Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alfredo Castello"'
Autor:
Connor G. G. Bamford, Milagros Rodriguez Collados, Alfredo Castello, Srikeerthana Kuchi, David Robertson, Nardus Mollentze, Sam J. Wilson, Joseph Busby, Arthur Wickenhagen, Douglas G. Stewart, Richard J. Orton, Siddharth Bakshi, Quan Gu, Elena Sugrue, Matthew L. Turnbull, Daniel G. Streicker, Massimo Palmarini, Suzannah J. Rihn, Andrew Shaw, Ana Filipe da Silva, Paul C. D. Johnson, Katherine Smollett
Publikováno v:
PLoS Biology
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
PLoS Biology, Vol 19, Iss 9, p e3001352 (2021)
Antiviral defenses can sense viral RNAs and mediate their destruction. This presents a challenge for host cells since they must destroy viral RNAs while sparing the host mRNAs that encode antiviral effectors. Here, we show that highly upregulated int
Autor:
Ilan Davis, Peter J. Ratcliffe, Alfredo Castello, William James, Jeffrey Y. Lee, Maria Prange-Barczynska, Marko Noerenberg, Jane A. McKeating, Craig Thompson, Senko Tsukuda, Koichi Watashi, Isobel L.A. Argles, Thomas P. Keeley, Sophie B. Morgan, Peter A C Wing, Samvid Kurlekar, Kuan-Ying A. Huang, Xiaodong Zhuang, Timothy S. C. Hinks, Tammie Bishop, Peter Balfe, Emma J. Hodson, Adam Harding
Publikováno v:
Cell Reports
Cell Reports, Vol 35, Iss 3, Pp 109020-(2021)
Cell Reports, Vol 35, Iss 3, Pp 109020-(2021)
COVID-19, caused by the novel coronavirus SARS-CoV-2, is a global health issue with more than 2 million fatalities to date. Viral replication is shaped by the cellular microenvironment and one important factor to consider is oxygen tension, where hyp
Autor:
Matthias W. Hentze, Rozemarijn Kleinendorst, Asli Adak, Christian Tischer, Magdalena Büscher, Anne-Marie Alleaume, Rastislav Horos, Thomas Schwarzl, Abul K. Tarafder, Elisabeth M. Zielonka, Dmytro Dziuba, Carsten Sachse, Wolfgang Huber, Alfredo Castello
Vault RNAs (vtRNA) are small non-coding RNAs transcribed by RNA polymerase III found in many eukaryotes. Although they have been linked to drug resistance, apoptosis, and viral replication, their molecular functions remain unclear. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdd4e41f974bb6b2e479a80750427ed
https://doi.org/10.1016/j.cell.2019.01.030
https://doi.org/10.1016/j.cell.2019.01.030
Publikováno v:
Open Biology
Open Biology, Vol 10, Iss 12 (2020)
Open Biology, Vol 10, Iss 12 (2020)
The human immunodeficiency virus type 1 (HIV-1) proteome is expressed from alternatively spliced and unspliced genomic RNAs. However, HIV-1 RNAs that are not fully spliced are perceived by the host machinery as defective and are retained in the nucle
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one or multiple globular RNA-binding domains (RBDs) and change the fate or function of the bound RNAs. Several hundred such RBPs have been discovered and investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b673698addb260e76982715b9b2c4fc
https://eprints.gla.ac.uk/219002/1/219002.pdf
https://eprints.gla.ac.uk/219002/1/219002.pdf
A cryptic RNA-binding domain mediates Syncrip recognition and exosomal partitioning of miRNA targets
Autor:
Evangelos Christodoulou, Andres Ramos, Roksana W. Ogrodowicz, André Dallmann, Cecilia Battistelli, Fruzsina Hobor, Ian A. Taylor, Stephen R. Martin, Neil J. Ball, Marco Tripodi, Alfredo Castello, Carla Cicchini
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, 9, Article 831. (2018)
UCL Discovery
Oxford University Research Archive
PubMed Central
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications, 9, Article 831. (2018)
UCL Discovery
Oxford University Research Archive
PubMed Central
Exosomal miRNA transfer is a mechanism for cell–cell communication that is important in the immune response, in the functioning of the nervous system and in cancer. Syncrip/hnRNPQ is a highly conserved RNA-binding protein that mediates the exosomal
Publikováno v:
Wiley Interdisciplinary Reviews: RNA
Wiley Interdisciplinary Reviews. RNA
Wiley Interdisciplinary Reviews. RNA
The crucial participation of cellular RNA‐binding proteins (RBPs) in virtually all steps of virus infection has been known for decades. However, most of the studies characterizing this phenomenon have focused on well‐established RBPs harboring cl
Autor:
Matthias W. Hentze, Alfredo Castello, Elena G. Sánchez, Ana Quintas, Maria L. Nogal, Yolanda Revilla, Daniel Pérez-Núñez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Journal of Virology
instname
Journal of Virology
African swine fever virus (ASFV) infection is characterized by a progressive decrease in cellular protein synthesis with a concomitant increase in viral protein synthesis, though the mechanism by which the virus achieves this is still unknown. Decrea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3eb3b134cf51d88732630badbe19a4c2
https://eprints.gla.ac.uk/221915/1/221915.pdf
https://eprints.gla.ac.uk/221915/1/221915.pdf
Publikováno v:
Current Opinion in Genetics & Development
Cancer development involves the stepwise accumulation of genetic lesions that overcome the normal regulatory pathways that prevent unconstrained cell division and tissue growth. Identification of the genetic changes that cause cancer has long been th
Autor:
Greta, Pintacuda, Guifeng, Wei, Chloë, Roustan, Burcu Anil, Kirmizitas, Nicolae, Solcan, Andrea, Cerase, Alfredo, Castello, Shabaz, Mohammed, Benoît, Moindrot, Tatyana B, Nesterova, Neil, Brockdorff
Publikováno v:
Molecular Cell
Summary The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome silencing induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::84d15b4fdd558acbc3573f5c92e1ef45
http://hdl.handle.net/11568/1121026
http://hdl.handle.net/11568/1121026