Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Kroemer G"'
Autor:
Pietrocola F., Castoldi F., Markaki M., Lachkar S., Chen G., Enot D. P., Durand S., Bossut N., Tong M., Malik S. A., Loos F., Dupont N., Marino G., Abdelkader N., Madeo F., Maiuri M. C., Kroemer R., Codogno P., Sadoshima J., Tavernarakis N., Kroemer G.
Publikováno v:
Cell Reports, Vol 22, Iss 9, Pp 2395-2407 (2018)
Summary: The age-associated deterioration in cellular and organismal functions associates with dysregulation of nutrient-sensing pathways and disabled autophagy. The reactivation of autophagic flux may prevent or ameliorate age-related metabolic dysf
Autor:
Sica V., Bravo-San Pedro J. M., Izzo V., Pol J., Pierredon S., Enot D., Durand S., Bossut N., Chery A., Souquere S., Pierron G., Vartholomaiou E., Zamzami N., Soussi T., Sauvat A., Mondragon L., Kepp O., Galluzzi L., Martinou J. -C., Hess-Stumpp H., Ziegelbauer K., Kroemer G., Maiuri M. C.
Publikováno v:
Cell Reports
Cell Reports, Elsevier Inc, 2019, 27 (3), pp.820-834.e9. ⟨10.1016/j.celrep.2019.03.058⟩
Cell Reports, Vol 27, Iss 3, Pp 820-834.e9 (2019)
Cell Reports, 2019, 27 (3), pp.820-834.e9. ⟨10.1016/j.celrep.2019.03.058⟩
Cell Reports, Elsevier Inc, 2019, 27 (3), pp.820-834.e9. ⟨10.1016/j.celrep.2019.03.058⟩
Cell Reports, Vol 27, Iss 3, Pp 820-834.e9 (2019)
Cell Reports, 2019, 27 (3), pp.820-834.e9. ⟨10.1016/j.celrep.2019.03.058⟩
Summary: Inhibition of oxidative phosphorylation (OXPHOS) by 1-cyclopropyl-4-(4-[(5-methyl-3-(3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl]pyridin-2-yl)piperazine (BAY87-2243, abbreviated as B87), a complex I inhibitor,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::9237f157179cf62166902e847f70abc7
https://hal.sorbonne-universite.fr/hal-02317988
https://hal.sorbonne-universite.fr/hal-02317988
Autor:
Rockenfeller, P, Koska, M, Pietrocola, F, Minois, N, Knittelfelder, O, Sica, V, Franz, J, Carmona-Gutierrez, D, Kroemer, G, Madeo, F
Publikováno v:
Cell Death and Differentiation
This work was supported by the Austrian Science Fund FWF (grants LIPOTOX, I1000-B20, P23490-B12, and P24381-B20) to FM. The authors acknowledge support from NAWI Graz. OK is a member of the PhD program ‘Molecular Enzymology’, funded by the FWF (p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4aed14a0fa347432480c818d37ea217d
https://hdl.handle.net/10023/6250
https://hdl.handle.net/10023/6250
Autor:
Carolina Alves Costa Silva, Deborah Lefevre, Lisa Derosa, Claudia Grajeda-Iglesias, Gladys Ferrere, Maryam Tidjani Alou, Anne-Gaëlle Goubet, Fanny Aprahamian, Conrad Rauber, Didier Raoult, Aurélie Fluckiger, Monica Arnedos, Damien Drubay, Romain Daillère, Cassandra Thelemaque, Tim D. Spector, Sylvère Durand, Liwei Zhao, Guido Kroemer, Emeline Colomba, Oliver Kepp, Valerio Iebba, Laurence Zitvogel, Nicola Segata, Francesco Asnicar, Marine Fidelle, Peng Liu, Bernhard Ryffel
Publikováno v:
JCI Insight
JCI Insight, 2021, 6 (2), ⟨10.1172/jci⟩
JCI Insight, American Society for Clinical Investigation, 2021, 6 (2), ⟨10.1172/jci⟩
JCI Insight, Vol 6, Iss 2 (2021)
JCI Insight, 2021, 6 (2), ⟨10.1172/jci⟩
JCI Insight, American Society for Clinical Investigation, 2021, 6 (2), ⟨10.1172/jci⟩
JCI Insight, Vol 6, Iss 2 (2021)
