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Autor:
Uraiwan Panich, Malinee Saelim, Weerawon Thangboonjit, Anyamanee Chaiprasongsuk, Matthew Whiteman, Roberta Torregrossa, Saowanee Jeayeng, Jinapath Lohakul, Mark E. Wood
Publikováno v:
Antioxidants & Redox Signaling. 36:1268-1288
Aims: Oxidative stress and mitochondrial dysfunction play a role in the process of skin photoaging via activation of matrix metalloproteases (MMPs) and the subsequent degradation of collagen. The a...
Publikováno v:
Blood. 139:2130-2144
Modulation of neutrophil recruitment and function is crucial for targeting inflammatory cells to sites of infection to combat invading pathogens while, at the same time, limiting host tissue injury or autoimmunity. The underlying mechanisms regulatin
Autor:
Alistair M. Chalk, Monique Smeets, Iva Nikolic, Jane Jialu Xu, Carl R. Walkley, Kaylene J. Simpson
Publikováno v:
Blood Advances. 6:2092-2106
Current strategies to target RNA splicing mutant myeloid cancers proposes targeting the remaining splicing apparatus. This approach has only been modestly sensitizing and is also toxic to non-mutant-bearing wild-type cells. To explore potentially exp
Autor:
Linglei Jiang, Tom A.P. Driedonks, Wouter S.P. Jong, Santosh Dhakal, H. Bart van den Berg van Saparoea, Ioannis Sitaras, Ruifeng Zhou, Christopher Caputo, Kirsten Littlefield, Maggie Lowman, Mengfei Chen, Gabriela Lima, Olesia Gololobova, Barbara Smith, Vasiliki Mahairaki, M. Riley Richardson, Kathleen R. Mulka, Andrew P. Lane, Sabra L. Klein, Andrew Pekosz, Cory F. Brayton, Joseph L. Mankowski, Joen Luirink, Jason S. Villano, Kenneth W. Witwer
Publikováno v:
Jiang, L, Driedonks, T A P, Jong, W S P, Dhakal, S, Bart van den Berg van Saparoea, H, Sitaras, I, Zhou, R, Caputo, C, Littlefield, K, Lowman, M, Chen, M, Lima, G, Gololobova, O, Smith, B, Mahairaki, V, Riley Richardson, M, Mulka, K R, Lane, A P, Klein, S L, Pekosz, A, Brayton, C, Mankowski, J L, Luirink, J, Villano, J S & Witwer, K W 2022, ' A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type and Delta variants ', Journal of Extracellular Vesicles, vol. 11, no. 3, e12192, pp. 1-16 . https://doi.org/10.1002/jev2.12192
Journal of Extracellular Vesicles, 11(3):e12192, 1-16. Taylor & Francis
Journal of Extracellular Vesicles, 11(3):e12192, 1-16. Taylor & Francis
Several vaccines have been introduced to combat the coronavirus infectious disease-2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Current SARS-CoV-2 vaccines include mRNA-containing lipid nanoparticl
Publikováno v:
Antioxid Redox Signal
SIGNIFICANCE: Metformin has been proposed as a treatment for systemic lupus erythematosus (SLE). The primary target of metformin, the electron transport chain complex I in the mitochondria, is associated with redox homeostasis in immune cells, which
Autor:
Christopher A. Hunter, David A. Christian, Zachary A Hutchins, Masahiro Yamamoto, Julie B. Engiles, Daniel P. Beiting, Alexis R. Gibson, Gregory A. Taylor, Jodi A. Gullicksrud, Sebastian Shaw, Lindsay Martin, Boris Striepen, Adam Sateriale
Publikováno v:
Mucosal Immunology. 15:362-372
The intestinal parasite, Cryptosporidium, is a major contributor to global child mortality and causes opportunistic infection in immune deficient individuals. Innate resistance to Cryptosporidium, which specifically invades enterocytes, is dependent
Autor:
Abhinav Dey, Bing Yu, Kishore Kumar Jella, Anshu Malhotra, Jingbo Liu, Liangping Yuan, Tobey J. MacDonald, Matthew Schniederjan, Hongying Zhang, Leon F. McSwain
Publikováno v:
Molecular Oncology, Vol 16, Iss 4, Pp 1009-1025 (2022)
Sonic hedgehog (Shh)-driven medulloblastoma (Shh MB) cells are dependent on constitutive Shh signaling, but targeted treatment of Shh MB has been ineffective due to drug resistance. The purpose of this study was to address the critical role of signal
Autor:
Nataša Ristić, Jasmina Sretenovic, Kristina Andric, Jovan Rudic, Maja Nikolic, Jovana Joksimovic Jovic, Verica Milošević, Nikola Jovic, Biljana Milicic, Tijana Dimkic Tomic, Vladimir Zivkovic, Vladimir Jakovljevic
Publikováno v:
Reproduction. 163:11-21
Numerous evidence implies complex interrelations between polycystic ovary syndrome (PCOS) and hypertension (HT) in reproductive-age women. In this study, we aimed to investigate the potential strain differences in ovarian morphology, hemodynamic, and
Autor:
Mingqian Huang, Fang Wang, Zheng-Yi Chen, Yilai Shu, Yuanyuan Xue, Geng Lin Li, Zhijiao Xu, Di Li, Daqi Wang, Renjie Chai, Jun Shen, Jinan Zhou, Xi Gu, Erwei Zuo, Jinghan Wang, Hui Yang, Yige Li, Xinde Hu, Huawei Li
Publikováno v:
Mol Ther
Myosin VI(MYO6) is an unconventional myosin that is vital for auditory and vestibular function. Pathogenic variants in the human MYO6 gene cause autosomal-dominant or -recessive forms of hearing loss. Effective treatments for Myo6 mutation causin
Publikováno v:
Am J Physiol Cell Physiol
Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cellular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by complexes I