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Autor:
Christopher A. Hunter, David A. Christian, Zachary A Hutchins, Masahiro Yamamoto, Julie B. Engiles, Daniel P. Beiting, Alexis R. Gibson, Gregory A. Taylor, Jodi A. Gullicksrud, Sebastian Shaw, Lindsay Martin, Boris Striepen, Adam Sateriale
Publikováno v:
Mucosal Immunology. 15:362-372
The intestinal parasite, Cryptosporidium, is a major contributor to global child mortality and causes opportunistic infection in immune deficient individuals. Innate resistance to Cryptosporidium, which specifically invades enterocytes, is dependent
Autor:
Ilknur Bugan, Seyhan Altun, Pınar Koroglu Aydın, Omur Karabulut-Bulan, Refiye Yanardag, Ismet Burcu Turkyilmaz
Publikováno v:
Cell Biochemistry and Function. 40:60-70
Individuals with diabetes have an increased risk of breast, colorectal, pancreatic and prostate cancer. Metformin, an oral biguanide used to treat diabetes, has anti-hyperglycaemic, anti-hyperinsulinemic and antioxidant activities. The effects of met
Publikováno v:
Reproductive Sciences
The COVID-19 pandemic has been continuing for one and a half year and caused a profound effect on human health. Although advanced researches and literatures are gathered, the influences of SARS-CoV-2 on the reproduction systems are largely unknown, e
Autor:
Judith Hellman, Jérémie Joffre
Publikováno v:
Antioxidants & Redox Signaling. 35:1291-1307
Significance: Under homeostatic conditions, the endothelium dynamically regulates vascular barrier function, coagulation pathways, leukocyte adhesion, and vasomotor tone. During sepsis and acute inflammation, endothelial cells (ECs) undergo multiple
Publikováno v:
Inflammation. 45:992-1006
Hyperglycemia-induced oxidative stress in podocytes exerts a major role in the pathological process of diabetic nephropathy. Tripartite motif-containing protein 32 (TRIM32) has been reported to be a key protein in the modulation of cellular apoptosis
Publikováno v:
Journal of Cellular and Molecular Medicine
Reticulocalbin1 (RCN1) is implicated in tumorigenesis and tumour progression. However, whether RCN1‐mediated bone metastasis of non‐small cell lung cancer (NSCLC) cells was elusive. Here, we assessed the effect of osteoblast‐conditioned medium
Autor:
Rossella Ribolla, Joana Hauser, Marco Presta, Chiara Cattaneo, Roberto Ronca, Cosetta Ravelli, Arianna Giacomini, Federica Maccarinelli, Aldo M. Roccaro, Anna Staniszewska, Stefania Mitola, Alexey S. Revenko, Michele Moschetta, Philip Martin, Antonio Sacco, Niccolo Bolli, Bachisio Ziccheddu, Angelo Belotti, Giada Bianchi, Alessandra Tucci, Cinzia Federico, Helen Ambrose, Hongbo Cai, Robert A. Macleod, Lyndsey Hanson, Valentina Palermo, Giuseppe Rossi, Brandon Willis, Sarah Ross, Claire Rooney, Katia Todoerti, Vanessa Favasuli, Antonino Neri, Sophie E. Willis
Publikováno v:
Blood
Alterations in KRAS have been identified as the most recurring somatic variants in the multiple myeloma (MM) mutational landscape. Combining DNA and RNA sequencing, we studied 756 patients and observed KRAS as the most frequently mutated gene in pati
Publikováno v:
Biochemical and Biophysical Research Communications. 580:7-13
Angiogenesis, the formation of new blood vessels from the pre-existing ones, is a hallmark characteristic of glioblastoma, making it an appealing target for treatment development. Given potent anti-cancer efficacy of mefloquine, FDA-approved anti-mal
Autor:
Chengwei Tang, Yang Tai, Rui Liu, Shihang Tang, Huan Tong, Chong Zhao, Xintong Jia, Linhao Zhang, Jinhang Gao
Publikováno v:
Journal of Cellular and Molecular Medicine
The balance between endothelial nitric oxide (NO) synthase (eNOS) activation and production of reactive oxygen species (ROS) is very important for NO homeostasis in liver sinusoidal endothelial cells (LSECs). Overexpression of cyclooxygenase‐2 (COX
Autor:
Stefan Bittner, Alexander M. Herrmann, Frauke Zipp, Sarah Lauks, Sven G. Meuth, Lisanne Korn, Martin Diebold, Felix Luessi, Simone König, Marie Liebmann, Andreas Schulte-Mecklenbeck, Claudia Janoschka, Nicholas Schwab, Heinz Wiendl, Stephan Schmidt, Stjepana Kovac, Tilman Schneider-Hohendorf, Stefanie Albrecht, Catharina C. Gross, Maria Eveslage, Tanja Kuhlmann, Tobias Derfuss, Luisa Klotz, Brigitte Wildemann
Publikováno v:
Brain. 144:3126-3141
Dimethyl fumarate, an approved treatment for relapsing-remitting multiple sclerosis, exerts pleiotropic effects on immune cells as well as CNS resident cells. Here, we show that dimethyl fumarate exerts a profound alteration of the metabolic profile