International audience; Limited experimental evidence bridges nutrition and cancer immunosurveillance. Here, we show that ketogenic diet (KD) - or its principal ketone body, 3-hydroxybutyrate (3HB), most specifically in intermittent scheduling - indu
Autor:
Joseph A. Hill, Frank Madeo, Eugenia Morselli, Naoufal Zamzami, Guido Kroemer, Maria Chiara Maiuri, Mireia Niso-Santano, Federico Pietrocola, Aleksandra Andryushkova, Sabrina Schroeder, Oliver Kepp, Álvaro F. Fernández, Guillermo Mariño, Silvère Durand, Christoph Magnes, Shoaib Ahmad Malik, Tobias Pendl, Frank Sinner, David Enot, Isabelle Martins, Carlos López-Otín, Tobias Eisenberg, Patrice Codogno, Marie Scoazec, Jens S. Andersen, Alexandra Harger, Thomas R. Pieber, Chantal Bauvy, Laura Senovilla, Erika Vacchelli, Yongli Kong, Martin V. Bennetzen
Publikováno v:
Mariño, G, Pietrocola, F, Eisenberg, T, Kong, Y, Malik, S A, Andryushkova, A, Schroeder, S, Pendl, T, Harger, A, Niso-Santano, M, Zamzami, N, Scoazec, M, Durand, S, Enot, D P, Fernández, Á F, Martins, I, Kepp, O, Senovilla, L, Bauvy, C, Morselli, E, Vacchelli, E, Bennetzen, M, Magnes, C, Sinner, F, Pieber, T, López-Otín, C, Maiuri, M C, Codogno, P, Andersen, J S, Hill, J A, Madeo, F & Kroemer, G 2014, ' Regulation of autophagy by cytosolic acetyl-coenzyme A ', Molecular Cell, vol. 53, no. 5, pp. 710-725 . https://doi.org/10.1016/j.molcel.2014.01.016
Acetyl-coenzyme A (AcCoA) is a major integrator of the nutritional status at the crossroads of fat, sugar, and protein catabolism. Here we show that nutrient starvation causes rapid depletion of AcCoA. AcCoA depletion entailed the commensurate reduct
Autor:
Guillermo Mariño, Frank Madeo, Lorenzo Galluzzi, Shensi Shen, Isabelle Martins, Alexander Valent, Bastien Job, Mark J. Smyth, Maria Castedo, Gian Maria Fimia, Mickaël Michaud, Francesco Berardinelli, Claire Pailleret, Alfredo Criollo, Vladimir Lazar, Santiago Rello-Varona, Guillaume Pourcher, Mauro Piacentini, Antonella Sistigu, Vichnou Poirier-Colame, Laura Senovilla, Sylvain Ladoire, Ming Li, Sandy Adjemian, Clara Locher, Ilio Vitale, Takahiro Yamazaki, Christoph Ruckenstuhl, Josef M. Penninger, Monique Talbot, Nicole L Messina, Antonio Antoccia, François Ghiringhelli, Verena Sigl, Fabiola Ciccosanti, Guido Kroemer, Mireia Niso-Santano, Maximilien Tailler, Oliver Kepp, Laurence Zitvogel, Alice Boilève, Carlos López-Otín, Didac Carmona-Gutierrez, Christopher J. Chan, Antonio Fueyo
Publikováno v:
Science. 337:1678-1684
Keeping Cancer Cells At Bay Cancer cells are often aneuploid; that is, they have an abnormal number of chromosomes. But to what extent this contributes to the tumorigenic phenotype is not clear. Senovilla et al. (p. 1678 ; see the Perspective by Zane
Autor:
Guillermo Mariño, Guido Kroemer, Shoaib Ahmad Malik, Oliver Kepp, Lorenzo Galluzzi, Maria Castedo, Maximilien Tailler, Delphine Lissa, Laura Senovilla, Gérard Pierron, Mohamed Jemaà, Francis Harper, Francesco Berardinelli, Santiago Rello-Varona, Ilio Vitale, Frédéric Schlemmer, Antonio Antoccia
Publikováno v:
Scopus
EMBO Molecular Medicine
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
EMBO Molecular Medicine
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
The genetic or functional inactivation of p53 is highly prevalent in human cancers. Using high-content videomicroscopy based on fluorescent TP53(+/+) and TP53(-/-) human colon carcinoma cells, we discovered that SP600125, a broad-spectrum serine/thre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5fbecbbbde297009b0df16e59e3e750
