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Publikováno v:
American journal of physiology. Cell physiology. 323(6)
Stretch activation is defined as a delayed increase in force after rapid stretches. Although there is considerable evidence for stretch activation in isolated cardiac myofibrillar preparations, few studies have measured mechanisms of stretch activati
Publikováno v:
American journal of physiology. Cell physiology. 323(5)
Normal developmental processes, such as those seen during embryonic development and postpartum mammary gland involution, can be reactivated by cancer cells to promote immune suppression, tumor growth, and metastatic spread. In mammalian embryos, pate
Autor:
Matthew D. McGraw, Min Yee, So-Young Kim, Andrew M. Dylag, B. Paige Lawrence, Michael A. O’Reilly
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(5)
Bronchiolitis obliterans (BO) is a debilitating disease of the small airways that can develop following exposure to toxic chemicals as well as respiratory tract infections. BO development is strongly associated with diacetyl (DA) inhalation exposures
Autor:
Andrew Pham, Kim Dore
Publikováno v:
Semin Cell Dev Biol
A significant proportion of brains with Alzheimer's disease pathology are obtained from patients that were cognitively normal, suggesting that differences within the brains of these individuals made them resilient to the disease. Here, we describe re
Autor:
Martina Gáliková, Peter Klepsatel
Publikováno v:
Seminars in Cell & Developmental Biology. 138:104-116
Over the last decade, the combination of genetics, transcriptomic and proteomic approaches yielded substantial insights into the mechanisms behind the synthesis and breakdown of energy stores in the model organisms. The fruit fly Drosophila melanogas
Publikováno v:
Reproduction. 165:171-182
In brief Intrauterine adhesion (IUA) is one of the main causes of female infertility. This study reveals that endoplasmic reticulum stress activation upregulates the TGF-β/SMAD pathway to induce epithelial–mesenchymal transition and promote endome
Autor:
Shang Wang, Irina V Larina
Publikováno v:
Reproduction
In brief In vivo imaging of gametes and embryos in the oviduct enables new studies of the native processes that lead to fertilization and pregnancy. This review article discusses recent advancements in the in vivo imaging methods and insights which c
Publikováno v:
Cold Spring Harbor perspectives in biology. 13(10)
Polyploidy is defined as a cell with three or more whole genome sets and enables cell growth across the kingdoms of life. Studies in model organisms have revealed that polyploid cell growth can be required for optimal tissue repair and regeneration.
Autor:
Sumit Pawar, Ulrike Kutay
Publikováno v:
Cold Spring Harbor Perspectives in Biology, 13 (9)
The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic reticulum (ER) known as the nuclear envelope (NE). Compared to the outer nuclear membrane and the contiguous peripheral ER, the inner nuclear membrane (INM) house
Autor:
Conor McClenaghan, Colin G. Nichols
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Kir6.1 and SUR2 are subunits of ATP-sensitive potassium (KATP) channels expressed in a wide range of tissues. Extensive study has implicated roles of these channel subunits in diverse physiological functions. Together they generate the predominant KA