno v:
BMC Complementary Medicine and Therapies, Vol 21, Iss 1, Pp 1-15 (2021)
BMC Complementary Medicine and Therapies
BMC Complementary Medicine and Therapies
Background Mulberry leaf as a traditional Chinese medicine is able to treat obesity, diabetes, and dyslipidemia. It is well known that diabetes leads to intestinal microbiota dysbiosis. It is also recently discovered that liver glycogen structure is