Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Jain R"'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in the clinic. Although multiple
Autor:
Stylianopoulos, T., Jain, R. K.
Publikováno v:
Nanomedicine: Nanotechnology, Biology, and Medicine
Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but improvements in overall survival are modest. This is in large part due to the fact that the enhanced perm
Autor:
Vennin, C, Chin, VT, Warren, SC, Lucas, MC, Herrmann, D, Magenau, A, Melenec, P, Walters, SN, Del Monte-Nieto, G, Conway, JRW, Nobis, M, Allam, AH, McCloy, RA, Currey, N, Pinese, M, Boulghourjian, A, Zaratzian, A, Adam, AAS, Heu, C, Nagrial, AM, Chou, A, Steinmann, A, Drury, A, Froio, D, Giry-Laterriere, M, Harris, NLE, Phan, T, Jain, R, Weninger, W, McGhee, EJ, Whan, R, Johns, AL, Samra, JS, Chantrill, L, Gill, AJ, Kohonen-Corish, M, Harvey, RP, Biankin, AV, Australian Pancreatic Cancer Genome Initiative (APGI), Evans, TRJ, Anderson, KI, Grey, ST, Ormandy, CJ, Gallego-Ortega, D, Wang, Y, Samuel, MS, Sansom, OJ, Burgess, A, Cox, TR, Morton, JP, Pajic, M, Timpson, P
The emerging standard of care for patients with inoperable pancreatic cancer is a combination of cytotoxic drugs gemcitabine and Abraxane, but patient response remains moderate. Pancreatic cancer development and metastasis occur in complex settings,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______363::0d5a9b78d701c3ded4723929d771cffb
https://hdl.handle.net/10453/156230
https://hdl.handle.net/10453/156230
Publikováno v:
Cancer research
The stress harbored by the solid phase of tumors is known as solid stress. Solid stress can be either applied externally by the surrounding normal tissue or induced by the tumor itself due to its growth. Fluid pressure is the isotropic stress exerted
Autor:
Baish, J. W., Stylianopoulos, T., Lanning, R. M., Kamoun, W. S., Fukumura, D., Munn, L. L., Jain, R. K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Delivery of blood-borne molecules and nanoparticles from the vasculature to cells in the tissue differs dramatically between tumor and normal tissues due to differences in their vascular architectures. Here we show that two simple measures of vascula
Publikováno v:
Annual Review of Biomedical Engineering
Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, they can increase cells' inva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31342236a2aef544510573096a5bb0b9
http://gnosis.library.ucy.ac.cy/handle/7/48436
http://gnosis.library.ucy.ac.cy/handle/7/48436
Publikováno v:
Cancer research
In solid tumors, angiogenesis occurs in the setting of a defective vasculature and impaired lymphatic drainage that is associated with increased vascular permeability and enhanced tumor permeability. These universal aspects of the tumor microenvironm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c6a59099939ffa8eb56488db65d06c
https://europepmc.org/articles/PMC3876035/
https://europepmc.org/articles/PMC3876035/
Autor:
Chauhan, V. P., Martin, J. D., Liu, H., Lacorre, D. A., Jain, S. R., Kozin, S. V., Stylianopoulos, T., Mousa, A. S., Han, X., Adstamongkonkul, P., Popovic, Z., Huang, P., Bawendi, M. G., Boucher, Y., Jain, R. K.
Publikováno v:
Nature Communications
PMC
PMC
Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan implicated as the primary matrix m
Autor:
Stylianopoulos, T., Martin, J. D., Chauhan, V. P., Jain, S. R., Diop-Frimpong, B., Bardeesy, N., Smith, B. L., Ferrone, C. R., Hornicek, F. J., Boucher, Y., Munn, L. L., Jain, R. K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress intratumoral lymphatic and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05428f95247ff422d39554eb53c974f
http://gnosis.library.ucy.ac.cy/handle/7/48862
http://gnosis.library.ucy.ac.cy/handle/7/48862
Autor:
Wong, C., Stylianopoulos, T., Cui, J., Martin, J., Chauhan, V. P., Jiang, W., Popovic, Z., Jain, R. K., Bawendi, M. G., Fukumura, D.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided only modest survival benefits.