Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Mazzone, A."'
Autor:
Steven Van Laere, Mieke Dewerchin, Lena-Christin Conradi, Peter Carmeliet, Anna Rita Cantelmo, Federico Taverna, Massimiliano Mazzone, Yonglun Luo, Stefan Vinckier, Stefaan J. Soenen, Nuphar Veiga, Tobias K. Karakach, Peter B. Vermeulen, Lucas Treps, Joanna Kalucka, Sébastien J. Dumas, Luc Dirix, Elda Meta, Shawez Khan, Vincent Geldhof, Guy Eelen, Laure-Anne Teuwen, Luc Schoonjans, Nadine V. Conchinha, Katerina Rohlenova, Lisa M. Becker, Anne Cuypers, Melissa García-Caballero, Laura P.M.H. de Rooij, Jacob Amersfoort
Publikováno v:
Teuwen, L-A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L-C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, pp. 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Teuwen, L A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Cell Reports, Vol 35, Iss 11, Pp 109253-(2021)
Cell reports
Cell Reports
Teuwen, L A, De Rooij, L P M H, Cuypers, A, Rohlenova, K, Dumas, S J, García-Caballero, M, Meta, E, Amersfoort, J, Taverna, F, Becker, L M, Veiga, N, Cantelmo, A R, Geldhof, V, Conchinha, N V, Kalucka, J, Treps, L, Conradi, L C, Khan, S, Karakach, T K, Soenen, S, Vinckier, S, Schoonjans, L, Eelen, G, Van Laere, S, Dewerchin, M, Dirix, L, Mazzone, M, Luo, Y, Vermeulen, P & Carmeliet, P 2021, ' Tumor vessel co-option probed by single-cell analysis ', Cell Reports, vol. 35, no. 11, 109253 . https://doi.org/10.1016/j.celrep.2021.109253
Cell Reports, Vol 35, Iss 11, Pp 109253-(2021)
Cell reports
Cell Reports
Tumor vessel co-option is poorly understood, yet it is a resistance mechanism against anti-angiogenic therapy (AAT). The heterogeneity of co-opted endothelial cells (ECs) and pericytes, co-opting cancer and myeloid cells in tumors growing via vessel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec69ffb517f91c2c67be4491da86f10
https://lirias.kuleuven.be/handle/123456789/676947
https://lirias.kuleuven.be/handle/123456789/676947
Autor:
Cheng Xu, Sampath Narayanan, Xiaowei Zheng, Sofie Eliasson Angelstig, Jacob Grünler, Allan Zhao, Alessandro Di Toro, Luciano Bernardi, Massimiliano Mazzone, Peter Carmeliet, Marianna Del Sole, Giancarlo Solaini, Elisabete A Forsberg, Ao Zhang, Kerstin Brismar, Tomas A Schiffer, Neda Rajamand Ekberg, Ileana Ruxandra Botusan, Fredrik Palm, Sergiu-Bogdan Catrina
Publikováno v:
eLife, Vol 11 (2022)
Background:Excessive production of mitochondrial reactive oxygen species (ROS) is a central mechanism for the development of diabetes complications. Recently, hypoxia has been identified to play an additional pathogenic role in diabetes. In this stud
Autor:
Matteo Rossi, Kristine Rillaerts, Joost van den Oord, Sarah-Maria Fendt, Peter Vangheluwe, Ana Isabel Oliveira, Erminia Romano, Maria Livia Sassano, Vivek Venkataramani, Hannelore Maes, Corentin Schepkens, Johannes V. Swinnen, Jasper Wouters, Bernhard Michalke, Wim Annaert, Massimiliano Mazzone, Chris Van den Haute, Abhishek D. Garg, Francesca Maria Bosisio, Jean-Marie Colet, Patrizia Agostinis, Monica Vara-Perez
Publikováno v:
The EMBO Journal
BNIP3 is a mitophagy receptor with context‐dependent roles in cancer, but whether and how it modulates melanoma growth in vivo remains unknown. Here, we found that elevated BNIP3 levels correlated with poorer melanoma patient’s survival and deple
Autor:
