Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Alex M. Jaeger"'
Autor:
Alex M. Jaeger, JJ Patten, Olivia Smith, Haley Hauck, Ömer H. Yilmaz, Tyler Jacks, George Eng, Peter M. K. Westcott, Jason M. Schenkel, Coralie Backlund, Ryan Elbashir, Darrell J. Irvine, Zackery A. Ely, Daniel Zhang, Nathan J. Sacks, Mary Clare Beytagh
Publikováno v:
Nature Cancer. 2:1071-1085
Immune evasion is a hallmark of cancer and therapies that restore immune surveillance have proven highly effective in cancers with high tumor mutation burden (TMB) (for example, those with microsatellite instability). Whether low TMB cancers, which a
Autor:
Alex M. Jaeger, Lauren E. Stopfer, Ryuhjin Ahn, Emma A. Sanders, Demi A. Sandel, William A. Freed-Pastor, William M. Rideout, Santiago Naranjo, Tim Fessenden, Kim B. Nguyen, Peter S. Winter, Ryan E. Kohn, Peter M. K. Westcott, Jason M. Schenkel, Sean-Luc Shanahan, Alex K. Shalek, Stefani Spranger, Forest M. White, Tyler Jacks
Publikováno v:
Nature
Immunosurveillance of cancer requires the presentation of peptide antigens on major histocompatibility complex class I (MHC-I)(1,2,3,4,5). Current approaches to profile MHC-I associated peptides, collectively known as the “immunopeptidome”, are l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c592d9e991788f10c2d2d6252e7d29e
https://europepmc.org/articles/PMC9945857/
https://europepmc.org/articles/PMC9945857/
Publikováno v:
Trends in Pharmacological Sciences. 40:986-1005
The ability of cancer cells to cope with stressful conditions is critical for their survival, proliferation, and metastasis. The heat shock transcription factor 1 (HSF1) protects cells from stresses such as chemicals, radiation, and temperature. Thes
Autor:
Jason M. Schenkel, Sara Z. Tavana, Michelle Hillman, Peter M. K. Westcott, Megan L. Burger, Sarah E. Blatt, Tyler Jacks, David Canner, Marta M. Holovatska, Michael Manos, Giorgio Gaglia, Izumi de los Rios Kobara, Aviv Regev, Alex M. Jaeger, Arjun Bhutkar, Sandro Santagata, William L. Hwang, F. Stephen Hodi, Cecily C. Ritch, Amanda M. Cruz, Tamina Kienka, Andrea Garmilla, Alexia L. Barandiaran, Amy Li, Grace E. Crossland
Publikováno v:
Cell
Summary CD8 T cell responses against different tumor neoantigens occur simultaneously, yet little is known about the interplay between responses and its impact on T cell function and tumor control. In mouse lung adenocarcinoma, we found that immunodo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881da5a74e035825ca947128bb7a8b0b
https://europepmc.org/articles/PMC8522630/
https://europepmc.org/articles/PMC8522630/
Autor:
Ryan P. King, Scott B. Snapper, Jeffrey F. Van Humbeck, Constantine N. Tzouanas, Carly G. K. Ziegler, Vanessa Mitsialis, Tyler Jacks, Benjamin E. Mead, Siyi Huang, Miyeko D. Mana, Alex M. Jaeger, Alex K. Shalek, Andrew W. Navia, Ömer H. Yilmaz, Alex S. Genshaft
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Nature Communications
Nature Communications
A cell's phenotype and function are influenced by dynamic interactions with its microenvironment. To examine cellular spatiotemporal activity, we developed SPACECAT-Spatially PhotoActivatable Color Encoded Cell Address Tags-to annotate, track, and is
Autor:
Jason M. Schenkel, Prajan Divakar, Alex M. Jaeger, Ana P. Garcia, Peter M. K. Westcott, Tyler Hether, Zackery A. Ely, Roderick T. Bronson, Laurens J. Lambert, Jason Reeves, William A. Freed-Pastor, Devan Phillips, Vikram Deshpande, Arjun Bhutkar, Kim L. Mercer, Ömer H. Yilmaz, Tyler Jacks, George Eng, Lin Lin, William L. Hwang, Nimisha B. Pattada, Aviv Regev, Toni Delorey, William M. Rideout
Publikováno v:
Cancer Cell
Summary The CD155/TIGIT axis can be co-opted during immune evasion in chronic viral infections and cancer. Pancreatic adenocarcinoma (PDAC) is a highly lethal malignancy, and immune-based strategies to combat this disease have been largely unsuccessf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b53f9987c16263228fdea161ccfed14
https://europepmc.org/articles/PMC8511341/
https://europepmc.org/articles/PMC8511341/
Autor:
Dennis J. Thiele, Daniel W. Neef, Alex M. Jaeger, Rocío Gómez-Pastor, Felix Willmund, Judith Frydman
Publikováno v:
Cell Reports, Vol 9, Iss 3, Pp 955-966 (2014)
SummaryHeat shock transcription factor 1 (HSF1) is an evolutionarily conserved transcription factor that protects cells from protein-misfolding-induced stress and apoptosis. The mechanisms by which cytosolic protein misfolding leads to HSF1 activatio
Publikováno v:
Nature Reviews Drug Discovery. 10:930-944
Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis and prion-based neurodegeneration are associated with the accumulation of misfolded proteins, resulting in neuronal
Publikováno v:
G3: Genes|Genomes|Genetics
Human heat shock transcription factor 1 (HSF1) promotes the expression of stress-responsive genes and is a critical factor for the cellular protective response to proteotoxic and other stresses. In response to stress, HSF1 undergoes a transition from
Publikováno v:
The Journal of biological chemistry. 286(36)
Morphine and other opiates mediate their effects through activation of the μ-opioid receptor (MOR), and regulation of the MOR has been shown to critically affect receptor responsiveness. Activation of the MOR results in receptor phosphorylation, β-