Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hao Zhu"'
Autor:
Heather L. Ciallella, Daniel P. Russo, Swati Sharma, Yafan Li, Eddie Sloter, Len Sweet, Heng Huang, Hao Zhu
Publikováno v:
Environ Sci Technol
For hazard identification, classification, and labeling purposes, animal testing guidelines are required by law to evaluate the developmental toxicity potential of new and existing chemical products. However, guideline developmental toxicity studies
Autor:
Fan Yao, Yalan Deng, Yang Zhao, Ying Mei, Yilei Zhang, Xiaoguang Liu, Consuelo Martinez, Xiaohua Su, Roberto R. Rosato, Hongqi Teng, Qinglei Hang, Shannon Yap, Dahu Chen, Yumeng Wang, Mei-Ju May Chen, Mutian Zhang, Han Liang, Dong Xie, Xin Chen, Hao Zhu, Jenny C. Chang, M. James You, Yutong Sun, Boyi Gan, Li Ma
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The growing knowledge of ferroptosis has suggested the role and therapeutic potential of ferroptosis in cancer, but has not been translated into effective therapy. Liver cancer, primarily hepatocellular carcinoma (HCC), is highly lethal with limited
Autor:
Ibrahim Nassour, Karolina Brodzik, Hao Zhu, Sotaro Kikuchi, Eunhee Choi, Haishan Gao, Adam C. Yopp, Hongtao Yu, Amit G. Singal
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Nature Communications
Nature Communications
Insulin controls glucose homeostasis and cell growth through bifurcated signaling pathways. Dysregulation of insulin signaling is linked to diabetes and cancer. The spindle checkpoint controls the fidelity of chromosome segregation during mitosis. He
Autor:
Yuki Nishikawa, Tomonori Tamura, Itaru Hamachi, Mikiko Takato, Hao Zhu, Rong Cheng, Alma Fujisawa
Publikováno v:
Journal of the American Chemical Society. 142(37)
Reactive oxygen species (ROS) such as hydrogen peroxide (H2O2) can inflict damage to biomolecules under oxidative stress and also act as signaling molecules at physiological levels. Here we developed a unique chemical tool to elucidate the biological
Publikováno v:
Chemical Society Reviews. 44:4337-4366
Transition metals (d-blocks) are recognized as playing critical roles in biology, and they most often act as cofactors in diverse enzymes; however, improper regulation of transition metal stores is also connected to serious disorders. Therefore, the
Publikováno v:
Journal of the American Chemical Society. 136:12820-12823
Reactive oxygen species (ROS) and cellular oxidant stress have long been associated with cancer. Unfortunately, the role of HClO in tumor biology is much less clear than for other ROS. Herein, we report a BODIPY-based HClO probe (BClO) with ultrasens
Autor:
Yang Zhang, Hao Zhu, Yan Jiang, Qi Qun Tang, Li Qi Xie, Pengyuan Yang, Hao Jie Lu, Xiaohui Liu, You You Zhang, Liang Guo
Publikováno v:
Journal of Proteome Research. 13:1307-1314
Mitotic clonal expansion (MCE) is one of the important events taking place at the early stage during 3T3-L1 adipocyte differentiation. To investigate the mechanism underlying this process, we carried out a temporal proteomic analysis to profile the d
Autor:
Paul Harten, Hao Zhu, Alexander Golbraikh, Alexander Tropsha, Eugene N. Muratov, Todd M. Martin, Douglas M. Young
Publikováno v:
Journal of Chemical Information and Modeling. 52:2570-2578
Prior to using a quantitative structure activity relationship (QSAR) model for external predictions, its predictive power should be established and validated. In the absence of a true external data set, the best way to validate the predictive ability
Publikováno v:
Chemical communications (Cambridge, England). 51(4)
The free Niblue-C6-IMC exists in a folded conformation where fluorescence is quenched, and when it binds to COX-2 in the Golgi apparatus of cancer cells, it is forced to adopt the unfolded state, and then fluorescence is turned on. Niblue-C6-IMC was
Autor:
Tomas Öberg, Anil Kumar Pandey, Roberto Todeschini, Denis Fourches, Alexander Tropsha, Alexandre Varnek, Igor V. Tetko, Iurii Sushko, Ester Papa, Hao Zhu
Publikováno v:
Journal of Chemical Information and Modeling
Journal of Chemical Information and Modeling, American Chemical Society, 2008, 48 (9), pp.1733-1746. ⟨10.1021/ci800151m⟩
Journal of Chemical Information and Modeling, American Chemical Society, 2008, 48 (9), pp.1733-1746. ⟨10.1021/ci800151m⟩
The estimation of the accuracy of predictions is a critical problem in QSAR modeling. The "distance to model" can be defined as a metric that defines the similarity between the training set molecules and the test set compound for the given property i