Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Amy Belton"'
Autor:
Michael Koo, James Turkson, David L. Huso, Tait Huso, Patrick T. Gunning, Lingling Xian, Guosheng Liu, Brent D. G. Page, Amy Belton, Li Z. Luo, Linda M.S. Resar
Publikováno v:
Leukemia & Lymphoma. 57:2681-2684
Despite dramatic improvements in treatment and survival, acute lymphoid malignancies remain the leading cause of death in children with cancer and a highly lethal malignancy in adults.[1] Acute lym...
Autor:
Leslie Cope, Linda M.S. Resar, Wenyong Kuang, Lingling Xian, David L. Huso, Andrew J. Ewald, Stefania Senger, Amy Belton, Tait Huso, Alessio Fasano, Dan Georgess, Yu Ting Chang, Xiaoyan Zhang, Qihua Gu
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. Prior studies showed that Hmga1 drives hyperproliferation, aberrant crypt formation and p
Autor:
Leslie Cope, Tait Huso, Andrew Schuldenfrei, Linda M.S. Resar, Nathaniel R. Campbell, Collins Karikari, David L. Huso, Francescopaolo Di Cello, Dwella M. Nelson, Amy Belton, Anirban Maitra, Abimbola Aderinto, Shamayra S. Smail, Sandeep N. Shah, Joelle Hillion
Publikováno v:
Pancreatology. 12:372-379
Although pancreatic cancer is a common, highly lethal malignancy, the molecular events that enable precursor lesions to become invasive carcinoma remain unclear. We previously reported that the high-mobility group A1 (HMGA1) protein is overexpressed
Publikováno v:
Genome. 49:746-751
Two deletions, Df(2R)Sod2-11 and Df(2R)Sod2-332, are recovered that encompass the manganese superoxide dismutase (MnSOD) gene or a null mutant referred to as SOD2n283 in Drosophila. Molecular analysis has revealed that the Df(2R)Sod2-332 deletion com
Publikováno v:
Genetics. 165:2295-2299
A null mutation for the Sod2 gene, Sod2n283, was obtained in Drosophila melanogaster. Homozygous Sod2 null (Sodn283/Sodn283) adult flies survive up to 24 hr following eclosion, a phenotype reminiscent of mice, where Sod2–/– progeny suffer neonata
Autor:
C. Conover Talbot, Francescopaolo Di Cello, Jeanne Kowalski, Sandeep N. Shah, Linda M.S. Resar, Amy Belton, Weijie Poh, David L. Huso, Hua Ling Tsai, Tait Huso, Andrew Schuldenfrei
Publikováno v:
BMC Genomics, Vol 12, Iss 1, p 549 (2011)
BMC Genomics
BMC Genomics
Background Although the high mobility group A1 (HMGA1) gene is widely overexpressed in diverse cancers and portends a poor prognosis in some tumors, the molecular mechanisms that mediate its role in transformation have remained elusive. HMGA1 functio
Publikováno v:
Fly. 5(1)
Definitive evidence on the impact of MnSOD/SOD2-deficiency and the consequent effects of high flux of mitochondrial reactive oxygen species (ROS) on pre-natal/pre-adult development has yet to be reported for either Drosophila or mice. Here we report
Autor:
Linda M.S. Resar, Francescopaolo Di Cello, Peter D. Aplan, Takita Felder Sumter, James Turkson, Joelle Hillion, Ying Wei Lin, Amy Belton, Zhaohui Ye, Soumya Jaganathan, Richard Jove, Kelsey J. Wertzler, Jeanne Kowalski, Ray Reeves, Surajit Dhara, Mita Mukherjee, Ossama Elbahlouh, Linzhao Cheng, Raka Bhattacharya
Although HMGA1 (high-mobility group A1; formerly HMG-I/Y) is an oncogene that is widely overexpressed in aggressive cancers, the molecular mechanisms underlying transformation by HMGA1 are only beginning to emerge. HMGA1 encodes the HMGA1a and HMGA1b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562f5898023eef739b597aecdd1d67ec
https://europepmc.org/articles/PMC2913892/
https://europepmc.org/articles/PMC2913892/
Publikováno v:
Mechanisms of ageing and development. 128(11-12)
Manganese superoxide dismutase (MnSOD or SOD2) is a key mitochondrial enzymatic antioxidant. Arguably the most striking phenotype associated with complete loss of SOD2 in flies and mice is shortened life span. To further explore the role of SOD2 in p