Zobrazeno 1 - 9
of 9
pro vyhledávání: '"David Lyden"'
Autor:
Raghu P. Kataru, Babak J. Mehrara, Catherine L. Ly, Hyeung Ju Park, Sagrario Ortega, David Lyden, Jung Eun Baik, Jinyeon Shin, Sonia Rehal
Publikováno v:
Cancer Immunology Research. 7:1345-1358
Proliferation of aberrant, dysfunctional lymphatic vessels around solid tumors is a common histologic finding. Studies have shown that abnormalities in lymphatic function result in accumulation of inflammatory cells with an immunosuppressive profile.
Autor:
Jane Zhang, Rachel Yanowitch, Yujie Huang, William S. Cobb, Jeffrey P. Greenfield, Prajwal Rajappa, Babacar Cisse, David J. Pisapia, Beiyi Shen, Jason T. Huse, Jacqueline Bromberg, David Lyden, Caitlin Hoffman, Kunal Garg, Timothy A. Chan, Sara Haddock, Laura Daly, Emma Vartanian
Publikováno v:
Clinical Cancer Research. 23:3109-3119
Purpose: While the tumor microenvironment has been known to play an integral role in tumor progression, the function of nonresident bone marrow–derived cells (BMDC) remains to be determined in neurologic tumors. Here we identified the contribution
Autor:
Yaron S.N. Butterfield, David Shih, Janet C. Lindsey, Olivier Ayrault, James T. Rutka, Carlos Gilberto Carlotti, Borja L. Holgado, Livia Garzia, Ji Yeoun Lee, Paul A. Northcott, Laura K. Donovan, K. A. Michealraj, Vijay Ramaswamy, Toshihiro Kumabe, Nada Jabado, Thomas Zeng, Michael A. Grotzer, Michael D. Taylor, Jessica Liu, Darlene Lee, Eric Chuah, Gudrun Fleischhack, Scott Zuyderduyn, Xi Huang, Andrey Korshunov, Jacqueline E. Schein, Steven C. Clifford, Ute Bartels, V. Peter Collins, Peter B. Dirks, Stuart Matan-Lithwick, Claudia C. Faria, Daniel W. Fults, Xiao-Nan Li, Tobey J. MacDonald, Yusanne Ma, Mikhail Bilenky, Inanc Birol, Gary D. Bader, Nina Thiessen, Anne Bendel, Marc Remke, Eloi Mercier, Alex Manno, Haiyan I. Li, William A. Weiss, Stéphanie Puget, Noreen Dhalla, Marco A. Marra, Wendy J. Ingram, Sohrab P. Shah, Stefan M. Pfister, Ulrich Schüller, José Pimentel, Jaroslav Sterba, Marcel Kool, Ronald L. Hamilton, Lei Qin, Seung-Ki Kim, An He, Trevor J. Pugh, Stephen C. Mack, Kory Zayne, Xin Wang, Yoon Jae Cho, Kyu-Chang Wang, Patryk Skowron, Betty Luu, Ian F. Pollack, Cynthia Hawkins, Erwin G. Van Meir, Salomeh Jelveh, Andrew J. Mungall, Caitlin Hoffman, Andrew W. Walter, Helen Wheeler, Adi Rolider, Young Cheng, Michael K. Cooper, A. Sorana Morrissy, Jüri Reimand, Uri Tabori, Michael Mayo, Hamza Farooq, Florence M.G. Cavalli, Maria Luisa Garrè, Eric Bouffet, Adrian Ally, Richard A. Moore, Yongjun Zhao, Duncan Stearns, William Long, Richard Corbett, Karel Zitterbart, Yisu Li, Jeffrey H. Wisoff, Tina Wong, Robert J. Wechsler-Reya, Simon Bailey, Yuan Yao Thompson, Lara S. Collier, Luca Massimi, Andrew R. Hallahan, Byung Kyu Cho, Torsten Pietsch, David Lyden, Teiji Tominaga, Angela Tam, James Garvin, Roger J. Packer, John Peacock, Jeffrey J. Olson, Karey Shumansky, Adam J. Dupuy, Kane Tse, David A. Largaespada, Sandra E. Dunn, David T.W. Jones, Young Shin Ra, Patricia Lindsay, Tarek Shalaby, Rebecca Carlsen, Patrick Plettner, Andrew Roth, Chelsea Mayoh, Karen Mungall, Charles G. Eberhart, Xiaochong Wu, Daniela Pretti da Cunha Tirapelli, Sofia Nunes, Jenny Q. Qian, David Malkin, Maura Massimino, John J.Y. Lee, Steven J.M. Jones, Stephan Tippelt, Carolina Nor, Noriyuki Kijima
Publikováno v:
Nature. 529(7586)
The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma wi
Autor:
Barbara Ferris, Beate Heissig, Malcolm A.S. Moore, Ronald G. Crystal, Koichi Hattori, Shahin Rafii, Neil R. Hackett, Zena Werb, Sergio Dias, Matthias Friedrich, Peter Besmer, David Lyden
Publikováno v:
Cell. 109:625-637
Stem cells within the bone marrow (BM) exist in a quiescent state or are instructed to differentiate and mobilize to circulation following specific signals. Matrix metalloproteinase-9 (MMP-9), induced in BM cells, releases soluble Kit-ligand (sKitL),
Autor:
Hannah K. Lederman, Shahin Rafii, Rosandra N. Kaplan, Stefano Rivella, Stephen B. Doty, Dimitris Skokos, April S. Chan, Kristian Jensen, David Lyden
Publikováno v:
PLoS ONE, Vol 4, Iss 11, p e7955 (2009)
PLoS ONE
PLoS ONE
Background The bone-bone marrow interface is an area of the bone marrow microenvironment in which both bone remodeling cells, osteoblasts and osteoclasts, and hematopoietic cells are anatomically juxtaposed. The close proximity of these cells natural
Autor:
Koichi Hattori, David Lyden, Larry Witte, Ronald G. Crystal, Daniel J. Hicklin, Malcolm A.S. Moore, Beate Heissig, Sergio Dias, Zhenping Zhu, Masatoshi Tateno, Shahin Rafii, Neil R. Hackett
Publikováno v:
The Journal of Experimental Medicine
Tyrosine kinase receptors for angiogenic factors vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1) are expressed not only by endothelial cells but also by subsets of hematopoietic stem cells (HSCs). To further define their role in
Autor:
David Lyden, Sally A. Huber
Publikováno v:
Cellular Immunology. 87:462-472
Male Balb/c mice inoculated with a heart-adapted variant of coxsackievirus, group B, type 3 (CVB3M) develop severe myocarditis characterized by extensive focal lesions of inflammatory cells and necrosis of the myocardium. Females generally develop mi
Publikováno v:
Cellular immunology. 105(2)
The severity of cardiac lesions in coxsackievirus group B, type 3 (CVB3)-infected Balb/c mice depends upon both the age and the sex of the animal at the time of viral inoculation. Suckling animals (1-3 weeks old) of either sex develop few cardiac les
Publikováno v:
Cellular immunology. 98(1)
Coxsackievirus group B type 3 (CVB3) induces myocarditis in male Balb/c mice but produces little cardiac injury in females. Males develop cytolytic T lymphocytes (CTL) reactive to heart antigens which primarily cause the inflammation and cardiac inju