http://hdl.handle.net/10651/41962
http://hdl.handle.net/10651/41962
Autor:
Pierre Rustin, Klas Blomgren, Sylvie Lachkar, Guido Kroemer, A de Andrade, Carsten Culmsee, Nazanine Modjtahedi, Günter U. Höglinger, Gérard Pierron, Gian Maria Fimia, Vladimir Lazar, Matteo Bordi, Emilie Hangen, Francis Harper, Jose Miguel Vicencio, Jean Bénard, Paule Bénit, Mauro Piacentini, J-L Perfettini, Changlian Zhu, Philippe Dessen, D De Zio, F Caffin, Francesco Cecconi
Publikováno v:
Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2010, 17 (7), pp.1155-1166. ⟨10.1038/cdd.2009.211⟩
Cell Death and Differentiation, 2010, 17, pp.1155-1166. ⟨10.1038/cdd.2009.211⟩
Cell Death and Differentiation, Nature Publishing Group, 2010, 17, pp.1155-1166. ⟨10.1038/cdd.2009.211⟩
Cell Death and Differentiation, Nature Publishing Group, 2010, 17 (7), pp.1155-1166. ⟨10.1038/cdd.2009.211⟩
Cell Death and Differentiation, 2010, 17, pp.1155-1166. ⟨10.1038/cdd.2009.211⟩
Cell Death and Differentiation, Nature Publishing Group, 2010, 17, pp.1155-1166. ⟨10.1038/cdd.2009.211⟩
International audience; Apoptosis-Inducing factor (AIF) plays important supportive as well as potentially lethal roles in neurons. Under normal physiological conditions, AIF is a vital redox-active mitochondrial enzyme, whereas in pathological situat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f5b348a10b003c02258773997d95dd7
https://hal.archives-ouvertes.fr/hal-02356575
https://hal.archives-ouvertes.fr/hal-02356575
Autor:
Alfredo Criollo, Carla Ortiz, Lorenzo Galluzzi, M Tailler, I Vitale, Sergio Lavandero, N Joza, Gyorgy Szabadkai, Eugenia Morselli, Maria Castedo, Jordi Molgó, Maria Chiara Maiuri, Jose Miguel Vicencio, Aleck W.E. Jones, Guido Kroemer, Oliver Kepp
Publikováno v:
Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2009, 16 (7), pp.1006-17. ⟨10.1038/cdd.2009.34⟩
Cell Death and Differentiation, Nature Publishing Group, 2009, 16 (7), pp.1006-17. ⟨10.1038/cdd.2009.34⟩
International audience; The inositol 1,4,5-trisphosphate receptor (IP(3)R) is a major regulator of apoptotic signaling. Through interactions with members of the Bcl-2 family of proteins, it drives calcium (Ca(2+)) transients from the endoplasmic reti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2b4a11226452d329ec5fb34ea9af9e8
https://hal.archives-ouvertes.fr/hal-00378189
https://hal.archives-ouvertes.fr/hal-00378189
Autor:
Mickaël Michaud, Evgenia Megalou, Maria Markaki, Alfredo Criollo, Guido Kroemer, Shoaib Ahmad Malik, Eugenia Morselli, Lorenzo Galluzzi, Nektarios Tavernarakis, Frank Madeo, Ilio Vitale, Konstantinos Palikaras, Angela Pasparaki, Maria Chiara Maiuri
Publikováno v:
Europe PubMed Central
Cell Death & Disease
Cell Death & Disease
Caloric restriction and autophagy-inducing pharmacological agents can prolong lifespan in model organisms including mice, flies, and nematodes. In this study, we show that transgenic expression of Sirtuin-1 induces autophagy in human cells in vitro a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e77210dddd7b9bd573dbe4253977bee
http://europepmc.org/abstract/med/21364612
http://europepmc.org/abstract/med/21364612