Bruno M Simões, Andrea Morandi, Giuseppina Comito, Marina Bacci, Simone Romagnoli, Elisabetta Marangoni, Paola Chiarugi, Massimiliano Mazzone, Matteo Ramazzotti, Nicla Lorito, Manuela Ferracin, Simone Luti, Lesley-Ann Martin, Francesca Bianchini, Qiong Gao, Federico Virga, Federica Cappellesso, Matteo Parri, Elisa Giannoni, Luigi Ippolito
Publikováno v:
Bacci, M, Lorito, N, Ippolito, L, Ramazzotti, M, Luti, S, Romagnoli, S, Parri, M, Bianchini, F, Cappellesso, F, Virga, F, Gao, Q, M Simoes, B, Marangoni, E, Martin, L-A, Comito, G, Ferracin, M, Giannoni, E, Mazzone, M, Chiarugi, P & Morandi, A 2019, ' Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer ', Cell Reports, vol. 28, no. 1, pp. 104-118 . https://doi.org/10.1016/j.celrep.2019.06.010
Cell Reports
Cell Reports, Vol 28, Iss 1, Pp 104-118.e8 (2019)
Cell Reports
Cell Reports, Vol 28, Iss 1, Pp 104-118.e8 (2019)
Summary Endocrine therapy (ET) is the standard of care for estrogen receptor-positive (ER+) breast cancers. Despite its efficacy, ∼40% of women relapse with ET-resistant (ETR) disease. A global transcription analysis in ETR cells reveals a downregu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5664329c59d599df510b5e747e3ead8
https://research.manchester.ac.uk/en/publications/e56a3f78-ac97-4b73-80bb-fe009e127fa4
https://research.manchester.ac.uk/en/publications/e56a3f78-ac97-4b73-80bb-fe009e127fa4
Autor:
Maria C. Cid, Sander Willox, Elizabeth A. V. Jones, Giusy Di Conza, Donatella Ponti, Rosa Martín-Pérez, Roser Alba-Rovira, Ward Celus, Massimiliano Mazzone, Manuel Ehling
Publikováno v:
Circ Res
Circulation Research, 127(6), 707-723. LIPPINCOTT WILLIAMS & WILKINS
Circulation Research, 127(6), 707-723. LIPPINCOTT WILLIAMS & WILKINS
Rationale: How endothelial cells (ECs) migrate and form an immature vascular plexus has been extensively studied. Yet, mechanisms underlying vascular remodeling remain poorly established. A better understanding of these processes may lead to the desi
Autor:
Petya B. Georgieva, Fabio Stanchi, Li-Kun Phng, Thomas Mathivet, Holger Gerhardt, Claire Bouleti, Marly Balcer, Joost Dejaegher, Massimiliano Mazzone, Ken Matsumoto, Tina Verschuere, Raf Sciot, Christian Stockmann, Steven De Vleeschouwer, Jochen Belmans, Matthias Van Woensel
Publikováno v:
EMBO Molecular Medicine
Glioma growth and progression are characterized by abundant development of blood vessels that are highly aberrant and poorly functional, with detrimental consequences for drug delivery efficacy. The mechanisms driving this vessel dysmorphia during tu
Autor:
Wouter H. Lamers, Douglas C. Hooper, Rosa Martín-Pérez, Attilio Guarini, Giacoma De Tullio, Bart Ghesquière, Annamaria Quinto, Carla Riera-Domingo, Alessandra Castegna, Erika M. Palmieri, Massimiliano Mazzone, Daniel W. McVicar, Alessio Menga
Publikováno v:
Cell Reports
Cell Reports, 20(7), 1654-1666. Cell Press
Cell reports, 20(7), 1654-1666. Cell Press
Cell Reports, Vol 20, Iss 7, Pp 1654-1666 (2017)
Cell Reports, 20(7), 1654-1666. Cell Press
Cell reports, 20(7), 1654-1666. Cell Press
Cell Reports, Vol 20, Iss 7, Pp 1654-1666 (2017)
Summary Glutamine-synthetase (GS), the glutamine-synthesizing enzyme from glutamate, controls important events, including the release of inflammatory mediators, mammalian target of rapamycin (mTOR) activation, and autophagy. However, its role in macr
Publikováno v:
Cell Reports, Vol 18, Iss 12, Pp 2836-2844 (2017)
Cell Reports
Cell Reports
Summary B55α is a regulatory subunit of the PP2A phosphatase. We have recently found that B55α-associated PP2A promotes partial deactivation of the HIF-prolyl-hydroxylase enzyme PHD2. Here, we show that, in turn, PHD2 triggers degradation of B55α
