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Autor:
Uraiwan Panich, Malinee Saelim, Weerawon Thangboonjit, Anyamanee Chaiprasongsuk, Matthew Whiteman, Roberta Torregrossa, Saowanee Jeayeng, Jinapath Lohakul, Mark E. Wood
Publikováno v:
Antioxidants & Redox Signaling. 36:1268-1288
Aims: Oxidative stress and mitochondrial dysfunction play a role in the process of skin photoaging via activation of matrix metalloproteases (MMPs) and the subsequent degradation of collagen. The a...
Autor:
Joanne F Garbincius, John W. Elrod
Publikováno v:
Physiol Rev
The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a fundamental biological process that has critical effects on cellular metabolism, signaling, and survival. Disruption of mitochondrial calcium (mCa2+) cycling is im
Publikováno v:
Antioxidants & Redox Signaling. 36:1023-1036
Significance: Thioredoxin 1(Trx1) is a ubiquitous protein that is found in organisms ranging from prokaryotes to eukaryotes. Trx1 acts as reductases in redox regulation, protects proteins from oxid...
Autor:
Val J. Watts, Tarsis F. Brust, Roland Seifert, Justin E. LaVigne, Katrina F. Ostrom, Carmen W. Dessauer, Rennolds S. Ostrom
Publikováno v:
Physiol Rev
Adenylyl cyclases (ACs) catalyze the conversion of ATP to the ubiquitous second messenger cAMP. Mammals possess nine isoforms of transmembrane ACs, dubbed AC1–9, that serve as major effector enzymes of G protein-coupled receptors (GPCRs). The trans
Publikováno v:
Annual Review of Physiology. 84:355-379
Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the endoplasmic reticulum (ER) Ca2+ stores are emptied through activation of inositol-1
Autor:
Antonio Cruz, Nuria Roldan, José Carlos Castillo-Sánchez, Emma Batllori, Alberto Galindo, Begoña Garcia-Alvarez, Jesús Pérez-Gil
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 322:L191-L203
By coating the alveolar air-liquid interface, lung surfactant overwhelms surface tension forces that, otherwise, would hinder the lifetime effort of breathing. Years of research have provided a picture of how highly hydrophobic and specialized protei
Autor:
William E. Louch, Geir Christensen, Pimthanya Wanichawan, Hilde Jarstadmarken, Enno Klussmann, Marie C. Moutty, Ivar Sjaastad, Viacheslav O. Nikolaev, Cathrine R. Carlson, Per Kristian Lunde, Laetitia Pereira, Anna Bergan-Dahl, Ole M. Sejersted, Jan Magnus Aronsen, Marianne Lunde, Terje R Selnes Kolstad, Susanne Hille, Donald M. Bers, Bjørn Dalhus, Hariharan Subramanian, Oliver Müller, Xin Shen
Publikováno v:
Circulation research, vol 130, iss 1
Background: The sarcoplasmic reticulum (SR) Ca 2+ -ATPase 2 (SERCA2) mediates Ca 2+ reuptake into SR and thereby promotes cardiomyocyte relaxation, whereas the ryanodine receptor (RYR) mediates Ca 2+ release from SR and triggers contraction. Ca 2+ /C
Autor:
Danforth A. Newton, Rita M. Ryan, Manjeet K. Paintlia, Demetri D. Spyropoulos, Alan H. Jobe, Matthew W. Kemp, John E. Baatz
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Atrial natriuretic peptide (ANP) and its receptors natriuretic peptide receptor (NPR)-A and NPR-C are all highly expressed in alveolar epithelial type II cells (AEC2s) in the late-gestation ovine fetal lung and are dramatically decreased postnatally.
Publikováno v:
Am J Physiol Cell Physiol
Mitochondrial reactive oxygen species (ROS) have emerged as an important mechanism of disease and redox signaling in the cellular system. Under basal or pathological conditions, electron leakage for ROS production is primarily mediated by complexes I
Autor:
Keiji Yasukawa
Publikováno v:
Antioxidants & Redox Signaling. 36:160-171
Significance: Redox-based theranostics involves redox monitoring and therapeutics that normalize redox imbalance. It may be a promising approach to markedly improve a patient’s quality of life thro...