Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Smith, David A."'
Autor:
Karen L Locker, Smith David W, Timothy Harrison, Christopher John Swain, Nadia M.J. Rupniak, Michael J Cumberbatch, Rachel K. Conley, Karen A. Maubach, Louise Hewson, David J. Williamson, Michael Rigby, G Mason, Ruth O'Donnell
Publikováno v:
The Journal of Neuroscience. 22:7730-7736
Substance P receptor [neurokinin 1 (NK(1))] antagonists (SPAs) represent a novel mechanistic approach to antidepressant therapy with comparable clinical efficacy to selective serotonin reuptake inhibitors (SSRIs). Because SSRIs are thought to exert t
Autor:
Stephen M. Fitzjohn, Smith David W, Thomas W. Rosahl, Graham L. Collingridge, Frederick M. Kuenzi, Hui Zheng, Robin A. Morton, Guy R. Seabrook, Mark S. Shearman
Publikováno v:
Neuroscience Letters. 319:37-40
Presenilin-1 (PS1) is intimately involved in cleavage of amyloid precursor protein to form beta-amyloid peptides, certain forms of which aggregate in the brains of patients with Alzheimer's disease (AD). The function(s) of PS1 and its precise involve
Autor:
Thomas W. Rosahl, Robin A. Morton, Frederick M. Kuenzi, Stephen M. Fitzjohn, Graham L. Collingridge, Ceri H. Davies, Huw D. Lewis, Guy R. Seabrook, Smith David W, Mark S. Shearman, David S. Reynolds
Publikováno v:
The Journal of Neuroscience. 21:4691-4698
We have studied synaptic function in a transgenic mouse strain relevant to Alzheimer's disease (AD), overexpressing the 695 amino acid isoform of human amyloid precursor protein with K670N and M671L mutations (APP695SWE mice), which is associated wit
Autor:
Ruth O'Donnell, Raymond G. Hill, James G. Bilsland, Christopher John Swain, Smith David W, Desmond O'Connor, Sarah J. Harper, Michael Rigby, Susan Boyce, Franz Hefti, D Evans, Louise Hewson, L Young, G Mason, L. Bristow, Brian John Williams
Publikováno v:
Neuroscience. 88:257-267
The putative neurotrophic effects of the immunophilin ligand GPI-1046 were evaluated in established experimental systems of neuron survival and axon growth in vitro and in vivo. GPI-1046 marginally increased neurite outgrowth of chick dorsal root gan
Publikováno v:
Neuroscience. 70:329-339
Nerve growth factor regulates the developmental programmed cell death of certain neurons in the peripheral nervous system. The functions of nerve growth factor in the central nervous system are less well characterized. Nerve growth factor withdrawal
Publikováno v:
Neuroscience Letters. 161:4-8
The cellular elements responsible for the uptake of [ 3 H]glycine into rat hippocampal slices were investigated. The diffuse laminar distribution of labelling observed under control conditions was greatly reduced seven days after intrahippocampal inj
Autor:
Smith David W, Sylvain Molon-Noblot, Carmen De Felipe, George McAllister, M.R. Knowles, Fraser Murray, Philippe A. Laroque, Nadia M.J. Rupniak, Paul C. Guest, Kamran Salim, Stephen P. Hunt
Antidepressants are widely prescribed in the treatment of depression, although the mechanism of how they exert their therapeutic effects is poorly understood. To shed further light on their mode of action, we have attempted to identify a common prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1294cf497275d2dd91769a338214b320
http://hdl.handle.net/10261/309118
http://hdl.handle.net/10261/309118
Publikováno v:
Neuroscience letters. 371(1)
Glutamate together with its N-methyl-d-aspartate (NMDA) receptors has an important role in the transmission of stimuli in the spinal cord. Whilst the expression of the various NMDA receptor subunits within the spinal cord has been investigated the su
Autor:
Huw D. Lewis, David S. Reynolds, Natalie J. Cookson, Lex H.T Van der Ploeg, Gerard R. Dawson, Thomas W. Rosahl, Dirk Beher, Smith David W, Su Qian, Louise Hewson, Michael Jiang, Raj N. Kalaria, Mark S. Shearman
Publikováno v:
Neurobiology of aging. 25(9)
A homogeneous time-resolved fluorescence immunoassay for detection of beta-amyloid (A beta) peptides has been adapted for quantification of A beta(40) and A beta(42) accumulation in brains of APP695SWE transgenic mice. These over-express human beta A
Autor:
Smith David W, Margaret S. Beer, George McAllister, Michael Rigby, Robert P. Heavens, Kamran Salim, Josephine A. Stanton
Publikováno v:
Annals of the New York Academy of Sciences. 905
EDG receptors are a family of closely related G-protein-coupled receptors, so-called since the first family member to be cloned is encoded by an endothelial differentiation gene. Of the six family members identified, five use lysophospholipids as the