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Autor:
Hyo In Kim, Elzbieta Kaczmarek, Ingred Riça, Jinbong Park, Barbora Konečná, Kiyoshi Itagaki, Carl J. Hauser
Publikováno v:
Antioxid Redox Signal
Significance: Sepsis is a major public health concern, with high mortality and morbidity, especially among patients undergoing trauma. It is characterized by a systemic inflammatory response syndrome (SIRS) occurring in response to infection. Althoug
Autor:
Judith Hellman, Jérémie Joffre
Publikováno v:
Antioxidants & Redox Signaling. 35:1291-1307
Significance: Under homeostatic conditions, the endothelium dynamically regulates vascular barrier function, coagulation pathways, leukocyte adhesion, and vasomotor tone. During sepsis and acute inflammation, endothelial cells (ECs) undergo multiple
Publikováno v:
Antioxid Redox Signal
Significance: Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection. This leads to an uncontrolled inflammatory response at the onset of infection, followed by immunosuppression. The development o
Autor:
Rachel Warren, Gloria S. Pryhuber, Andrew M. Dylag, Jeannie Haak, Min Yee, Michael A. O'Reilly
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
It is well known that supplemental oxygen used to treat preterm infants in respiratory distress is associated with permanently disrupting lung development and the host response to influenza A virus (IAV). However, many infants who go home with normal
Autor:
Pei Xiong Liew
Publikováno v:
Am J Physiol Cell Physiol
Inflammation of the kidney is a key contributor to proliferative glomerulonephritis, and kidney damage during glomerulonephritis can lead to renal failure. The immune response associated with glomerulonephritis episodes is a major determinant of pati
Autor:
Scott J. Denstaedt, Benjamin H. Singer, Bethany B. Moore, A.C. Bustamante, Rachel L. Zemans, Theodore J. Standiford, Michael W. Newstead
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Millions of people who survive sepsis each year are rehospitalized and die due to late pulmonary complications. To prevent and treat these complications, biomarkers and molecular mediators must be identified. Persistent immune reprogramming in the fo
Autor:
Gary D. Marty, Kyle A. Garver, Anthony P. Farrell, Mark P. Polinski, Colin J. Brauner, Phillip R. Morrison, Yangfan Zhang
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-15 (2021)
BMC Biology
BMC Biology
Background Viruses can impose energetic demands on organisms they infect, in part by hosts mounting resistance. Recognizing that oxygen uptake reliably indicates steady-state energy consumption in all vertebrates, we comprehensively evaluated oxygen
Autor:
Mukesh Samant, Utkarsha Sahu, Prashant Khare, Vijay Kumar Prajapati, Anirudh K. Singh, Debasis Biswas
Publikováno v:
Journal of Cellular Physiology
Viral infections are a major threat to the human population due to the lack of selective therapeutic measures. The morbidity and mortality reported worldwide are very alarming against viral pathogens. The proinflammatory environment is required for v
Autor:
Sabine Steffens, Sibgha Tahir
Publikováno v:
American Journal of Physiology-Cell Physiology. 320:C761-C770
Monocytes are a heterogeneous cell population of innate immune cells with distinct cell surface markers that help them in carrying out different functions. In humans, there are three well-characterized subsets, namely, classical (CD14++CD16−), inte
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 320:L165-L178
Inflammasomes are multiprotein complexes tasked with sensing endogenous or exogenous inflammatory signals and integrating this signal into a downstream response. Inflammasome activation has been implicated in a variety of pulmonary diseases, includin