Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Jain R"'
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Metronomic dosing of chemotherapy - defined as frequent administration at lower doses - has been shown to be more efficacious than maximum tolerated dose treatment in preclinical studies, and is currently being tested in the clinic. Although multiple
Autor:
Stylianopoulos, T., Jain, R. K.
Publikováno v:
Nanomedicine: Nanotechnology, Biology, and Medicine
Nanotherapeutics have improved the quality of life of cancer patients, primarily by reducing the adverse effects of chemotherapeutic agents, but improvements in overall survival are modest. This is in large part due to the fact that the enhanced perm
Publikováno v:
Annual Review of Biomedical Engineering
Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, they can increase cells' inva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31342236a2aef544510573096a5bb0b9
http://gnosis.library.ucy.ac.cy/handle/7/48436
http://gnosis.library.ucy.ac.cy/handle/7/48436
Publikováno v:
Cancer research
In solid tumors, angiogenesis occurs in the setting of a defective vasculature and impaired lymphatic drainage that is associated with increased vascular permeability and enhanced tumor permeability. These universal aspects of the tumor microenvironm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24c6a59099939ffa8eb56488db65d06c
https://europepmc.org/articles/PMC3876035/
https://europepmc.org/articles/PMC3876035/
Autor:
Chauhan, V., Boucher, Y., Ferrone, C., Roberge, S., Martin, J., Stylianopoulos, T., Bardeesy, N., DePinho, R., Padera, T., Munn, L., Jain, R.
Publikováno v:
Cancer Cell
Impaired perfusion is a hallmark of solid tumors that promotes progression, immunosuppression and treatment-resistance, and is partly caused by vascular compression from excessive extravascular stresses (Chauhan et al., 2013; Stylianopoulos et al., 2
Publikováno v:
British Journal of Cancer
Scopus-Elsevier
CIÊNCIAVITAE
Scopus-Elsevier
CIÊNCIAVITAE
We have developed a new technique to measure in vivo tumour tissue fluid transport parameters (hydraulic conductivity and compliance) that influence the systemic and intratumoral delivery of therapeutic agents. An infusion needle approximating a poin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7810161f36ffa873522954ccf7db94e5
http://hdl.handle.net/11588/154998
http://hdl.handle.net/11588/154998