Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Mazzone, A."'
Autor:
Steven Van Laere, Mieke Dewerchin, Lena-Christin Conradi, Peter Carmeliet, Anna Rita Cantelmo, Federico Taverna, Massimiliano Mazzone, Yonglun Luo, Stefan Vinckier, Stefaan J. Soenen, Nuphar Veiga, Tobias K. Karakach, Peter B. Vermeulen, Lucas Treps, Joanna Kalucka, Sébastien J. Dumas, Luc Dirix, Elda Meta, Shawez Khan, Vincent Geldhof, Guy Eelen, Laure-Anne Teuwen, Luc Schoonjans, Nadine V. Conchinha, Katerina Rohlenova, Lisa M. Becker, Anne Cuypers, Melissa García-Caballero, Laura P.M.H. de Rooij, Jacob Amersfoort
Publikováno v:
Teuwen, L-A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L-C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, pp. 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Teuwen, L A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Cell Reports, Vol 35, Iss 11, Pp 109253-(2021)
Cell reports
Cell Reports
Teuwen, L A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Cell Reports, Vol 35, Iss 11, Pp 109253-(2021)
Cell reports
Cell Reports
Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells in tumors growing via vessel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec69ffb517f91c2c67be4491da86f10
https://lirias.kuleuven.be/handle/123456789/676947
https://lirias.kuleuven.be/handle/123456789/676947
Autor:
Elisabeth Wyart, Myriam Y Hsu, Roberta Sartori, Erica Mina, Valentina Rausch, Elisa S Pierobon, Mariarosa Mezzanotte, Camilla Pezzini, Laure B Bindels, Andrea Lauria, Fabio Penna, Emilio Hirsch, Miriam Martini, Massimiliano Mazzone, Antonella Roetto, Simonetta Geninatti Crich, Hans Prenen, Marco Sandri, Alessio Menga, Paolo E Porporato
Publikováno v:
EMBO reports, Vol. 23, no. 4, p. e53746 [1-18] (2022)
EMBO reports
EMBO reports
Cachexia is a wasting syndrome characterized by devastating skeletal muscle atrophy that dramatically increases mortality in various diseases, most notably in cancer patients with a penetrance of up to 80%. Knowledge regarding the mechanism of cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d164e10bc10921438ac67e2ce268fcd
https://hdl.handle.net/2078.1/259079
https://hdl.handle.net/2078.1/259079
Autor:
Massimiliano Mazzone, Ping-Chih Ho, Carla Riera-Domingo, Fátima Baltazar, Sara Granja, Annette Audigé, Christian Stockmann, Wan-Chen Cheng
Publikováno v:
Physiological Reviews
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
It is generally accepted that metabolism is able to shape the immune response. Only recently we are gaining awareness that the metabolic crosstalk between different tumor compartments strongly contributes to the harsh tumor microenvironment (TME) and
Autor:
Mate Kiss, Geert Raes, Maryse Schmoetten, Helena Van Damme, Andy Wullaert, Jiri Keirsse, Mohamed Lamkanfi, Yvon Elkrim, Pauline M. R. Bardet, Junbin Qian, Aleksandar Murgaski, Louis Boon, Diether Lambrechts, Samantha Pretto, Alain Beschin, Geert van Loo, Massimiliano Mazzone, Manuel Ehling, Jo A. Van Ginderachter, Damya Laoui, Sana M. Arnouk, Evangelia Bolli, Ayla Debraekeleer, Amelie Fossoul, Els Lebegge, Jan Brughmans, Lieselotte Vande Walle, Pedro Henrique Viana Saavedra
IL1β is a central mediator of inflammation. Secretion of IL1β typically requires proteolytic maturation by the inflammasome and formation of membrane pores by gasdermin D (GSDMD). Emerging evidence suggests an important role for IL1β in promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ecbd8e2b94bd021c47f81139d016a57
https://doi.org/10.1158/2326-6066.cir-20-0431
https://doi.org/10.1158/2326-6066.cir-20-0431
Autor:
Elaheh Nasrollahzadeh, Massimiliano Mazzone, Sepideh Razi, Nima Rezaei, Mahsa Keshavarz-Fathi
