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pro vyhledávání: '"Carmen Garnacho"'
Autor:
Carmen Garnacho
Publikováno v:
Scopus-Elsevier
Over the last half century, the delivery of pharmacologically active substances, such as synthetic drugs, natural compounds, gene material and many other pharmaceutical products, has been widely studied. Understanding the interactions of drug carrier
Publikováno v:
Molecular Pharmaceutics
Drugs often use endocytosis to achieve intracellular delivery, either by passive uptake from the extracellular fluid or by active targeting of cell surface features such as endocytic receptors. An example is enzyme replacement therapy, a clinically p
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 25(7)
Acid sphingomyelinase deficiency in type B Niemann-Pick disease leads to lysosomal sphingomyelin storage, principally affecting lungs, liver, and spleen. Infused recombinant enzyme is beneficial, yet its delivery to the lungs is limited and requires
Autor:
Carmen Garnacho, John Leferovich, Edward H. Schuchman, Christine Gajewski, Julie A. Champion, Vladimir R. Muzykantov, Samir Mitragotri, Silvia Muro
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 16(8)
Endocytosis in endothelial cells (ECs) is important for many biomedical applications, including drug delivery by nano- and microscale carriers. However, little is known about how carrier geometry influences endothelial drug targeting, intracellular t