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Publikováno v:
American journal of physiology. Cell physiology. 323(6)
Stretch activation is defined as a delayed increase in force after rapid stretches. Although there is considerable evidence for stretch activation in isolated cardiac myofibrillar preparations, few studies have measured mechanisms of stretch activati
Publikováno v:
American journal of physiology. Cell physiology. 323(5)
Normal developmental processes, such as those seen during embryonic development and postpartum mammary gland involution, can be reactivated by cancer cells to promote immune suppression, tumor growth, and metastatic spread. In mammalian embryos, pate
Autor:
Matthew D. McGraw, Min Yee, So-Young Kim, Andrew M. Dylag, B. Paige Lawrence, Michael A. O’Reilly
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(5)
Bronchiolitis obliterans (BO) is a debilitating disease of the small airways that can develop following exposure to toxic chemicals as well as respiratory tract infections. BO development is strongly associated with diacetyl (DA) inhalation exposures
Autor:
Conor McClenaghan, Colin G. Nichols
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Kir6.1 and SUR2 are subunits of ATP-sensitive potassium (KATP) channels expressed in a wide range of tissues. Extensive study has implicated roles of these channel subunits in diverse physiological functions. Together they generate the predominant KA
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Inwardly rectifying potassium (Kir) channels are broadly expressed in many mammalian organ systems, where they contribute to critical physiological functions. However, the importance and function of the Kir5.1 channel (encoded by the KCNJ16 gene) hav
Autor:
Sara S. Procknow, Beth A. Kozel
Publikováno v:
American journal of physiology. Cell physiology. 323(3)
Elastin provides recoil to tissues that stretch such as the lung, blood vessels, and skin. It is deposited in a brief window starting in the prenatal period and extending to adolescence in vertebrates, and then slowly turns over. Elastin insufficienc
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(3)
The translational value of high-throughput toxicity testing will depend on pharmacokinetic validation. Yet, popular in vitro airway epithelia models were optimized for structure and mucociliary function without considering the bioactivation or detoxi
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 323(2)
Though survival rates for preterm infants are improving, the incidence of chronic lung disease of infancy, or bronchopulmonary dysplasia (BPD), remains high. Histologically, BPD is characterized by larger and fewer alveoli. Hypoxia-inducible factors
Publikováno v:
American journal of physiology. Cell physiology. 323(2)
Sickle cell disease (SCD) is an autosomal recessive genetic disorder that affects ∼100,000 Americans and millions of people worldwide. Erythrocyte sickling, vaso-occlusion, sterile inflammation, and hemolysis are the major pathophysiological pathwa
Autor:
Alasdair Cameron, Griffen Wakelin, Nicholas Gaulton, Laura V. Young, Scott Wotherspoon, Nathan Hodson, Matthew J. Lees, Daniel R. Moore, Adam P. Johnston
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C1586-C1600
Skeletal muscle repair and maintenance are directly and indirectly supported by interstitial cell populations such as vascular cells and fibro-adipogenic progenitors (FAPs), a subset of which express Twist2 and possess direct myogenic potential. Furt