Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Antrix Jain"'
Autor:
Aude Angelini, Jesus Ortiz-Urbina, JoAnn Trial, Anilkumar K. Reddy, Anna Malovannaya, Antrix Jain, Mark L. Entman, George E. Taffet, Katarzyna A. Cieslik
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(2)
The incidence of diastolic dysfunction increases with age in both humans and mice. This is characterized by increased passive stiffness and slower relaxation of the left ventricle. The stiffness arises at least partially from progressively increased
Autor:
Alexandria M. Doerfler, Jun Han, Kelsey E. Jarrett, Li Tang, Antrix Jain, Alexander Saltzman, Marco De Giorgi, Marcel Chuecos, Ayrea E. Hurley, Ang Li, Pauline Morand, Claudia Ayala, David R. Goodlett, Anna Malovannaya, James F. Martin, Thomas Q. de Aguiar Vallim, Noah Shroyer, William R. Lagor
Publikováno v:
Arterioscler Thromb Vasc Biol
Background: The intestine occupies the critical interface between cholesterol absorption and excretion. Surprisingly little is known about the role of de novo cholesterol synthesis in this organ, and its relationship to whole body cholesterol homeost
Autor:
Debosmita Sardar, Hsiao-Chi Chen, Amanda Reyes, Srinidhi Varadharajan, Antrix Jain, Carrie Mohila, Rachel Curry, Brittney Lozzi, Kavitha Rajendran, Alexis Cervantes, Kwanha Yu, Ali Jalali, Ganesh Rao, Stephen C. Mack, Benjamin Deneen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(29)
Epigenetic dysregulation is a universal feature of cancer that results in altered patterns of gene expression that drive malignancy. Brain tumors exhibit subtype-specific epigenetic alterations; however, the molecular mechanisms responsible for these
Autor:
Hon-Chiu Eastwood Leung, Gianfranco Matrone, Antrix Jain, Martin A. Denvir, John P. Cooke, Julie Rodor, Cristian Coarfa, Sung Yun Jung, Jong Min Choi, Kimal Rajapakshe, Andy Baker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Matrone, G, Jung, S Y, Choi, J M, Jain, A, Eastwood Leung, H-C, Rajapakshe, K, Coarfa, C, Rodor, J, Denvir, M A, Baker, A H & Cooke, J P 2021, ' Nuclear S-nitrosylation impacts tissue regeneration in zebrafish ', Nature Communications . https://doi.org/10.1038/s41467-021-26621-0
Nature Communications
Matrone, G, Jung, S Y, Choi, J M, Jain, A, Eastwood Leung, H-C, Rajapakshe, K, Coarfa, C, Rodor, J, Denvir, M A, Baker, A H & Cooke, J P 2021, ' Nuclear S-nitrosylation impacts tissue regeneration in zebrafish ', Nature Communications . https://doi.org/10.1038/s41467-021-26621-0
Despite the importance of nitric oxide signaling in multiple biological processes, its role in tissue regeneration remains largely unexplored. Here, we provide evidence that inducible nitric oxide synthase (iNos) translocates to the nucleus during ze
Autor:
Yu Chen Du, Antrix Jain, Sung Yun Jung, Xiao-Nan Li, Xiang Chen, John Hicks, Justin M M Cates, Tsz-Kwong Man
Publikováno v:
Molecular Oncology, Vol 14, Iss 4, Pp 846-864 (2020)
Molecular Oncology
Molecular Oncology
The development of pulmonary metastasis is the leading cause of death in osteosarcoma (OS), which is the most common malignant bone tumor in children. We have previously reported that the tumor suppressor p27 (KIP1, CDKN1B) is frequently mislocalized
Autor:
Antrix Jain, Nick Matinyan, Mansi S. Karkhanis, Koen J. T. Venken, Yezabel Gonzalez, Anna Malovannaya, Alexander B. Saltzman, Herman A. Dierick, Alejandro Sarrion-Perdigones
Publikováno v:
Cell Reports, Vol 36, Iss 11, Pp 109700-(2021)
Cell reports
Cell reports
SUMMARY The power of Drosophila melanogaster as a model system relies on tractable germline genetic manipulations. Despite Drosophila’s expansive genetics toolbox, such manipulations are still accomplished one change at a time and depend predominan
Autor:
Jun Qin, Shao Cong Sun, Haiyan S. Li, Jin Young Yang, Stephanie S. Watowich, Xuhong Cheng, Xiaofei Zhou, Daniel Lin, Jian-hong Shi, Lingyun Zhang, Yanchuan Li, Zuliang Jie, Meidi Gu, Xiaoping Xie, Antrix Jain, Sung Yun Jung
Publikováno v:
Cell Res
NF-κB, a family of transcription factors regulating diverse biological processes including immune responses, is activated by canonical and noncanonical pathways based on degradation of IκBα and processing of the IκB-like protein p100, respectivel
Autor:
Richard N. Sifers, Carolyn J. Adamski, Antrix Jain, Kaifang Pang, J. Lloyd Holder, Sung Yun Jung, Huda Y. Zoghbi, Zhandong Liu, Li Wang, Vitaliy V. Bondar, Evelyn Craigen, John R. Collette, Kihoon Han
Publikováno v:
Molecular psychiatry
Neurons are sensitive to changes in the dosage of many genes, especially those regulating synaptic functions. Haploinsufficiency of SHANK3 causes Phelan-McDermid syndrome and autism, whereas duplication of the same gene leads to SHANK3 duplication sy
Autor:
Sung Yun Jung, Matthew J. Ellis, Purba Singh, Hamssika Chandrasekaran, Antrix Jain, Anna Malovannaya, Doug W. Chan, Lacey E. Dobrolecki, Jong M. Choi, Alexander B. Saltzman, Bhoomi Bhatt, Mei Leng, Michael T. Lewis
Publikováno v:
Molecular & Cellular Proteomics. 17:2270-2283
In quantitative mass spectrometry, the method by which peptides are grouped into proteins can have dramatic effects on downstream analyses. Here we describe gpGrouper, an inference and quantitation algorithm that offers an alternative method for assi
Autor:
Axel Loredo, Yuda Chen, Chenfei Yu, Aviva Gordon, Juan Tang, Sung Yun Jung, Antrix Jain, Han Xiao
Publikováno v:
Bioconjugate Chemistry. 29:3522-3526
Site-specific antibody conjugates with a well-defined structure and superb therapeutic index are of great interest for basic research, disease diagnostics, and therapy. Here, we develop a novel proximity-induced antibody conjugation strategy enabling