The tumor microenvironment (TME) not only facilitates cancer progression from the early formation to distant metastasis, but also it differs itself from time to time alongside the tumor evolution. Tumor-associated macrophages (TAMs), whether as pre-e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6bf9ff434c1e4c75ce02b00ca3e1ac
http://hdl.handle.net/2318/1840939
http://hdl.handle.net/2318/1840939
Publikováno v:
The FEBS Journal. 285:700-716
From the evidence on clinical studies and experimental mouse models we now know that tumor-associated macrophages (TAMs) sustain tumor development in many different ways. They play a role in angiogenesis, tumor cell invasion, and metastasis formation
Autor:
Gabriele Bergers, Massimiliano Mazzone
Publikováno v:
Annual Review of Physiology
Research over the last decades has provided strong evidence for the pivotal role of the tumor-associated blood and lymphatic vasculature in supporting immunoevasion and in subverting T cell-mediated immunosurveillance. Conversely, tumor blood and lym
Autor:
Diether Lambrechts, Hans Prenen, Miriam Koopman, Timo Gaiser, Massimiliano Mazzone, Jeroen Depreeuw, Bozena Fender, Chiara Cremolini, Neerincx Maarten, Elaine W. Kay, Annette T. Byrne, Johannes Betge, Orna Bacon, Bram Boeckx, William M. Gallagher, Ian S. Miller, Ana Barat, Bruce Moran, Cornelis J. A. Punt, Sudipto Das, Jochen H. M. Prehn, Bryan T. Hennessy, Verena Murphy, Fotios Loupakis, Henk M.W. Verheul, Dominiek Smeets, Joseph Brady, Deborah A. McNamara, Darran P. O'Connor, Nicole C.T. van Grieken, Matthias P. Ebert, Bauke Ylstra, Rut Klinger
Publikováno v:
Smeets, D, Miller, I S, O'Connor, D P, Das, S, Moran, B, Boeckx, B, Gaiser, T, Betge, J, Barat, A, Klinger, R, van Grieken, N C T, Cremolini, C, Prenen, H, Mazzone, M, Depreeuw, J, Bacon, O, Fender, B, Brady, J, Hennessy, B T, McNamara, D A, Kay, E, Verheul, H M, Maarten, N, Gallagher, W M, Murphy, V, Prehn, J H M, Koopman, M, Punt, C J A, Loupakis, F, Ebert, M P A, Ylstra, B, Lambrechts, D & Byrne, A T 2018, ' Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy ', Nature Communications, vol. 9 . https://doi.org/10.1038/s41467-018-06567-6
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature communications, 9(1):4112. Nature Publishing Group
Nature Communications
Nature Communications, 9. Nature Publishing Group
Nature communications
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature communications, 9(1):4112. Nature Publishing Group
Nature Communications
Nature Communications, 9. Nature Publishing Group
Nature communications
Increased copy number alterations (CNAs) indicative of chromosomal instability (CIN) have been associated with poor cancer outcome. Here, we study CNAs as potential biomarkers of bevacizumab (BVZ) response in metastatic colorectal cancer (mCRC). We c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de0ef61d96ca218d2b20f4e312d92b6b
https://research.vumc.nl/en/publications/8bc01d22-7f99-47bf-a4a0-946c1ff5ab5e
https://research.vumc.nl/en/publications/8bc01d22-7f99-47bf-a4a0-946c1ff5ab5e
Publikováno v:
Oncogene
A lot of attention has been dedicated to investigate the role of the tyrosine kinase receptor MET in tumors. The acquired notion that cancer cells from different histological origin strictly rely on the engagement of this specific oncogene for their
Autor:
Hans Prenen, Massimiliano Mazzone
Publikováno v:
Cellular and molecular life sciences
Macrophages play an important role in tissue development and homeostasis. They serve as a nexus between adaptive and innate immunity, and employ considerable plasticity. In cancer, they play a pivotal role in chronic inflammation and tumor growth eit