Autor:
Albert Wolthuis, Diether Lambrechts, Xavier Sagaert, Wouter Everaerts, Junbin Qian, Yingfeng Zheng, Johan Vansteenkiste, Guy Eelen, Luc Schoonjans, Lena-Christin Conradi, Herbert Decaluwé, Alexander Emmert, Stefan Vinckier, Erik Verbeken, Paul De Leyn, Lin Lin, Shawez Khan, Birgit Weynand, Mieke Dewerchin, Lucas Treps, Liliana Sokol, Baki Topal, Bernard Thienpont, Frank J. T. Staal, Rene J. Mclaughlin, Melissa García-Caballero, Jian Wang, Federico Taverna, Peter Carmeliet, Lars Bolund, Dena Panovska, Andreas Pircher, Laure-Anne Teuwen, Yonglun Luo, Huanming Yang, Els Wauters, Joanna Kalucka, Vincent Geldhof, Francis Impens, Jermaine Goveia, Hanibal Bohnenberger, Bram Boeckx, Massimiliano Mazzone, Frederik De Smet, Vincenzo Lagani, Xuri Li, Tobias K. Karakach, Laura P.M.H. de Rooij, Katerina Rohlenova
Publikováno v:
Goveia, J, Rohlenova, K, Taverna, F, Treps, L, Conradi, L-C, Pircher, A, Geldhof, V, de Rooij, L P M H, Kalucka, J, Sokol, L, García-Caballero, M, Zheng, Y, Qian, J, Teuwen, L-A, Khan, S, Boeckx, B, Wauters, E, Decaluwé, H, De Leyn, P, Vansteenkiste, J, Weynand, B, Sagaert, X, Verbeken, E, Wolthuis, A, Topal, B, Everaert, W, Bohnenberger, H, Emmert, A, Panovska, D, De Smet, F, Staal, F J T, Mclaughlin, R J, Impens, F, Lagani, V, Vinckier, S, Mazzone, M, Schoonjans, L, Dewerchin, M, Eelen, G, Karakach, T K, Yang, H, Wang, J, Bolund, L, Lin, L, Thienpont, B, Li, X, Lambrechts, D, Luo, Y & Carmeliet, P 2020, ' An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates ', Cancer Cell, vol. 37, no. 1, pp. 21-36.e13 . https://doi.org/10.1016/j.ccell.2019.12.001
Cancer Cell
Cancer Cell, 37(1), 21-36.e13. CELL PRESS
Cancer Cell
Cancer Cell, 37(1), 21-36.e13. CELL PRESS
Heterogeneity of lung tumor endothelial cell (TEC) phenotypes across patients, species (human/mouse), and models (in vivo/in vitro) remains poorly inventoried at the single-cell level. We single-cell RNA (scRNA)-sequenced 56,771 endothelial cells fro
Autor:
Francesca Mancini, Valentina Monteleone, Andrea Urbani, Emanuela Teveroni, Alfredo Pontecorvi, Marsha Pellegrino, Mara D'Onofrio, Massimiliano Mazzone, Luisa Pieroni, Giusy Di Conza, Fabiola Moretti, Ivan Arisi, Marianna Buttarelli
Publikováno v:
Molecular cancer 16 (2017): 55. doi:10.1186/s12943-017-0626-7
info:cnr-pdr/source/autori:Mancini, Francesca; Teveroni, Emanuela; Di Conza, Giusy; Monteleone, Valentina; Arisi, Ivan; Pellegrino, Marsha; Buttarelli, Marianna; Pieroni, Luisa; D'Onofrio, Mara; Urbani, Andrea; Pontecorvi, Alfredo; Mazzone, Massimiliano; Moretti, Fabiola/titolo:MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability./doi:10.1186%2Fs12943-017-0626-7/rivista:Molecular cancer/anno:2017/pagina_da:55/pagina_a:/intervallo_pagine:55/volume:16
Molecular Cancer
info:cnr-pdr/source/autori:Mancini, Francesca; Teveroni, Emanuela; Di Conza, Giusy; Monteleone, Valentina; Arisi, Ivan; Pellegrino, Marsha; Buttarelli, Marianna; Pieroni, Luisa; D'Onofrio, Mara; Urbani, Andrea; Pontecorvi, Alfredo; Mazzone, Massimiliano; Moretti, Fabiola/titolo:MDM4 actively restrains cytoplasmic mTORC1 by sensing nutrient availability./doi:10.1186%2Fs12943-017-0626-7/rivista:Molecular cancer/anno:2017/pagina_da:55/pagina_a:/intervallo_pagine:55/volume:16
Molecular Cancer
Background Many tumor-related factors have shown the ability to affect metabolic pathways by paving the way for cancer-specific metabolic features. Here, we investigate the regulation of mTORC1 by MDM4, a p53-inhibitor with oncogenic or anti-survival