Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Jan Tavernier"'
Autor:
Ralf Jockers, Jan Tavernier, Joris Wauman, Marine Luka, Julie Dam, Vincent Prevot, Tori Lhomme, Tangui Maurice, Lennart Zabeau, Erika Cecon, Anisia J. Silva, Min Min Chen
Publikováno v:
Neuroendocrinology
Neuroendocrinology, 2021, 111 (4), pp.370-387. ⟨10.1159/000508105⟩
Neuroendocrinology, 2021, 111 (4), pp.370-387. ⟨10.1159/000508105⟩
Introduction: Metabolic dysfunction is now recognized as a pivotal component of Alzheimer’s disease (AD), the most common dementia worldwide. However, the precise molecular mechanisms linking metabolic dysfunction to AD remain elusive. Objective: H
Autor:
T.M. Wijesuriya, Jan Tavernier, Rachel Wevrick, Leentje De Ceuninck, Karin Vanessa Carias, Delphine Masschaele, Matthea R. Sanderson
Publikováno v:
Human Molecular Genetics. 26:4215-4230
In Prader-Willi syndrome (PWS), obesity is caused by the disruption of appetite-controlling pathways in the brain. Two PWS candidate genes encode MAGEL2 and necdin, related melanoma antigen proteins that assemble into ubiquitination complexes. Mice l
Autor:
Claude Libert, Marlies Ballegeer, Jan Tavernier, Ioanna Petta, Sam Lievens, Lien Dejager, Karolien De Bosscher
Publikováno v:
Microbiology and Molecular Biology Reviews. 80:495-522
SUMMARYGlucocorticoids (GCs) have been widely used for decades as a first-line treatment for inflammatory and autoimmune diseases. However, their use is often hampered by the onset of adverse effects or resistance. GCs mediate their effects via bindi
Autor:
Ralf Jockers, Lennart Zabeau, Elianne Burg, Jan Tavernier, Jennifer De Geest, Sandra Van Lint, Anisia Silva, Julie Dam, Joris Wauman, Elke Rogge
Publikováno v:
Cellular and molecular life sciences : CMLS. 76(6)
Leptin links body energy stores to high energy demanding processes like reproduction and immunity. Based on leptin's role in autoimmune diseases and cancer, several leptin and leptin receptor (LR) antagonists have been developed, but these intrinsica
Autor:
Jan Tavernier, Dorien Clarisse, Karlien Van Wesemael, Ilse M. Beck, Fritz Offner, Karolien De Bosscher
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 5, p e0197000 (2018)
PLOS ONE
PLoS ONE, Vol 13, Iss 5, p e0197000 (2018)
PLOS ONE
Glucocorticoids (GCs) are a cornerstone in the treatment of lymphoid malignancies such as multiple myeloma (MM) and acute lymphoblastic leukemia (ALL). Yet, prolonged GC use is hampered by deleterious GC-related side effects and the emergence of GC r
Autor:
Riet De Rycke, Kris Gevaert, Viacheslav Mylka, Lode De Cauwer, Claude Libert, Julie Deckers, Wim Vanden Berghe, Jan Tavernier, Francis Impens, Jonathan Thommis, Dariusz Ratman, Karolien De Bosscher
Publikováno v:
Autophagy
AUTOPHAGY
AUTOPHAGY
Glucocorticoids are widely used to treat inflammatory disorders; however, prolonged use of glucocorticoids results in side effects including osteoporosis, diabetes and obesity. Compound A (CpdA), identified as a selective NR3C1/glucocorticoid recepto
Autor:
K. De Bosscher, Jonathan Thommis, Marnik Vuylsteke, Nadia Bougarne, Sofie Desmet, René Houtman, Dariusz Ratman, Jan Tavernier, L. De Cauwer, L. Van de Moortel
Publikováno v:
SCIENTIFIC REPORTS
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
The glucocorticoid receptor (GR) is a transcription factor of which the underlying gene regulatory mechanisms are complex and incompletely understood. The non-steroidal anti-inflammatory Compound A (CpdA), a selective GR modulating compound in variou
Autor:
Michael B. Drennan, S. Van Calenbergh, Lennart Zabeau, Mérédis Favreau, Sylvia Faict, E. De Bruyne, Srinath Govindarajan, Karin Vanderkerken, Eline Menu, Dirk Elewaut, Ken Maes, Koen Venken, Jan Tavernier, Djoere Gaublomme, Xavier Leleu
Publikováno v:
Leukemia. 31(12)
A hallmark of bone marrow changes with aging is the increase in adipocyte composition, but how this impacts development of multiple myeloma (MM) is unknown. Here, we report the role of the adipokine leptin as master regulator of anti-myeloma tumor im
Autor:
Savvas N. Savvides, Jan Tavernier, Yehudi Bloch, Frank Peelman, Laurens Vyncke, Loes van Schie, Ewald Pauwels, Kenneth Verstraete
Publikováno v:
Nature Structural & Molecular Biology. 21:375-382
Thymic stromal lymphopoietin (TSLP), a cytokine produced by epithelial cells at barrier surfaces, is pivotal for the development of widespread chronic inflammatory disorders such as asthma and atopic dermatitis. The structure of the mouse TSLP-mediat
Autor:
Dariusz Ratman, Lode De Cauwer, Nathalie Hennuyer, Réjane Paumelle, Michał Pawlak, Nadia Bougarne, Sandrine Caron, Viacheslav Mylka, Claude Libert, Karolien De Bosscher, Bart Staels, Mark H. Rider, Jonathan Thommis, Jan Tavernier, Sam Lievens
Publikováno v:
Nucleic Acids Research, Vol. 44, no. 22, p. 10539-10553 (2016)
NUCLEIC ACIDS RESEARCH
Nucleic Acids Research
NUCLEIC ACIDS RESEARCH
Nucleic Acids Research
Adaptation to fasting involves both Glucocorticoid Receptor (GRα) and Peroxisome Proliferator-Activated Receptor α (PPARα) activation. Given both receptors can physically interact we investigated the possibility of a genome-wide cross-talk between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f5d899f09077c750a128bd64713cef
https://hdl.handle.net/2078.1/212854
https://hdl.handle.net/2078.1/212854