Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Ali H"'
Autor:
Martin D. Burkhalter, Marco Groth, Friedrich Becker, Yohei Morita, Hans A. Kestler, Sarah E. von Löhneysen, Ali H. Baig, Alush I. Avila, Melanie Philipp, Annika Scheffold, Johann M. Kraus, Stephan Stilgenbauer, André Lechel, Florian Schmid, Zhiyang Chen
Publikováno v:
Leukemia
Accumulation of DNA damage and myeloid-skewed differentiation characterize aging of the hematopoietic system, yet underlying mechanisms remain incompletely understood. Here, we show that aging hematopoietic progenitor cells particularly of the myeloi
Autor:
Jakob J. Metzger, Christian Markopoulos, Szilvia Galgoczi, Ali H. Brivanlou, Anna Yoney, Fred Etoc, Tomomi Haremaki, Albert Ruzo, Tien Phan-Everson, Shu Li
Publikováno v:
Development (Cambridge, England)
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG repeats in the huntingtin gene (HTT). Although HD has been shown to have a developmental component, how early during human embryogenesis the HTT-CAG exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e099c419db7405ce2203773fde32a74a
http://edoc.mdc-berlin.de/20973/1/20973oa.pdf
http://edoc.mdc-berlin.de/20973/1/20973oa.pdf
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
Obesity is a global public health concern associated with increased risk of several comorbidities. Due to the limited effectiveness of current therapies, new treatment strategies are needed. Our aim was to examine the effect of adipose-derived mesenc
Autor:
Wafaa B. Alsoussi, Jackson S. Turner, Rita Chen, Sean P. J. Whelan, James Brett Case, Mahima Thapa, Jane A. O’Halloran, Ali H. Ellebedy, Ishmael D. Aziati, Daniel C. Adelsberg, Zhuoming Liu, Andrianus Boon, Florian Krammer, Fatima Amanat, Tamarand L. Darling, Rachel M. Presti, Aaron J. Schmitz, Astha Joshi, Traci L. Bricker, Tingting Lei, Michael S. Diamond, Goran Bajic, Pei Yong Shi
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
Immunity
article-version (status) pre
article-version (number) 1
Immunity
The emergence of SARS-CoV-2 antigenic variants with increased transmissibility is a public health threat. Some variants show substantial resistance to neutralization by SARS-CoV-2 infection- or vaccination-induced antibodies. Here, we analyzed recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88fc311b327b0c0bbe79f815f070b4cb
https://europepmc.org/articles/PMC8010723/
https://europepmc.org/articles/PMC8010723/
Autor:
Stephan A. Ramos, John W. Kappler, Sheila I. Alizadeh, Loni Perrenoud, Prabha Yadav, Antonio Jimeno, Ali H. Shilleh, James Jaggers, John Morton, Holger A. Russ, Brendan Reed
Publikováno v:
J Allergy Clin Immunol
Background The thymus is a glandular organ that is essential for the formation of the adaptive immune system by educating developing T cells. The thymus is most active during childhood and involutes around the time of adolescence, resulting in a seve
Autor:
Pei-Feng Cheng, Lucas B. Sullivan, Ali H. Ibrahim, Michael Geuenich, Brian Freie, Sydney P. Alibeckoff, Ryan Basom, Adi F. Gazdar, Nan Wu, Joseph B. Hiatt, Haritha Mathsyaraja, David MacPherson, Arnaud Augert, Robert N. Eisenman
Publikováno v:
Cancer Cell
Small cell lung cancer (SCLC) is a highly aggressive and lethal neoplasm. To identify candidate tumor suppressors we applied CRISPR-Cas9 gene inactivation screens to a cellular model of early-stage SCLC. Among the top hits was MAX, the obligate heter
Publikováno v:
Neuroscience. 346:1-13
Peptidergic dorsal root ganglion (DRG) neurons transmit sensory and nociceptive information from the periphery to the central nervous system. Their synaptic activity is profoundly affected by neuromodulatory peptides stored and released from large de
Publikováno v:
Development
Although fate maps of early embryos exist for nearly all model organisms, a fate map of the gastrulating human embryo remains elusive. Here we use human gastruloids to piece together a rudimentary fate map for the human primitive streak (PS). This is
Autor:
Hong Jun Rhee, ChoongKu Lee, Anja Guenther, Carolina Thomas, Erinn S. Gideons, Ali H Shaib, Oliver Brüstle, Kristina Rehbach, Tamara Krutenko, Michael Peitz, Matthias Hebisch, Peter Seif, Jeong-Seop Rhee, Nils Brose
Publikováno v:
Cell Reports, Vol 27, Iss 7, Pp 2212-2228.e7 (2019)
Cell Reports
Cell Reports
Summary: iPSC-derived human neurons are expected to revolutionize studies on brain diseases, but their functional heterogeneity still poses a problem. Key sources of heterogeneity are the different cell culture systems used. We show that an optimized
Autor:
Ute Becherer, Ali H Shaib, Ali Harb, Ahmed Shaaban, Madhurima Dhara, Walentina Frisch, Dieter Bruns, Ralf Mohrmann
Publikováno v:
eLife
eLife, Vol 8 (2019)
eLife, Vol 8 (2019)
SNAP-25 is an essential component of SNARE complexes driving fast Ca2+-dependent exocytosis. Yet, the functional implications of the tandem-like structure of SNAP-25 are unclear. Here, we have investigated the mechanistic role of the acylated “link