Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jain R"'
Autor:
Stylianopoulos, T., Jain, R. K.
Publikováno v:
Nanomedicine: Nanotechnology, Biology, and Medicine
Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but improvements in overall survival are modest. This is in large part due to the fact that the enhanced perm
Publikováno v:
Annual Review of Biomedical Engineering
Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, they can increase cells' inva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31342236a2aef544510573096a5bb0b9
http://gnosis.library.ucy.ac.cy/handle/7/48436
http://gnosis.library.ucy.ac.cy/handle/7/48436
Autor:
Chauhan, V. P., Martin, J. D., Liu, H., Lacorre, D. A., Jain, S. R., Kozin, S. V., Stylianopoulos, T., Mousa, A. S., Han, X., Adstamongkonkul, P., Popovic, Z., Huang, P., Bawendi, M. G., Boucher, Y., Jain, R. K.
Publikováno v:
Nature Communications
PMC
PMC
Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial matrix also contributes to solid stress, with hyaluronan implicated as the primary matrix m
Autor:
Chauhan, V. P., Stylianopoulos, T., Martin, J. D., PopoviÄ, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., Jain, R. K.
Publikováno v:
Nature Nanotechnology
Nature nanotechnology
Nature nanotechnology
The blood vessels of cancerous tumours are leaky and poorly organized. This can increase the interstitial fluid pressure inside tumours and reduce blood supply to them, which impairs drug delivery. Anti-angiogenic therapiesĝwhich ĝ̃ normalizeĝ™
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff36aa98fca5ceee00f40737332d879c
http://gnosis.library.ucy.ac.cy/handle/7/48289
http://gnosis.library.ucy.ac.cy/handle/7/48289
Autor:
Stylianopoulos, T., Martin, J. D., Chauhan, V. P., Jain, S. R., Diop-Frimpong, B., Bardeesy, N., Smith, B. L., Ferrone, C. R., Hornicek, F. J., Boucher, Y., Munn, L. L., Jain, R. K.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The presence of growth-induced solid stresses in tumors has been suspected for some time, but these stresses were largely estimated using mathematical models. Solid stresses can deform the surrounding tissues and compress intratumoral lymphatic and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d05428f95247ff422d39554eb53c974f
http://gnosis.library.ucy.ac.cy/handle/7/48862
http://gnosis.library.ucy.ac.cy/handle/7/48862
Autor:
Wong, C., Stylianopoulos, T., Cui, J., Martin, J., Chauhan, V. P., Jiang, W., Popovic, Z., Jain, R. K., Bawendi, M. G., Fukumura, D.
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Current Food and Drug Administration-approved cancer nanotherapeutics, which passively accumulate around leaky regions of the tumor vasculature because of an enhanced permeation and retention (EPR) effect, have provided only modest survival benefits.
Autor:
Stylianopoulos, T., Poh, M. Z., Insin, N., Bawendi, M. G., Fukumura, D., Munn, L. L., Jain, R. K.
Publikováno v:
Biophysical journal
Diffusive transport of macromolecules and nanoparticles in charged fibrous media is of interest in many biological applications, including drug delivery and separation processes. Experimental findings have shown that diffusion can be significantly hi
Autor:
Chauhan, V., Boucher, Y., Ferrone, C., Roberge, S., Martin, J., Stylianopoulos, T., Bardeesy, N., DePinho, R., Padera, T., Munn, L., Jain, R.
Publikováno v:
Cancer Cell
Impaired perfusion is a hallmark of solid tumors that promotes progression, immunosuppression and treatment-resistance, and is partly caused by vascular compression from excessive extravascular stresses (Chauhan et al., 2013; Stylianopoulos et al., 2
Autor:
S G Kauschke, Qingsong Liu, Barbara Bartosinska, Peter Eickelmann, Nathanael S. Gray, Deepak Kumar Jain, D Schumann, Eckhard Lammert, Jun Wang, Ruchi Jain, Lorenzo Piemonti
Publikováno v:
Diabetologia. 56:1350-1355
Type 2 diabetes is characterised by impaired glucose-stimulated insulin secretion (GSIS) from pancreatic islets. Since erythropoietin-producing hepatoma (Eph)-ephrin bidirectional signalling fine-tunes GSIS from pancreatic beta cells, we investigated
Publikováno v:
Microvascular Research. 65:56-60
Tumor blood flow (TBF) plays a fundamental role in tumor growth and treatment, and is characterized by spatial and temporal heterogeneities. Here we show that the interstitial fluid pressure (IFP), which is higher in tumoral tissue than in normal tis