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Publikováno v:
Nat Metab
Innate lymphoid cells (ILCs) are a family of predominantly tissue-resident lymphocytes that critically orchestrate immunity, inflammation, tolerance, and repair at barrier surfaces of the mammalian body. Heterogeneity among ILC subsets is comparable
Autor:
Shanshan Qiao, Chang Liu, Li Sun, Tao Wang, Huanqin Dai, Kai Wang, Li Bao, Hantian Li, Wenzhao Wang, Shuang-Jiang Liu, Hongwei Liu
Publikováno v:
Nature Metabolism. 4:1271-1286
Obesity, dyslipidemia and gut dysbiosis are all linked to cardiovascular diseases. A Ganoderma meroterpene derivative (GMD) has been shown to alleviate obesity and hyperlipidemia through modulating the gut microbiota in obese mice. Here we show that
Autor:
Evgeniy Panzhinskiy, Haoning Cen, Timothy J. Kieffer, Mark O. Huising, Søs Skovsø, James D. Johnson, Xiaoke Hu, Honey Modi, Derek A. Dionne, Yiwei Bernie Zhao, Shouhong Xuan, Nicole A.J. Krentz, Nilou Noursadeghi, Cara E. Ellis, Francis C. Lynn, Yi Han Xia, Chieh Min Jamie Chu
Publikováno v:
Diabetes. 71:2612-2631
Heterogeneity within specific cell types is common and increasingly apparent with the advent of single cell transcriptomics. Transcriptional and functional cellular specialization has been described for insulin-secreting β cells of the endocrine pan
Autor:
Veronica Pena-Leon, Cintia Folgueira, Silvia Barja-Fernández, Raquel Pérez-Lois, Natália Da Silva Lima, Marion Martin, Violeta Heras, Sara Martinez-Martinez, Paola Valero, Cristina Iglesias, Mannon Duquenne, Omar Al-Massadi, Daniel Beiroa, Yara Souto, Miguel Fidalgo, Rasika Sowmyalakshmi, Diana Guallar, Juan Cunarro, Cecilia Castelao, Ana Senra, Patricia González-Saenz, Rocío Vázquez-Cobela, Rosaura Leis, Guadalupe Sabio, Helge Mueller-Fielitz, Markus Schwaninger, Miguel López, Sulay Tovar, Felipe F. Casanueva, Emmanuel Valjent, Carlos Diéguez, Vincent Prevot, Rubén Nogueiras, Luisa M. Seoane
Publikováno v:
Nature Metabolism
Nature Metabolism, 2022, 4 (7), pp.901-917. ⟨10.1038/s42255-022-00602-z⟩
Nature Metabolism, 2022, 4 (7), pp.901-917. ⟨10.1038/s42255-022-00602-z⟩
Early-life determinants are thought to be a major factor in the rapid increase of obesity. However, while maternal nutrition has been extensively studied, the effects of breastfeeding by the infant on the reprogramming of energy balance in childhood
Autor:
Heiko Endle, Guilherme Horta, Bernardo Stutz, Muthuraman Muthuraman, Irmgard Tegeder, Yannick Schreiber, Isabel Faria Snodgrass, Robert Gurke, Zhong-Wu Liu, Matija Sestan-Pesa, Konstantin Radyushkin, Nora Streu, Wei Fan, Jan Baumgart, Yan Li, Florian Kloss, Sergiu Groppa, Nils Opel, Udo Dannlowski, Hans J. Grabe, Frauke Zipp, Bence Rácz, Tamas L. Horvath, Robert Nitsch, Johannes Vogt
Publikováno v:
Nat Metab
Phospholipid levels are influenced by peripheral metabolism. Within the central nervous system, synaptic phospholipids regulate glutamatergic transmission and cortical excitability. Whether changes in peripheral metabolism affect brain lipid levels a
Autor:
Qi Liu, Fangming Zhu, Xinnan Liu, Ying Lu, Ke Yao, Na Tian, Lingfeng Tong, David A. Figge, Xiuwen Wang, Yichao Han, Yakui Li, Yemin Zhu, Lei Hu, Yingning Ji, Nannan Xu, Dan Li, Xiaochuan Gu, Rui Liang, Guifang Gan, Lifang Wu, Ping Zhang, Tianle Xu, Hui Hu, Zeping Hu, Huji Xu, Dan Ye, Hui Yang, Bin Li, Xuemei Tong
Publikováno v:
Nature Metabolism. 4:559-574
Regulatory T (T
Autor:
Suelen Martins Perobelli, Chi L. Nguyen, Anastasia I. Kousa, Jonathan U. Peled, Joseph C. Sun, Justin R. Cross, Eli Zamir, Robert R. Jenq, Sebastien Monette, Melody Smith, Melissa D. Docampo, Ann E. Slingerland, Christoph K. Stein-Thoeringer, Clair D. Geary, Itamar Greenfield, Marina Burgos da Silva, Sophia R. Lieberman, Nicole Lee, Yusuke Shono, Gabe K Armijo, Emmanuel A Dwomoh, Kate A Markey, Marcel R M Rm van den Brink, Amina Lazrak, Katherine B Nichols, Santosha Vardhana
Publikováno v:
Blood
The intestinal microbiota is essential for the fermentation of dietary fiber into short-chain fatty acids (SCFA) such as butyrate, acetate, and propionate. SCFAs can bind to the G-protein-coupled receptors GPR43 and GPR109A (HCAR2), with varying affi
Autor:
Lingming Chen, Guoliang Zhang, Guobao Li, Wei Wang, Zhenhuang Ge, Yi Yang, Xing He, Zhi Liu, Zhiyi Zhang, Qiongdan Mai, Yiwei Chen, Zixu Chen, Jiang Pi, Shuai Yang, Jun Cui, Haipeng Liu, Ling Shen, Lingchan Zeng, Lin Zhou, Xinchun Chen, Baoxue Ge, Zheng W. Chen, Gucheng Zeng
Publikováno v:
Nature Metabolism. 4:359-373
Both host genetics and the gut microbiome have important effects on human health, yet how host genetics regulates gut bacteria and further determines disease susceptibility remains unclear. Here, we find that the gut microbiome pattern of participant
Autor:
Noopur Raje, Chukwuamaka Onyewadume, Cristina Panaroni, Ka Tat Siu, Keertik Fulzele, Tomoaki Mori, Allison Maebius
Publikováno v:
Blood
Adipocytes occupy 70% of the cellular volume within the bone marrow (BM) wherein multiple myeloma (MM) originates and resides. However, the nature of the interaction between MM cells and adipocytes remains unclear. Cancer-associated adipocytes suppor
Autor:
Michitada Hirano, Yusei So, Shin Tsunekawa, Mio Kabata, Sho Ohta, Hiroshi Sagara, Nao Sankoda, Jumpei Taguchi, Yosuke Yamada, Tomoyo Ukai, Makoto Kato, Jiro Nakamura, Manabu Ozawa, Takuya Yamamoto, Yasuhiro Yamada
Publikováno v:
Nature Metabolism. 4:254-268
β cells have a limited capacity for regeneration, which predisposes towards diabetes. Here, we show that, of the MYC family members, Mycl plays a key role in proliferation of pancreatic endocrine cells. Genetic ablation of Mycl causes a reduction in