Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Lu Gan"'
Autor:
Di Zhu, Zhen Zhang, Jianli Zhao, Demin Liu, Lu Gan, Wayne Bond Lau, Dina Xie, Zhijun Meng, Peng Yao, Jumpei Tsukuda, Theodore A. Christopher, Bernard L. Lopez, Erhe Gao, Walter J. Koch, Yajing Wang, Xin-Liang Ma
Publikováno v:
Circulation Research. 131
Background: Despite significantly reduced acute myocardial infarction (MI) mortality in recent years, ischemic heart failure continues to escalate. Therapeutic interventions effectively reversing pathological remodeling are an urgent unmet medical ne
Autor:
Erya Chen, Sruthi Katakam, Jin Liu, Xu Cheng, Lu Gan, Yanhua Qiu, Ming Li, Zhendong Niu, Hai Chen, Rui Gao, Hai Yu, Ronghua Zhou, Tao Zhu, Shu Zhang, Xing-Wei Cai, Qiao Wang, Chan Chen
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 5, Iss 1, Pp 1-15 (2020)
Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy
Emerging evidence suggests that Toll-like receptors (TLRs) ligands pretreatment may play a vital role in the progress of myocardial ischemia/reperfusion (I/R) injury. As the ligand of TLR3, polyinosinic-polycytidylic acid (poly(I:C)), a synthetic dou
Publikováno v:
Molecular and cellular endocrinology. 548
Adult mammalian cardiomyocytes (CMs) lose their proliferative potential due to cell-cycle withdrawal and polyploidization and fail to mount a proliferative response to regenerate new CMs after cardiac injury. The decline in the proliferative potentia
Autor:
Xin-Liang Ma, Erhe Gao, Wayne Bond Lau, Yajing Wang, Rui Guo, Zheyi Yan, Dina Xie, Bernard L. Lopez, Theodore A. Christopher, Lu Gan
Publikováno v:
Circulation Journal. 83:1726-1736
Background Withaferin A (WFA), an anticancer constituent of the plant Withania somnifera, inhibits tumor growth in association with apoptosis induction. However, the potential role of WFA in the cardiovascular system is little-studied and controversi
Autor:
Walter J. Koch, Erhe Gao, Bin Liang, Wayne Bond Lau, Lu Gan, Rui Guo, Yajing Wang, Wenjun Yan, Zheyi Yan, Yunhui Du, Jianli Zhao, Xin-Liang Ma
Publikováno v:
Autophagy. 13:1855-1869
Macroautophagy/autophagy is increasingly recognized as an important regulator of myocardial ischemia-reperfusion (MI-R) injury. However, whether and how diabetes may alter autophagy in response to MI-R remains unknown. Deficiency of ADIPOQ, a cardiop
Publikováno v:
Phytomedicine : international journal of phytotherapy and phytopharmacology. 63
Background Genkwanin is a flavone isolated from the traditional Chinese herb Daphne genkwa. Our previous work proved that four flavonoids (including genkwanin) isolated from D. genkwa (FFD) significantly improved the symptoms of arthritis in rat mode
Publikováno v:
Immunobiology. 220:947-953
The suppressor of cytokine signaling 3 (SOCS3) is an established negative feedback regulation transcription factor associated with leptin, tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and growth hormone (GH). However, the regulatory mech
Publikováno v:
Molecular Biology Reports. 41:627-637
In order to investigate the mechanism of suppressor of cytokine signaling 2 (SOCS2) on mitochondrial biogenesis, RNA interference and over-expression plasmid vectors of SOCS2 were used to transfect murine skeletal muscle C2C12 cells. Results demonstr
Publikováno v:
Molecular Biology Reports. 40:7017-7025
Adiponectin is an adipokine hormone that influences glucose utilization, insulin sensitivity and energy homeostasis. To investigate the effect of adiponectin on lipids deposition in broilers, rosiglitazone and dexamethasone were used to treat broiler
Publikováno v:
Scientific Reports
Alpha melanocyte stimulating hormone (α-MSH) and Forkhead box C2 protein (Foxc2) enhance lipolysis in multiple tissues. However, their relationship in adipose fatty acid oxidation (FAO) remains unclear. Here, we demonstrated that α-MSH and Foxc2 in