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Publikováno v:
American journal of physiology. Cell physiology. 323(6)
Stretch activation is defined as a delayed increase in force after rapid stretches. Although there is considerable evidence for stretch activation in isolated cardiac myofibrillar preparations, few studies have measured mechanisms of stretch activati
Publikováno v:
ACS Chemical Neuroscience. 13:2728-2742
Transient receptor potential canonical 5 (TRPC5) channels are predominantly expressed in the striatum and substantia nigra of the brain. These channels are permeable to calcium ions and are activated by oxidative stress. The physiological involvement
Autor:
Ana Cristina, Roginski, Ângela Beatris, Zemniaçak, Rafael Aguiar, Marschner, Simone Magagnin, Wajner, Rafael Teixeira, Ribeiro, Moacir, Wajner, Alexandre Umpierrez, Amaral
Publikováno v:
Journal of Bioenergetics and Biomembranes. 54:203-213
Propionic acid (PA) predominantly accumulates in tissues and biological fluids of patients affected by propionic acidemia that may manifest chronic renal failure along development. High urinary excretion of maleic acid (MA) has also been described. C
Autor:
Joanne F Garbincius, John W. Elrod
Publikováno v:
Physiol Rev
The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a fundamental biological process that has critical effects on cellular metabolism, signaling, and survival. Disruption of mitochondrial calcium (mCa2+) cycling is im
Publikováno v:
Annual Review of Physiology. 84:355-379
Store-operated Ca2+ entry (SOCE) is a ubiquitous Ca2+ signaling pathway that is evolutionarily conserved across eukaryotes. SOCE is triggered physiologically when the endoplasmic reticulum (ER) Ca2+ stores are emptied through activation of inositol-1
Autor:
Yongle Song, Longjiao Li, Xinyu Mo, Ming Pan, Bang Shen, Rui Fang, Min Hu, Junlong Zhao, Yanqin Zhou
Publikováno v:
Microbiology Spectrum. 10
Toxoplasma gondii (T. gondii) is a pathogen belonging to the apicomplexan phylum, and it threatens human and animal health. Calcium ions, a critical second messenger in cells, can regulate important biological processes, including parasite invasion a
Publikováno v:
Journal of Molecular Histology
Lipid metabolism is closely related to the improvement of vascular calcification (VC) in chronic kidney disease (CKD). Globular adiponectin (gAd) has been reported to be involved in the development of VC in CKD, but the detailed regulatory role remai
Autor:
Nam Young Kim, Minjeong Kwon, Ye Hee Kang, Hyeong Ju Song, Narae Kim, Woojin Jeong, Hyun Jin Kim, Dong Min Shin, Hye In Lee, Jin Ha Park, Gong Rak Lee, Jiae Lee, TaeSoo Kim
Publikováno v:
Journal of Cellular Physiology. 236:8239-8252
Many bone diseases such as osteoporosis and periodontitis are caused by hyperactivation of osteoclasts. Calcium (Ca2+ ) signals are crucial for osteoclast differentiation and function. Thus, the blockade of Ca2+ signaling may be a strategy for regula
Autor:
Friedrich Schöppler, Jens Broscheit, Reine-Solange Sauer, Adel Ben-Kraiem, Ivo Krummenacher, Helga Stopper, Norbert Roewer, Shaobing Yang, Holger Braunschweig, Ulrike Holzgrabe, Milad Mohammadi, Beatrice Oehler, Heike L. Rittner, Ezgi Eylül Bankoglu, Alexander Brack, Paul Güntzel
Publikováno v:
Antioxidants & Redox Signaling. 34:1260-1279
Aims: Delphinidin (DEL) is a plant-derived antioxidant with clinical potential to treat inflammatory pain but suffers from poor solubility and low bioavailability. The aim of the study was to devel...
Autor:
Amir Sagi, Simy Weil, Fuhua Li, Shihao Li, Rivka Manor, Eliahu D. Aflalo, Xuguang Li, Shmuel Bentov, Shai Abehsera, Isam Khalaila, Shahar Sagi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
During their life, crustaceans undergo several molts, which if theoretically compared to the human body would be equivalent to replacing all bones at a single event. Such a dramatic repetitive event is coupled to unique molecular mechanisms of minera