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Autor:
Devika P. Bagchi, Ormond A. MacDougald
Publikováno v:
Diabetes
Wnt signaling is an ancient and evolutionarily conserved pathway with fundamental roles in the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate determination and differentiation have been extensively studied. Indeed
Autor:
Lale Bakir, Ayman Al-Hendy, Prosper Igboeli, Amro Elsharoud, Hang-Soo Park, Jan M. McAllister, Sahar Esfandyari, Abdeljabar El Andaloussi, Rishi Man Chugh, Nahed Ismail, Mara Ulin, Mohamed Ali, Dalia Ashour, Alshimaa Aboalsoud
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-19 (2021)
Stem Cell Research & Therapy
Stem Cell Research & Therapy
Background Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in reproductive-age women. Excessive inflammation and elevated androgen production from ovarian theca cells are key features of PCOS. Human bone marrow me
Publikováno v:
Experimental hematology
The clinical success of engineered, CD19-directed chimeric antigen receptor (CAR) T cells in relapsed, refractory B-cell acute lymphoblastic leukemia (B-ALL) has generated great enthusiasm for the use of CAR T cells in patients with cytogenetics that
Publikováno v:
Journal of Cellular and Molecular Medicine
Chemokine C‐C motif ligand 7 (CCL7), a member of CC chemokine subfamily, plays pivotal roles in numerous inflammatory diseases. Hyper‐activation of inflammation is an important characteristic of abdominal aortic aneurysm (AAA). Therefore, in the
Publikováno v:
Molecular and Cellular Biochemistry
Graphical abstract Human SARS Coronavirus-2 (SARS-CoV-2) has infected more than 170 million people worldwide and resulted in more than 3.5 million deaths so far. The infection causes Coronavirus disease (COVID-19) in people of all age groups, notably
Publikováno v:
Clinical and Experimental Nephrology. 25:1182-1192
Tubular injury plays a crucial role in the pathogenesis of diabetic nephropathy (DN). It is well known that many microRNAs (miRNAs) exert crucial effects on tubular injury. This study intends to explore the effect of miR-142-3p on the apoptosis and o
Publikováno v:
Journal of Cellular and Molecular Medicine
Metabolism of progesterone (P4) by the enzyme 20α hydroxysteroid dehydrogenase (20α‐HSD) in myometrial cells is postulated to be a mechanism for P4 withdrawal, which occurs concomitant to uterine inflammation (physiologic or infection‐induced)
Autor:
Arisa Ochi, Yasumasa Ikeda, Naoki Kashihara, Kojiro Nagai, Kensei Taguchi, Masanori Tamaki, Ken-ichi Aihara, Hideharu Abe, Masashi Miyoshi, Craig R. Brooks, Hiroyuki Kadoya, Kenji Nishimura, Seiji Kishi
Publikováno v:
Biochemical and Biophysical Research Communications. 556:142-148
The relationship between cellular senescence and fibrosis in the kidney is being elucidated and we have identified it as therapeutic target in recent studies. Chronic kidney disease has also become a lifestyle disease, often developing on the backgro
Autor:
Joshua W. Goyert, Ho-Joon Lee, Sumeet Solanki, Matthew G. Vander Heiden, Samuel A. Kerk, Brian T. Do, Costas A. Lyssiotis, Yatrik M. Shah, Brandon Chen, Jason R. Spence, Michael K. Dame, Cristina Castillo, Xiang Xue, Peggy P. Hsu, Andrew J. Schwartz, Samira Lakhal-Littleton, Rashi Singhal
Publikováno v:
Nature metabolism
Colorectal cancer (CRC) requires massive iron stores, but the complete mechanisms by which CRC modulates local iron handling and metabolically leverages iron are poorly understood. We demonstrate that the liver-derived, endocrine regulator of systemi
Autor:
Sijia Wang, Xiaoyu Han, Yanjie Guo, Qiongqiong Jia, Boqun Liu, Yingpu Sun, Yang Yan, Lanlan Fang, Jung-Chien Cheng, Yiran Li
Publikováno v:
International Journal of Biological Sciences
Rationale: Growth differentiation factor-8 (GDF-8), also known as myostatin, belongs to the transforming growth factor-beta (TGF-β) superfamily. GDF-8 is expressed in the ovary and regulates various ovarian functions. Ovarian hyperstimulation syndro