Zobrazeno 1 - 10
of 1 097
pro vyhledávání: '"11"'
Autor:
Lisa A. Carey, Patrick L. Leslie, Yvonne L. Chao, Alessandro Porrello, Yi-Hsuan Tsai, Emily B. Harrison, Joel S. Parker, Subrata K. Ghosh, Brian C. Cooley, Chad V. Pecot, Amanda E.D. Van Swearingen
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
Lymph node (LN) metastases correspond with a worse prognosis in nearly all cancers, yet the occurrence of cancer spreading from LNs remains controversial. Additionally, the mechanisms explaining how cancers survive and exit LNs are largely unknown. H
Autor:
Eliza Kwiatkowska-Borowczyk, Anna Kowalik, Andrzej Marszałek, Hanna Dams-Kozlowska, Andrzej Mackiewicz, Sebastian Adamczyk, Ewa Leporowska, Anna Lewandowska, Katarzyna Gryska
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154520 (2016)
PLoS ONE
PLoS ONE
The incidence of cancer is constantly increasing. Chemo/radiotherapy is one of major methods of treating cancer. Although adverse chemo/radiotherapy events, such as anemia and neutropenia, can be successfully cured, thrombocytopenia is still problema
Autor:
Alexander Gow, Farhad Ghoddoussi, Shane A. Perrine, Kathleen J. Maheras, Marcello Peppi, Matthew P. Galloway
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-16 (2018)
Scientific Reports
Scientific Reports
Neuronal origins of behavioral disorders have been examined for decades to construct frameworks for understanding psychiatric diseases and developing useful therapeutic strategies with clinical application. Despite abundant anecdotal evidence for whi
Autor:
Francis G. Szele, Susana Frago, Nicholas B. Davies, Mirvat Surakhy, Martin Ducker, Claudia Bühnemann, Matthew P. Crump, Emma J. Carter, Sermet Can, Roman Trikin, A. Bassim Hassan, Jennifer Hughes
Publikováno v:
Scientific Reports
Hughes, J, Surakhy, M, Can, S, Ducker, M, Davies, N, Szele, F, Bühnemann, C, Carter, E, Trikin, R, Crump, M P, Frago, S & Hassan, A B 2019, ' Maternal transmission of an Igf2r domain 11 : IGF2 binding mutant allele (Igf2r I1565A ) results in partial lethality, overgrowth and intestinal adenoma progression ', Scientific Reports, vol. 9, no. 1, 11388 . https://doi.org/10.1038/s41598-019-47827-9
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
Hughes, J, Surakhy, M, Can, S, Ducker, M, Davies, N, Szele, F, Bühnemann, C, Carter, E, Trikin, R, Crump, M P, Frago, S & Hassan, A B 2019, ' Maternal transmission of an Igf2r domain 11 : IGF2 binding mutant allele (Igf2r I1565A ) results in partial lethality, overgrowth and intestinal adenoma progression ', Scientific Reports, vol. 9, no. 1, 11388 . https://doi.org/10.1038/s41598-019-47827-9
Scientific Reports, Vol 9, Iss 1, Pp 1-16 (2019)
The cation-independent mannose 6-phosphate/insulin-like growth factor-2 receptor (M6P/IGF2R or IGF2R) traffics IGF2 and M6P ligands between pre-lysosomal and extra-cellular compartments. Specific IGF2 and M6P high-affinity binding occurs via domain-1
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 9, p e74838 (2013)
PLoS ONE, Vol 8, Iss 9, p e74838 (2013)
Here we describe a novel, spontaneous, 4035 basepairs long deletion in the DNA cross-link repair 1C (Dclre1c)-locus in C57BL/6-mice, which leads to loss of exons 10 and 11 of the gene encoding for Artemis, a protein involved into V(D) J-recombination
Autor:
