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Autor:
Yoshiyuki Matsuo
Publikováno v:
Antioxidants & Redox Signaling. 36:984-1000
SIGNIFICANCE The presence of a large number of thioredoxin superfamily members suggests a complex mechanism of redox-based regulation in mammalian cells. However, whether these members are functionally redundant or play separate and distinct roles in
Autor:
Jiyuan Chen, Marisela Rodriguez, Jinrui Miao, Jing Liao, Pritesh P. Jain, Manjia Zhao, Tengteng Zhao, Aleksandra Babicheva, Ziyi Wang, Sophia Parmisano, Ryan Powers, Moreen Matti, Cole Paquin, Zahra Soroureddin, John Y.-J. Shyy, Patricia A. Thistlethwaite, Ayako Makino, Jian Wang, Jason X.-J. Yuan
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Concentric pulmonary vascular wall thickening due partially to increased pulmonary artery (PA) smooth muscle cell (PASMC) proliferation contributes to elevating pulmonary vascular resistance (PVR) in patients with pulmonary hypertension (PH). Althoug
Publikováno v:
Antioxidants & Redox Signaling. 36:1023-1036
Significance: Thioredoxin 1(Trx1) is a ubiquitous protein that is found in organisms ranging from prokaryotes to eukaryotes. Trx1 acts as reductases in redox regulation, protects proteins from oxid...
Publikováno v:
American Journal of Physiology-Cell Physiology. 322:C849-C864
Glycosaminoglycans (GAGs) are long, linear polysaccharides that are ubiquitously expressed on the cell surface and in the extracellular matrix of all animal cells. These complex carbohydrates play important roles in many cellular processes and have b
Publikováno v:
Journal of Bioenergetics and Biomembranes. 54:163-174
The aberrant downregulation of circCDC6 in colorectal cancer (CRC) was previously identified by circRNA microarray analysis. However, the detailed role of circCDC6 in CRC is still lacking. We thus investigated the function of circCDC6 in CRC. The exp
Autor:
Val J. Watts, Tarsis F. Brust, Roland Seifert, Justin E. LaVigne, Katrina F. Ostrom, Carmen W. Dessauer, Rennolds S. Ostrom
Publikováno v:
Physiol Rev
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9, that serve as major effector enzymes of G protein-coupled receptors (GPCRs). The trans
Autor:
Akihiko Taniguchi, Naohiro Oda, Daisuke Morichika, Satoru Senoo, Junko Itano, Utako Fujii, Lili Guo, Ryota Sunami, Katsuyuki Kiura, Yoshinobu Maeda, Nobuaki Miyahara
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 322:L539-L549
Neuropeptide Y (NPY) is a neuropeptide widely expressed in not only the central nervous system but also immune cells and the respiratory epithelium. Patients with chronic obstructive pulmonary disease (COPD) reportedly exhibit decreased NPY expressio
Autor:
Hans Ackerman, Mitchell J. Weiss, Miriam M. Cortese-Krott, Steven E. Brooks, Linda Columbus, T C Steven Keller, Christophe Lechauve, Brant E. Isakson, Alexander S. Keller
Publikováno v:
Physiol Rev
Globin proteins exist in every cell type of the vasculature, from erythrocytes to endothelial cells, vascular smooth muscle cells, and peripheral nerve cells. Many globin subtypes are also expressed in muscle tissues (including cardiac and skeletal m
Autor:
Fu Jun Li, Ranu Surolia, Pooja Singh, Kevin G. Dsouza, Crystal T. Stephens, Zheng Wang, Rui-Ming Liu, Sejong Bae, Young-Il Kim, Mohammad Athar, Mark T. Dransfield, Veena B. Antony
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
The etiologies of chronic obstructive pulmonary disease (COPD) remain unclear. Cadmium (Cd) causes both pulmonary fibrosis and emphysema; however, the predictors for Cd exposure and the mechanisms by which Cd causes COPD remain unknown. We demonstrat
Publikováno v:
Journal of Molecular Histology. 53:493-502
Echinacoside is a group of natural compounds extracted from medicinal plants Cistanche and Echinacea, which has neuroprotective, antiaging, immunomodulatory and anticancer effects, but its specific role and mechanism in tumor remains partially unclea