Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Henry Brown"'
Autor:
Niall M. B. Martin, Bastiaan Evers, Charlotte Knights, Janneke E. Jaspers, Jos Jonkers, Attilla Ting, Henry Brown, Keith W. Caldecott, Sven Rottenberg, Rajesh Odedra, Lenka Oplustil O'Connor, Robert Hugh Bradbury, Aaron Cranston, David Alan Rudge, Mark J. O'Connor, Marina Pajic, Louise J. Jones, Alan Lau, Stuart L. Rulten
Publikováno v:
Cancer Research. 76:6084-6094
The PARP inhibitor AZD2461 was developed as a next-generation agent following olaparib, the first PARP inhibitor approved for cancer therapy. In BRCA1-deficient mouse models, olaparib resistance predominantly involves overexpression of P-glycoprotein
Autor:
Catherine Anne Eberlein, Garry Beran, Eiki Ichihara, William Pao, Zhongwu Lai, Henry Brown, Daniel Stetson, Paul R. Fisher, Jonathan R. Dry, Claire Barnes, Ambar Ahmed, Paul D. Smith, Miika Ahdesmaki, Paula J. Spitzler, Catherine B. Meador, Darren Cross, Elizabeth L. Christey O'Brien, Sarah Ross, Katherine Al-Kadhimi, Kenneth S. Thress, Laura E. Ratcliffe, Brian Dougherty, Aleksandra Markovets
Publikováno v:
Cancer Research. 75:2489-2500
Resistance to targeted EGFR inhibitors is likely to develop in EGFR-mutant lung cancers. Early identification of innate or acquired resistance mechanisms to these agents is essential to direct development of future therapies. We describe the detectio
Publikováno v:
Toxicology and applied pharmacology. 53(2)
Urea cycle enzyme activities may be determined through the colorimetric analysis of urea and citrulline, which are intermediates in the cycle. A new semiautomated method was used to measure the activities of carbamyl phosphate synthetase, ornithine t
Autor:
Robert Blakemore, G. J. Durant, D. A. A. Owen, Charon R. Ganellin, Thomas Henry Brown, C. A. Harvey, Michael E. Parsons, A. C. Rasmussen, G. S. Sach, D. G. Cooper, Robert John Ife
Publikováno v:
New England and regional allergy proceedings. 7(2)
SK&F 93319 (icotidine), 2-[4-(3-methoxypyrid-2-yl)butylamino]-5-[(6-methylpyrid-3-yl )-methyl]- pyrimidin-4-one trihydrochloride, has been identified as a novel agent which combines into one molecule the ability to antagonize the actions of histamine
Autor:
Julie Brown, Henry Brown
Publikováno v:
JAMA: The Journal of the American Medical Association. 192:382
Urea cycle enzymes which broadly control ammonia metabolism in the liver are being investigated after experimental portacaval shunt operations. The shunt operation has received considerable attention from clinicians because it is a definitive treatme