Zobrazeno 31 - 40
of 267
pro vyhledávání: '"76"'
Autor:
Jiandong Yuan, Fenghua Meng, Zhiyuan Zhong, Yifan Zhang, Na Yu, Shujing Yue, Jiaying Li, Wenxing Gu, Bin Li, Huanli Sun, Rainer Haag
Publikováno v:
Advanced materials (Deerfield Beach, Fla.). 33(39)
Multiple myeloma (MM) is a second ranking hematological malignancy. Despite the fast advancement of new treatments such as bortezormib and daratumumab, MM patients remain incurable and tend to eventually become relapsed and drug-resistant. Developmen
Autor:
Young Nyun Park, Jong Chan Park, Eun Ji Ro, Kang Yell Choi, Woo Shin Kim, Do Sik Min, Woo Jeong Jeong, Sang Kyu Lee, Soung Hoo Jeon
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications
Stability regulation of RAS that can affect its activity, in addition to the oncogenic mutations, occurs in human cancer. However, the mechanisms for stability regulation of RAS involved in their activity and its roles in tumorigenesis are poorly exp
Autor:
Ming-Hai Wang, Hangping Yao, Liang Feng, Tianhao Weng, Chen-Yu Hu, Sreedhar Reddy Suthe, Zhigang Wu
Publikováno v:
Molecular Cancer Therapeutics. 17:2654-2664
Triple-negative breast cancer (TNBC) is a highly diverse group of malignant neoplasia with poor outcome. Currently, the lack of effective therapy has fostered a major effort to discover new targets to treat this malignant cancer. Here we identified t
Publikováno v:
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-1 (2021)
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-1 (2021)
LncRNA TUG1 has been reported to be highly expressed in CRC samples and cells and promoted metastasis by affecting EMT, indicating a poor prognosis for colorectal cancer (CRC). In this study, we determined the underlying mechanism for tumor oncogenes
Autor:
Hong-Mei Ni, Kunpeng Zhao, Qi-Long Chen, Ruolin Zhao, Yu-min He, Chenchen Tang, Sheng-Quan Fang
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 125, Iss, Pp 110028-(2020)
Ganoderma lucidum has salutary effects on tumor treatment, including pancreatic cancer and hepatocellular carcinoma. However, the molecular mechanisms underlying Ganoderma lucidum therapy is obscure. In this study, the Hepa1-6-bearing C57 BL/6 mouse
Autor:
Nicolle, Rémy, Blum, Yuna, Duconseil, Pauline, Vanbrugghe, Charles, Brandone, Nicolas, Poizat, Flora, Roques, Julie, Bigonnet, Martin, Gayet, Odile, Rubis, Marion, Dou, Samir, Elarouci, Nabila, Armenoult, Lucile, Ayadi, Mira, de Reyniès, Aurélien, Giovannini, Marc, Grandval, Philippe, Garcia, Stephane, Canivet, Cindy, Cros, Jérôme, Bournet, Barbara, Buscail, Louis, Moutardier, Vincent, Gilabert, Marine, Iovanna, Juan, Dusetti, Nelson
Publikováno v:
EBioMedicine
EBioMedicine, Vol 57, Iss, Pp 102858-(2020)
EBioMedicine, Vol 57, Iss, Pp 102858-(2020)
BACKGROUNDA significant gap in pancreatic ductal adenocarcinoma (PDAC) patient’s care is the lack of molecular parameters characterizing tumors and allowing a personalized treatment. The goal of this study was to examine whole PDAC transcriptomic p
Autor:
Bin Zhang, Guang-Biao Zhou, Yunchao Huang, San-Hui Gao, Yan-Fei Zhang, Da-Lin Zhang, Min Wang, Liang Ma, Zhihua Liu, Chen Zhang, Hong Yu, Yongchun Zhou, Zhe-Sheng Wen, Qian Hu, Li-Wei Qu, Guizhen Wang, Liang Chen, Changli Wang, Xin-Chun Zhao, Yong Zhao, Jie Liu
Publikováno v:
EBioMedicine, Vol 53, Iss, Pp-(2020)
EBioMedicine
EBioMedicine
Background: How the oncoprotein epidermal growth factor receptor (EGFR) evades proteolytic degradation and accumulates in non-small cell lung cancer (NSCLC) remains unclear, and ubiquitin pathway genes (UPGs) that are critical to NSCLC needs to be sy
Autor:
Eric Glasgow, Hossein Tavana, Seema Agarwal, Sunil Singh, Pradip Shahi Thakuri, Gary D. Luker, Megha Gupta, Ramila Joshi, Alexander Lekan
Publikováno v:
BMC Cancer
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
BMC Cancer, Vol 20, Iss 1, Pp 1-14 (2020)
Background Cell migration and invasion are essential processes for metastatic dissemination of cancer cells. Significant progress has been made in developing new therapies against oncogenic signaling to eliminate cancer cells and shrink tumors. Howev
Autor:
Steve S.-F. Yu, Bo Rong Peng, Mei-Chin Lu, Yu Hsin Chen, Chang-Yih Duh, Jui-Hsin Su, You Ying Chen, Ping-Jyun Sung, Yusheng M. Huang, Kuei Hung Lai
Publikováno v:
Marine Drugs, Vol 18, Iss 2, p 76 (2020)
Marine Drugs
Volume 18
Issue 2
Marine Drugs
Volume 18
Issue 2
In the current study, an NMR spectroscopic pattern-based procedure for probing scalarane derivatives was performed and four new 24-homoscalaranes, lendenfeldaranes A&ndash
D (1&ndash
4), along with three known compounds, 12&alpha
aceto
D (1&ndash
4), along with three known compounds, 12&alpha
aceto
Autor:
Peina Du, Yan Wang, Qimin Zhan, Jie Chen, Dezuo Dong, Yongmei Song, Xuefeng Liu, Zitong Zhao, Weimin Zhang, Qingnan Wu, Ruoxi Hong, Lin Li, Wenchang Xiao, Yunwei Ou
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-18 (2018)
Molecular Cancer
Molecular Cancer
Background The prognosis for esophageal squamous cell carcinoma (ESCC) patients with lymph node metastasis (LNM) is still dismal. Elucidation of the LNM associated genomic alteration and underlying molecular mechanisms may provide clinical therapeuti