Jitske Jansen, Marinka Bakker-van Bebber, Fieke Mooren, Markus A. Loeven, Brigith Willemsen, Jennifer Eymael, Catherine Meyer-Schwesinger, Bart Smeets, Shagun Sharma, Jack F.M. Wetzels, Henry B.P.M. Dijkman, Johan van der Vlag, Laura Miesen
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports, 10
Scientific Reports
Scientific Reports, 10
Scientific Reports
Anti-Thy1.1 transgenic mice develop glomerular lesions that mimic collapsing focal segmental glomerulosclerosis (FSGS) in humans with collapse of the glomerular tuft and marked hyperplasia of the parietal epithelial cells (PECs). Immunostaining of ph
Autor:
Jeroen H. F. de Baaij, Steef Kurstjens, Mohamed Kebieche, Hacene Bouras, Joost G. J. Hoenderop, Caro Overmars-Bos, René J. M. Bindels
Publikováno v:
Scientific Reports, 9
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Approximately 30% of patients with type 2 diabetes mellitus (T2D) have hypomagnesemia (blood magnesium (Mg2+) concentration 2+ levels. To investigate how T2D and metformin affect Mg2+ homeostasis db/m and db/db mice were treated with metformin or pla
Autor:
Maicas, Nuria, van der Vlag, Johan, Bublitz, Janin, Florquin, Sandrine, Bakker-van Bebber, Marinka, Dinarello, Charles A, Verweij, Vivienne, Masereeuw, Roos, Joosten, Leo A, Hilbrands, Luuk B, Afd Pharmacology, Pharmacology
Publikováno v:
PLoS ONE
PLoS One, 12(2). Public Library of Science
PLoS ONE, 12(2). Public Library of Science
PLoS ONE, Vol 12, Iss 2, p e0168981 (2017)
PLoS One, 12, 2
PLoS One, 12
PLoS One, 12(2). Public Library of Science
PLoS ONE, 12(2). Public Library of Science
PLoS ONE, Vol 12, Iss 2, p e0168981 (2017)
PLoS One, 12, 2
PLoS One, 12
Contains fulltext : 169694.pdf (Publisher’s version ) (Open Access) Several lines of evidence have demonstrated the anti-inflammatory and cytoprotective effects of alpha-1-antitrypsin (AAT), the major serum serine protease inhibitor. The aim of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e7a33153e4bf8added9938e158c8be
https://dspace.library.uu.nl/handle/1874/348253
https://dspace.library.uu.nl/handle/1874/348253
Autor:
You-ichi Takizawa, Keisuke Itagaki, Toshiyuki Owaki, Shougo Akari, Ryo Hayashi, Hiroaki Kodama, Takuya Iyoda, Fumio Fukai, Hiroaki Orita, Jyunichi Taira, Yuya Tokita, Yumi Nagamine, Yoshitomi Nakane, Motomichi Fujita, Kazuki Otsuka
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0162525 (2016)
PLoS ONE, Vol 11, Iss 9, p e0162525 (2016)
The acquisition of drug resistance mediated by the interaction of tumor cells with the extracellular matrix (ECM), commonly referred to as cell adhesion-mediated drug resistance (CAM-DR), has been observed not only in hematopoietic tumor cells but al
Autor:
Andreas Ramming, Xiaohan Xu, Walter Birchmeier, Clara Dees, Jingang Huang, Chih-Wei Chen, Ariella Zehender, Yi Nan Li, Kolja Gelse, Christian Beyer, Jörg H W Distler, Georg Schett, Jian-Ping Lin, Andrea Hermina Györfi, Alexandru-Emil Matei, Christina Bergmann, Oliver Distler, Zhong Yin Zhang, Thuong Trinh-Minh
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Uncontrolled activation of TGFβ signaling is a common denominator of fibrotic tissue remodeling. Here we characterize the tyrosine phosphatase SHP2 as a molecular checkpoint for TGFβ-induced JAK2/STAT3 signaling and as a potential target for the tr