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Autor:
Paul M. Daniel, Frédéric Hollande, Andrew P. Morokoff, Gulay Filiz, Sebastian Dworkin, Theo Mantamadiotis, Daniel Brown, Wayne Ng, Nicole Kountouri, Stephanie Amiridis
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)
PLoS ONE, Vol 12, Iss 2, p e0172791 (2017)
Glioblastoma (GBM) is a heterogeneous tumor of the brain with a poor prognosis due to recurrence and drug resistance following therapy. Genome-wide profiling has revealed the existence of distinct GBM molecular subtypes that respond differently to ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b93541fc9763c8c99c234f613764a359
Autor:
Yoko Kubuki, Kengo Takeuchi, Seishi Ogawa, Yuki Tahira, Akifumi Takaori-Kondo, Kota Yoshifuji, Makoto Yoshimitsu, Kenichi Chiba, Masaaki Sekine, Ai Okada, Ana Acuna-Villaorduna, Yuichi Shiraishi, Yasushi Miyazaki, Tatsuhiro Shibata, Jun-ichirou Yasunaga, Tomonori Hidaka, Michihiro Hidaka, Mariko Tabata, Kisato Nosaka, Masao Matsuoka, Yasunori Kogure, Takuro Kameda, R. Alejandro Sica, Yuta Ito, B. Hilda Ye, Yoshitaka Imaizumi, Ayako Kamiunten, Sumito Shingaki, Keiichi Akizuki, Yuki Saito, Juan Carlos Ramos, Kazuya Shimoda, Junji Koya, Murali Janakiram, Marni B McClure, Urvi A Shah, Yasuhito Nannya, Kenji Ishitsuka, Mizuki Watanabe, Nobuaki Nakano, Satoru Miyano, Nobuyuki Kakiuchi, Atae Utsunomiya, Keisuke Kataoka, Kotaro Shide, Akira Kitanaka
Publikováno v:
Blood. 139:967-982
Adult T-cell leukemia/lymphoma (ATL) is an aggressive neoplasm immunophenotypically resembling regulatory T cells, associated with human T-cell leukemia virus type-1. Here, we performed whole-genome sequencing (WGS) of 150 ATL cases to reveal the ove
Publikováno v:
IET Systems Biology, Vol 16, Iss 1, Pp 28-41 (2022)
Stroke is one of the leading causes of patients' death and long‐term disability worldwide, and ischaemic stroke (IS) accounts for nearly 80% of all strokes. Differential genes and weighted gene co‐expression network analysis (WGCNA) in male and f
Autor:
Jean-Paul Courneya, Rita Fishelevich, Irina G. Luzina, Violeta Rus, Sergei P. Atamas, Brian Hampton, Alexander V. Misharin, Nevins W. Todd, Virginia Lockatell, Tudor C. Badea, Horea Rus
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 66:146-157
Some previous studies in tissue fibrosis have suggested a profibrotic contribution from elevated expression of a protein termed either Regulator of Cell Cycle (RGCC) or Response Gene to Complement 32 Protein (RGC-32). Our analysis of public gene expr
Autor:
Stephen S. Rich, Donna Neuberg, Michael H. Cho, Bing Yu, Matthew Leventhal, George T. O'Connor, Ani Manichaikul, Weiwei Shi, Lynette M. Sholl, Michael C. Honigberg, Abhishek Niroula, Benjamin L. Ebert, Joselyn Rojas-Quintero, R. Graham Barr, Matthew Moll, Stephanie J. London, L. Adrienne Cupples, Siddhartha Jaiswal, Elizabeth C. Oelsner, Brittany E Sandoval, Pradeep Natarajan, Brian E. Cade, Peter van Galen, Susan Redline, Yohannes Tesfaigzi, Christopher J. Gibson, Stephanie M. Gogarten, COPDGene Study Investigators, Deepti Jain, Adolfo Correa, Bruce D. Levy, Sina A. Gharib, Peter Miller, Kaushik Viswanathan, Caroline A. Owen, Edwin K. Silverman, Lillian Werner, Jerome I. Rotter, Dandi Qiao, Brian C. Miller, Adam S. Sperling, Leslie A. Lange, Alexander G. Bick, Marie McConkey, Vasan S. Ramachandran
Publikováno v:
Blood. 139:357-368
Chronic obstructive pulmonary disease (COPD) is associated with age and smoking, but other determinants of the disease are incompletely understood. Clonal hematopoiesis of indeterminate potential (CHIP) is a common, age-related state in which somatic
Autor:
Jie Zhang, Weilong Zhong, Simin Zhou, Xiaoyi Wang, Jingwen Zhao, Man Liu, Lu Zhang, Lu Zhou, Xin Liu, Bangmao Wang, Hongxia Zhang
Publikováno v:
International Journal of Biological Sciences
Autoimmune hepatitis (AIH) is an immune-mediated chronic inflammatory liver disease, and its pathogenesis is not fully understood. Our previous study discovered that receptor interacting protein kinase 3 (RIP3) is correlated with serum transaminase l
Autor:
Angeles Fernandez-Gonzalez, S. Alex Mitsialis, Lawrence S. Prince, Xianlan Liu, Vincent Yeung, Stella Kourembanas, Gareth R. Willis, Elizabeth S. Taglauer, Monica Reis
Publikováno v:
Am J Respir Cell Mol Biol
In preeclamptic pregnancies, a variety of intrauterine alterations lead to abnormal placentation, release of inflammatory and/or antiangiogenic factors, and subsequent fetal growth restriction with significant potential to cause a primary insult to t
Publikováno v:
International Journal of Biological Sciences
The use of large molecules for immunotherapy has led to exciting developments in cancer treatment, such as the development of PD-1/PD-L1 antibodies. However, small molecule targeted therapies still lack effective immune-functional classes. Ideal anti
Autor:
Qingwei Meng, Yongxu Zhou, Jianxiong Geng, Bo Pan, Lishuang Qi, Yan Yu, Yingyue Cao, Zijie Wang, Xin Wang, Zixin Wei, Shi Jin, Yaoguo Lang, Shanqi Xu
Publikováno v:
International Journal of Biological Sciences
RNA-binding motif protein 10 (RBM10), one of the members of the RNA-binding protein (RBP) family, has a tumor suppressor role in multiple cancers. However, the functional role of RBM10 in lung adenocarcinoma (LUAD) and the underlying molecular mechan
Autor:
Qian-jin Liao, Zhao-Yi Liu, Xiaoye Zhang, Miaochen Zhu, Ying Wang, Lu Liu, Xue Chen, Yong-Chang Chen, Nayiyuan Wu, He Li, Jing Wang, Longzheng Xia
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-19 (2022)
Journal of Experimental & Clinical Cancer Research : CR
Journal of Experimental & Clinical Cancer Research : CR
Background Tumor cell metabolic reprogramming is crucial for the malignant behavior of cancer cells by promoting their proliferation. However, little is known on how transient receptor potential 7 (TRPM7) modulates metabolic reprogramming in ovarian